336,956 research outputs found

    GREY DEEP NEURAL NETWORK-BASED DATA ANALYSIS FOR FINANCIAL REPORTS IN TEXT MINING APPLICATIONS

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     The proposes the epic Gray Deep Neural Network Model (GDNNM), Multi-Layer Perception (MLP) Neural Network (NN) and computer integration, Model Identification Failure Prediction (MIFP) schemes. Data analysis for financial they can approximate both GDNNM and non-linear individual frame elements as a class. Based on the neural network model, unlike previous discrimination proof strategies, GDNNM subordinates frame elements to acquire an independent direct characteristic. This model has a good relationship with the project structure but is difficult to fit. The PGDM program is installed online financial data as a common sample criteria to get the remaining amount between the frame release and the GDNNM release. Early Diagnosis of Problem detection is important when building a structure, as it can save a considerable amount of space and time. With the progress of intelligent assembly, the lack of information-based search becomes an interesting issue. There are so many sources Text mining is a wide range of information testing used in semi-primary and non-basic information inquiries. This type of data is expected to cause problems in the financial information industry and problems in text mining for basic non-information testing. Besides, the checkpoints have been application research in the field of currency data, past research, auditing and control

    The science of clinical practice: disease diagnosis or patient prognosis? Evidence about "what is likely to happen" should shape clinical practice.

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    BACKGROUND: Diagnosis is the traditional basis for decision-making in clinical practice. Evidence is often lacking about future benefits and harms of these decisions for patients diagnosed with and without disease. We propose that a model of clinical practice focused on patient prognosis and predicting the likelihood of future outcomes may be more useful. DISCUSSION: Disease diagnosis can provide crucial information for clinical decisions that influence outcome in serious acute illness. However, the central role of diagnosis in clinical practice is challenged by evidence that it does not always benefit patients and that factors other than disease are important in determining patient outcome. The concept of disease as a dichotomous 'yes' or 'no' is challenged by the frequent use of diagnostic indicators with continuous distributions, such as blood sugar, which are better understood as contributing information about the probability of a patient's future outcome. Moreover, many illnesses, such as chronic fatigue, cannot usefully be labelled from a disease-diagnosis perspective. In such cases, a prognostic model provides an alternative framework for clinical practice that extends beyond disease and diagnosis and incorporates a wide range of information to predict future patient outcomes and to guide decisions to improve them. Such information embraces non-disease factors and genetic and other biomarkers which influence outcome. SUMMARY: Patient prognosis can provide the framework for modern clinical practice to integrate information from the expanding biological, social, and clinical database for more effective and efficient care

    Evaluation of the current knowledge limitations in breast cancer research: a gap analysis

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    BACKGROUND A gap analysis was conducted to determine which areas of breast cancer research, if targeted by researchers and funding bodies, could produce the greatest impact on patients. METHODS Fifty-six Breast Cancer Campaign grant holders and prominent UK breast cancer researchers participated in a gap analysis of current breast cancer research. Before, during and following the meeting, groups in seven key research areas participated in cycles of presentation, literature review and discussion. Summary papers were prepared by each group and collated into this position paper highlighting the research gaps, with recommendations for action. RESULTS Gaps were identified in all seven themes. General barriers to progress were lack of financial and practical resources, and poor collaboration between disciplines. Critical gaps in each theme included: (1) genetics (knowledge of genetic changes, their effects and interactions); (2) initiation of breast cancer (how developmental signalling pathways cause ductal elongation and branching at the cellular level and influence stem cell dynamics, and how their disruption initiates tumour formation); (3) progression of breast cancer (deciphering the intracellular and extracellular regulators of early progression, tumour growth, angiogenesis and metastasis); (4) therapies and targets (understanding who develops advanced disease); (5) disease markers (incorporating intelligent trial design into all studies to ensure new treatments are tested in patient groups stratified using biomarkers); (6) prevention (strategies to prevent oestrogen-receptor negative tumours and the long-term effects of chemoprevention for oestrogen-receptor positive tumours); (7) psychosocial aspects of cancer (the use of appropriate psychosocial interventions, and the personal impact of all stages of the disease among patients from a range of ethnic and demographic backgrounds). CONCLUSION Through recommendations to address these gaps with future research, the long-term benefits to patients will include: better estimation of risk in families with breast cancer and strategies to reduce risk; better prediction of drug response and patient prognosis; improved tailoring of treatments to patient subgroups and development of new therapeutic approaches; earlier initiation of treatment; more effective use of resources for screening populations; and an enhanced experience for people with or at risk of breast cancer and their families. The challenge to funding bodies and researchers in all disciplines is to focus on these gaps and to drive advances in knowledge into improvements in patient care

    The Impact of Residential Treatment on Emotionally Disturbed Boys

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    Within the past four decades, social work has witnessed the development of increasingly specialized servicecs to children, among these a sort of “total impact therapy” generally defined as residential treatment. In conjunction with the basic social work values of the bio-psycho-social nature of human maladjustment, residential centres have attempted to help the child effect a happier adjustment to his life situation by meeting some ungratified basic need. Institutions for dependent children complimented those for custodial care of even isolation; contemporary residential treatment centres are designed to meet a broader range of needs of the child than those of forty years ago through a variety of approaches, often referred to as milieu therapy. Consideration of the common needs of children is basic to questions concerning the place of institutional treatment and the particular type of child for which this social work service is the most appropriate one. The residential treatment centre addresses the whole gamut of a child’s needs from physical care to rehabilitation. Exposure to, and participation in, a group life experience simulating as closely as possible the family or community life experience is the element differentiating residential care from other treatment modes. By involvement in the realities of his daily situation and the working through or resolution of these, the child is helped to cope with his own growth and development—physical, emotional, and social. Problems and questions examined in this paper revolve around the residential treatment centre defined vaguely by the Child Welfare League of America as “A building....maintained and operated by a chartered agency, organization or institution, whose main purpose is to provide shelter and care to a group of unrelated children and youths up to eighteen years of age.” More specifically, the concern for research, the proposal and plans for implementation are focused on Mount St. Joseph, an autonomous, non-profit institution providing care for boys with moderate to severe emotional disturbances
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