Medical imaging analysis with artificial neural networks

Given that neural networks have been widely reported in the research community of medical imaging, we provide a focused literature survey on recent neural network developments in computer-aided diagnosis, medical image segmentation and edge detection towards visual content analysis, and medical image registration for its pre-processing and post-processing, with the aims of increasing awareness of how neural networks can be applied to these areas and to provide a foundation for further research and practical development. Representative techniques and algorithms are explained in detail to provide inspiring examples illustrating: (i) how a known neural network with fixed structure and training procedure could be applied to resolve a medical imaging problem; (ii) how medical images could be analysed, processed, and characterised by neural networks; and (iii) how neural networks could be expanded further to resolve problems relevant to medical imaging. In the concluding section, a highlight of comparisons among many neural network applications is included to provide a global view on computational intelligence with neural networks in medical imaging

Model-free functional MRI analysis based on unsupervised clustering

AbstractConventional model-based or statistical analysis methods for functional MRI (fMRI) are easy to implement, and are effective in analyzing data with simple paradigms. However, they are not applicable in situations in which patterns of neural response are complicated and when fMRI response is unknown. In this paper the “neural gas” network is adapted and rigourosly studied for analyzing fMRI data. The algorithm supports spatial connectivity aiding in the identification of activation sites in functional brain imaging. A comparison of this new method with Kohonen’s self-organizing map and with a fuzzy clustering scheme based on deterministic annealing is done in a systematic fMRI study showing comparative quantitative evaluations. The most important findings in this paper are: (1) both “neural gas” and the fuzzy clustering technique outperform Kohonen’s map in terms of identifying signal components with high correlation to the fMRI stimulus, (2) the “neural gas” outperforms the two other methods with respect to the quantization error, and (3) Kohonen’s map outperforms the two other methods in terms of computational expense. The applicability of the new algorithm is demonstrated on experimental data

Group Analysis of Self-organizing Maps based on Functional MRI using Restricted Frechet Means

Studies of functional MRI data are increasingly concerned with the estimation of differences in spatio-temporal networks across groups of subjects or experimental conditions. Unsupervised clustering and independent component analysis (ICA) have been used to identify such spatio-temporal networks. While these approaches have been useful for estimating these networks at the subject-level, comparisons over groups or experimental conditions require further methodological development. In this paper, we tackle this problem by showing how self-organizing maps (SOMs) can be compared within a Frechean inferential framework. Here, we summarize the mean SOM in each group as a Frechet mean with respect to a metric on the space of SOMs. We consider the use of different metrics, and introduce two extensions of the classical sum of minimum distance (SMD) between two SOMs, which take into account the spatio-temporal pattern of the fMRI data. The validity of these methods is illustrated on synthetic data. Through these simulations, we show that the three metrics of interest behave as expected, in the sense that the ones capturing temporal, spatial and spatio-temporal aspects of the SOMs are more likely to reach significance under simulated scenarios characterized by temporal, spatial and spatio-temporal differences, respectively. In addition, a re-analysis of a classical experiment on visually-triggered emotions demonstrates the usefulness of this methodology. In this study, the multivariate functional patterns typical of the subjects exposed to pleasant and unpleasant stimuli are found to be more similar than the ones of the subjects exposed to emotionally neutral stimuli. Taken together, these results indicate that our proposed methods can cast new light on existing data by adopting a global analytical perspective on functional MRI paradigms.Comment: 23 pages, 5 figures, 4 tables. Submitted to Neuroimag

Contribution of Exploratory Methods to the Investigation of Extended Large-Scale Brain Networks in Functional MRI: Methodologies, Results, and Challenges

A large-scale brain network can be defined as a set of segregated and integrated regions, that is, distant regions that share strong anatomical connections and functional interactions. Data-driven investigation of such networks has recently received a great deal of attention in blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI). We here review the rationale for such an investigation, the methods used, the results obtained, and also discuss some issues that have to be faced for an efficient exploration

Kidney segmentation in 4-dimensional dynamic contrast- enhanced MR images : A physiological approach

Master'sMASTER OF ENGINEERIN

Identifying Functional Profiles of Challenging Behaviors in Autism Spectrum Disorder with Unsupervised Machine Learning

Machine learning and deep learning methods are becoming increasingly used in the understanding, identification, and improvement of the diagnosis and treatment of Autism Spectrum Disorder. People with ASD often exemplify challenging behaviors that can put their safety, education, and general quality of life at risk. Challenging behaviors are driven by one of four functions. The combination of common occurrences of challenging behaviors and their respective behavioral functions are unique to the individual and circumstance, and the most successful therapies account for both challenging behaviors and their respective functions. Therefore, it is important that research is done on these concepts to lead to improvements in therapy and outcomes. In this thesis, we apply a cluster analysis to a sample of 1,416 individuals with Autism Spectrum Disorder. The aim is to find groupings of patients based on the relative frequency of each unique challenging behavior and function pair. As the first machine learning study to focus on combining the behavioral functions and challenging behaviors of ASD, we find that there are some patterns to be found based on eight identified clusters. The results of the study could impact the way that treatment and therapy plans are paved for children with Autism Spectrum Disorder