81 research outputs found
Using Feature Extraction From Deep Convolutional Neural Networks for Pathological Image Analysis and Its Visual Interpretability
This dissertation presents a computer-aided diagnosis (CAD) system using deep learning approaches for lesion detection and classification on whole-slide images (WSIs) with breast cancer. The deep features being distinguishing in classification from the convolutional neural networks (CNN) are demonstrated in this study to provide comprehensive interpretability for the proposed CAD system using the domain knowledge in pathology. In the experiment, a total of 186 slides of WSIs were collected and classified into three categories: Non-Carcinoma, Ductal Carcinoma in Situ (DCIS), and Invasive Ductal Carcinoma (IDC). Instead of conducting pixel-wise classification (segmentation) into three classes directly, a hierarchical framework with the multi-view scheme was designed in the proposed system that performs lesion detection for region proposal at higher magnification first and then conducts lesion classification at lower magnification for each detected lesion. The majority voting scheme was adopted to improve the error tolerance of the system in lesion-wise prediction. For all collected 186 slides, the slide-wise prediction accuracy rate strikes to 95.16% (177/186) in binary classification to predict carcinoma (malignant) or non-carcinoma (benign), and the sensitivity for cases with carcinoma reaches 96.36% (106/110). In multi-classification, the accuracy rate is 92.47% (172/186) when predicting Non-Carcinoma, DCIS, and IDC for each slide. Most importantly, the interpretability for the mechanism of the proposed CAD system is provided from the pathological perspective. The experimental results show that the morphological characteristics and co-occurrence properties learned by the deep learning models for lesion detection and classification meet the clinical rules in diagnosis. Accordingly, the pathological interpretability of the deep features not only enhances the reliability of the proposed CAD system to gain acceptance from medical specialists, but also facilitates the development of deep learning frameworks for various tasks in pathology
A new deep convolutional neural network model for classifying breast cancer histopathological images and the hyperparameter optimisation of the proposed model
Deep learning algorithms have yielded remarkable results in medical diagnosis and image analysis, besides their contribution to improvements in a number of fields such as drug discovery, time-series modelling and optimisation methods. With regard to the analysis of histopathologic breast cancer images, the similarity of those images and the presence of healthy and tumourous tissues in different areas complicate the detection and classification of tumours on whole slide images. An accurate diagnosis in a short time is a need for full treatment in breast cancer. A successful classification on breast cancer histopathological images will overcome the burden on the pathologist and reduce the subjectivity of diagnosis. In this study, we propose a deep convolutional neural network model. The model uses various algorithms (i.e., stochastic gradient descent, Nesterov accelerated gradient, adaptive gradient, RMSprop, AdaDelta and Adam) to compute the initial weight of the network and update the model parameters for faster backpropagation learning. In order to train the model with less hardware in a short time, we used the parallel computing architecture with Cuda-enabled graphics processing unit. The results indicate that the deep convolutional neural network model is an effective classification model with a high performance up to 99.05% accuracy value. Β© 2020, Springer Science+Business Media, LLC, part of Springer Nature
ΠΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΡΠΉ ΠΈΠ½ΡΠ΅Π»Π»Π΅ΠΊΡ ΠΏΡΠΈ ΠΊΠΎΠ»ΠΎΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΠΎΠΌ ΡΠ°ΠΊΠ΅: ΠΎΠ±Π·ΠΎΡ
The study objective: the study objective is to examine the use of artificial intelligence (AI) in the diagnosis, treatment, and prognosis of Colorectal Cancer (CRC) and discuss the future potential of AI in CRC. Material and Methods. The Web of Science, Scopus, PubMed, Medline, and eLIBRARY databases were used to search for the publications. A study on the application of Artificial Intelligence (AI) to the diagnosis, treatment, and prognosis of Colorectal Cancer (CRC) was discovered in more than 100 sources. In the review, data from 83 articles were incorporated. Results. The review article explores the use of artificial intelligence (AI) in medicine, specifically focusing on its applications in colorectal cancer (CRC). It discusses the stages of AI development for CRC, including molecular understanding, image-based diagnosis, drug design, and individualized treatment. The benefits of AI in medical image analysis are highlighted, improving diagnosis accuracy and inspection quality. Challenges in AI development are addressed, such as data standardization and the interpretability of machine learning algorithms. The potential of AI in treatment decision support, precision medicine, and prognosis prediction is discussed, emphasizing the role of AI in selecting optimal treatments and improving surgical precision. Ethical and regulatory considerations in integrating AI are mentioned, including patient trust, data security, and liability in AI-assisted surgeries. The review emphasizes the importance of an AI standard system, dataset standardization, and integrating clinical knowledge into AI algorithms. Overall, the article provides an overview of the current research on AI in CRC diagnosis, treatment, and prognosis, discussing its benefits, challenges, and future prospects in improving medical outcomes.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ - ΠΎΡΠ΅Π½ΠΊΠ° Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠ΅ΠΉ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈΠ½ΡΠ΅Π»Π»Π΅ΠΊΡΠ° (ΠΠ) Π² Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅, Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΠΈ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΠΊΠΎΠ»ΠΎΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ° (ΠΠ Π ), Π° ΡΠ°ΠΊΠΆΠ΅ ΠΎΠ±ΡΡΠΆΠ΄Π΅Π½ΠΈΠ΅ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»Π° ΠΠ Π² Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΠΠ Π . ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ ΠΏΠΎΠΈΡΠΊ Π½Π°ΡΡΠ½ΡΡ
ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΉ Π² ΠΏΠΎΠΈΡΠΊΠΎΠ²ΡΡ
ΡΠΈΡΡΠ΅ΠΌΠ°Ρ
Web of Science, Scopus, PubMed, Medline ΠΈ eLIBRARY. ΠΡΠ»ΠΎ ΠΏΡΠΎΡΠΌΠΎΡΡΠ΅Π½ΠΎ Π±ΠΎΠ»Π΅Π΅ 100 ΠΈΡΡΠΎΡΠ½ΠΈΠΊΠΎΠ² ΠΏΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΠ Π΄Π»Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ, Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΈ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΠ Π . Π ΠΎΠ±Π·ΠΎΡ Π²ΠΊΠ»ΡΡΠ΅Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΠΈΠ· 83 ΡΡΠ°ΡΠ΅ΠΉ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ, ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π½ΠΎΠΉ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΈΡΠΊΡΡΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈΠ½ΡΠ΅Π»Π»Π΅ΠΊΡΠ° Π² ΠΌΠ΅Π΄ΠΈΡΠΈΠ½Π΅, ΠΎΡΠΎΠ±ΠΎΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΡΠ΄Π΅Π»Π΅Π½ΠΎ Π΅Π³ΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΠΏΡΠΈ ΠΊΠΎΠ»ΠΎΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΠΎΠΌ ΡΠ°ΠΊΠ΅. ΠΠ±ΡΡΠΆΠ΄Π°ΡΡΡΡ ΡΡΠ°ΠΏΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΠ ΠΏΡΠΈ ΠΠ Π , Π²ΠΊΠ»ΡΡΠ°Ρ ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΡΡ Π²Π΅ΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ, Π»ΡΡΠ΅Π²ΡΡ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΡ, ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΡ Π»Π΅ΠΊΠ°ΡΡΡΠ² ΠΈ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡΠ°Π»ΡΠ½ΠΎΠ΅ Π»Π΅ΡΠ΅Π½ΠΈΠ΅. ΠΠΎΠ΄ΡΠ΅ΡΠΊΠ½ΡΡΡ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π° ΠΠ Π² Π°Π½Π°Π»ΠΈΠ·Π΅ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΈΡ
ΠΈΠ·ΠΎΠ±ΡΠ°ΠΆΠ΅Π½ΠΈΠΉ, ΡΠ°ΠΊΠΈΡ
ΠΊΠ°ΠΊ ΠΠ’, ΠΠ Π’ ΠΈ ΠΠΠ’, ΡΡΠΎ ΠΏΠΎΠ²ΡΡΠ°Π΅Ρ ΡΠΎΡΠ½ΠΎΡΡΡ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ. Π Π°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ ΡΠ°ΠΊΠΈΠ΅ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΠ, ΠΊΠ°ΠΊ ΡΡΠ°Π½Π΄Π°ΡΡΠΈΠ·Π°ΡΠΈΡ Π΄Π°Π½Π½ΡΡ
ΠΈ ΠΈΠ½ΡΠ΅ΡΠΏΡΠ΅ΡΠΈΡΡΠ΅ΠΌΠΎΡΡΡ Π°Π»Π³ΠΎΡΠΈΡΠΌΠΎΠ² ΠΌΠ°ΡΠΈΠ½Π½ΠΎΠ³ΠΎ ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ. ΠΠΎΠ΄ΡΠ΅ΡΠΊΠΈΠ²Π°Π΅ΡΡΡ ΡΠΎΠ»Ρ ΠΠ Π² Π²ΡΠ±ΠΎΡΠ΅ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ°ΠΊΡΠΈΠΊΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ ΠΈ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π°. Π£ΡΠΈΡΡΠ²Π°ΡΡΡΡ ΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈ Π½ΠΎΡΠΌΠ°ΡΠΈΠ²Π½ΡΠ΅ Π°ΡΠΏΠ΅ΠΊΡΡ ΠΠ, Π²ΠΊΠ»ΡΡΠ°Ρ Π΄ΠΎΠ²Π΅ΡΠΈΠ΅ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², Π±Π΅Π·ΠΎΠΏΠ°ΡΠ½ΠΎΡΡΡ Π΄Π°Π½Π½ΡΡ
ΠΈ ΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎΡΡΡ Π² ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΉ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΠΠ. ΠΠ±ΡΡΠΆΠ΄Π°ΡΡΡΡ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π° ΠΠ Π² Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅, Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΠΈ ΠΏΡΠΎΠ³Π½ΠΎΠ·ΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ ΠΊΠΎΠ»ΠΎΡΠ΅ΠΊΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΠ°, ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ ΠΈ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ ΡΠ»ΡΡΡΠ΅Π½ΠΈΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² Π»Π΅ΡΠ΅Π½ΠΈΡ
A Review on Classification of White Blood Cells Using Machine Learning Models
The machine learning (ML) and deep learning (DL) models contribute to
exceptional medical image analysis improvement. The models enhance the
prediction and improve the accuracy by prediction and classification. It helps
the hematologist to diagnose the blood cancer and brain tumor based on
calculations and facts. This review focuses on an in-depth analysis of modern
techniques applied in the domain of medical image analysis of white blood cell
classification. For this review, the methodologies are discussed that have used
blood smear images, magnetic resonance imaging (MRI), X-rays, and similar
medical imaging domains. The main impact of this review is to present a
detailed analysis of machine learning techniques applied for the classification
of white blood cells (WBCs). This analysis provides valuable insight, such as
the most widely used techniques and best-performing white blood cell
classification methods. It was found that in recent decades researchers have
been using ML and DL for white blood cell classification, but there are still
some challenges. 1) Availability of the dataset is the main challenge, and it
could be resolved using data augmentation techniques. 2) Medical training of
researchers is recommended to help them understand the structure of white blood
cells and select appropriate classification models. 3) Advanced DL networks
such as Generative Adversarial Networks, R-CNN, Fast R-CNN, and faster R-CNN
can also be used in future techniques.Comment: 23 page
A survey on automated detection and classification of acute leukemia and WBCs in microscopic blood cells
Leukemia (blood cancer) is an unusual spread of White Blood Cells or
Leukocytes (WBCs) in the bone marrow and blood. Pathologists can diagnose
leukemia by looking at a person's blood sample under a microscope. They
identify and categorize leukemia by counting various blood cells and
morphological features. This technique is time-consuming for the prediction of
leukemia. The pathologist's professional skills and experiences may be
affecting this procedure, too. In computer vision, traditional machine learning
and deep learning techniques are practical roadmaps that increase the accuracy
and speed in diagnosing and classifying medical images such as microscopic
blood cells. This paper provides a comprehensive analysis of the detection and
classification of acute leukemia and WBCs in the microscopic blood cells.
First, we have divided the previous works into six categories based on the
output of the models. Then, we describe various steps of detection and
classification of acute leukemia and WBCs, including Data Augmentation,
Preprocessing, Segmentation, Feature Extraction, Feature Selection (Reduction),
Classification, and focus on classification step in the methods. Finally, we
divide automated detection and classification of acute leukemia and WBCs into
three categories, including traditional, Deep Neural Network (DNN), and mixture
(traditional and DNN) methods based on the type of classifier in the
classification step and analyze them. The results of this study show that in
the diagnosis and classification of acute leukemia and WBCs, the Support Vector
Machine (SVM) classifier in traditional machine learning models and
Convolutional Neural Network (CNN) classifier in deep learning models have
widely employed. The performance metrics of the models that use these
classifiers compared to the others model are higher
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