Multiple Interacting Rotational, Focal, and Wavelet Activities at Heterogeneous Tissue in Atrial Fibrillation

Despite extensive research, the mechanisms of atrial fibrillation are still not clear. The central scientific question is what are the necessary conditions for the induction and maintenance of atrial fibrillation. This thesis presents simulation-, clinical- and experimental- studies of atrial fibrillation beginning from simplified to complex models. Main topics are the understanding of influence parameters of signal recordings, understanding the impact of fibrosis on the development of AF sources, and the development of new methods and catheter designs for the detection of AF sources

Modeling Human Atrial Patho-Electrophysiology from Ion Channels to ECG - Substrates, Pharmacology, Vulnerability, and P-Waves

Half of the patients suffering from atrial fibrillation (AF) cannot be treated adequately, today. This book presents multi-scale computational methods to advance our understanding of patho-mechanisms, to improve the diagnosis of patients harboring an arrhythmogenic substrate, and to tailor therapy. The modeling pipeline ranges from ion channels on the subcellular level up to the ECG on the body surface. The tailored therapeutic approaches carry the potential to reduce the burden of AF