Convolutional Sparse Kernel Network for Unsupervised Medical Image Analysis

The availability of large-scale annotated image datasets and recent advances in supervised deep learning methods enable the end-to-end derivation of representative image features that can impact a variety of image analysis problems. Such supervised approaches, however, are difficult to implement in the medical domain where large volumes of labelled data are difficult to obtain due to the complexity of manual annotation and inter- and intra-observer variability in label assignment. We propose a new convolutional sparse kernel network (CSKN), which is a hierarchical unsupervised feature learning framework that addresses the challenge of learning representative visual features in medical image analysis domains where there is a lack of annotated training data. Our framework has three contributions: (i) We extend kernel learning to identify and represent invariant features across image sub-patches in an unsupervised manner. (ii) We initialise our kernel learning with a layer-wise pre-training scheme that leverages the sparsity inherent in medical images to extract initial discriminative features. (iii) We adapt a multi-scale spatial pyramid pooling (SPP) framework to capture subtle geometric differences between learned visual features. We evaluated our framework in medical image retrieval and classification on three public datasets. Our results show that our CSKN had better accuracy when compared to other conventional unsupervised methods and comparable accuracy to methods that used state-of-the-art supervised convolutional neural networks (CNNs). Our findings indicate that our unsupervised CSKN provides an opportunity to leverage unannotated big data in medical imaging repositories.Comment: Accepted by Medical Image Analysis (with a new title 'Convolutional Sparse Kernel Network for Unsupervised Medical Image Analysis'). The manuscript is available from following link (https://doi.org/10.1016/j.media.2019.06.005

Assisting the training of deep neural networks with applications to computer vision

[eng] Deep learning has recently been enjoying an increasing popularity due to its success in solving challenging tasks. In particular, deep learning has proven to be effective in a large variety of computer vision tasks, such as image classification, object recognition and image parsing. Contrary to previous research, which required engineered feature representations, designed by experts, in order to succeed, deep learning attempts to learn representation hierarchies automatically from data. More recently, the trend has been to go deeper with representation hierarchies. Learning (very) deep representation hierarchies is a challenging task, which involves the optimization of highly non- convex functions. Therefore, the search for algorithms to ease the learning of (very) deep representation hierarchies from data is extensive and ongoing. In this thesis, we tackle the challenging problem of easing the learning of (very) deep representation hierarchies. We present a hyper-parameter free, off-the-shelf, simple and fast unsupervised algorithm to discover hidden structure from the input data by enforcing a very strong form of sparsity. We study the applicability and potential of the algorithm to learn representations of varying depth in a handful of applications and domains, highlighting the ability of the algorithm to provide discriminative feature representations that are able to achieve top performance. Yet, while emphasizing the great value of unsupervised learning methods when labeled data is scarce, the recent industrial success of deep learning has revolved around supervised learning. Supervised learning is currently the focus of many recent research advances, which have shown to excel at many computer vision tasks. Top performing systems often involve very large and deep models, which are not well suited for applications with time or memory limitations. More in line with the current trends, we engage in making top performing models more efficient, by designing very deep and thin models. Since training such very deep models still appears to be a challenging task, we introduce a novel algorithm that guides the training of very thin and deep models by hinting their intermediate representations. Very deep and thin models trained by the proposed algorithm end up extracting feature representations that are comparable or even better performing than the ones extracted by large state-of-the-art models, while compellingly reducing the time and memory consumption of the model