Reciprocal intronic and exonic histone modification regions in humans.

While much attention has been focused on chromatin at promoters and exons, human genes are mostly composed of intronic sequences. Analyzing published surveys of nucleosomes and 41 chromatin marks in humans, we identified histone modifications specifically associated with 5' intronic sequences, distinguishable from promoter marks and bulk nucleosomes. These intronic marks were spatially reciprocal to trimethylated histone H3 Lys36 (H3K36me3), typically transitioning near internal exons. Several marks transitioned near bona fide exons, but not near nucleosomes at exon-like sequences. Therefore, we examined whether splicing affects histone marking. Even with considerable changes in regulated alternative splicing, histone marks were stable. Notably, these findings are consistent with exon definition influencing histone marks. In summary, we show that the location of many intragenic marks in humans can be distilled into a simple organizing principle: association with 5' intronic or 3' exonic regions

Miss Marks Is Dead

Fiction by Shirley Swartz

High Water Marks

Incentive fees for money managers are frequently accompanied by high-water mark provisions that condition the payment of the performance fee upon exceeding the previously achieved maximum share value. In this paper, we show that hedge fund performance fees are valuable to money managers, and conversely, represent a claim on a significant proportion of investor wealth. The high-water mark provisions in these contracts limit the value of the performance fees. We provide a closed-form solution to the cost of the high-water mark contract under certain conditions. Our results provide a framework for valuation of a hedge fund management company.

Group study of an 'undercover' test for visuospatial neglect: Invisible cancellation can reveal more neglect than standard cancellation

Visual neglect is a relatively common deficit after brain damage, particularly strokes. Cancellation tests provide standard clinical measures of neglect severity and deficits in daily life. A recent single-case study introduced a new variation on standard cancellation. Instead of making a visible mark on each target found, the patient made invisible marks (recorded with carbon paper underneath, for later scoring). Such invisible cancellation was found to reveal more neglect than cancellation with visible marks. Here we test the generality of this. Twenty three successive cases with suspected neglect each performed cancellation with visible or invisible marks. Neglect of contralesional targets was more pronounced with invisible marks. Indeed, about half of the patients only showed neglect in this version. For cases showing more neglect with invisible marks, stronger neglect of contralesional targets correlated with more revisits to ipsilesional targets for making additional invisible marks upon them. These results indicate that cancellation with invisible marks can reveal more neglect than standard cancellation with visible marks, while still providing a practical bedside test. Our observations may be consistent with recent proposals that demands on spatial working memory (required to keep track of previously found items only when marked invisibly) can exacerbate spatial neglect

The German monetary unification (Gmu): converting marks to d-marks

Monetary policy - Germany ; Germany

Polish and Russian rural areas in transition. Land and demography

Rozdział z: Functioning of the Local Production Systems in Central and Eastern European Countries and Siberia. Case Studies and Comparative Studies, ed. Mariusz E. Sokołowicz.The aim of this article is to present the main changes in the structure of the space and demographic processes of rural areas in Poland and Russia, taking place after 1990. Though both countries are completely different (e.g. as for the perspective of scale, the position in the international arena, the forms of agricultural production, etc.), they were subjected – within a similar period of time – to the systemic change and are faced with multiple problems of the socio-economic transition period. The terms of the environment, including mainly political, but also historical and cultural factors, caused that Poland and Russia have chosen other paths of transformation, yielding diverse results. Above all, the two countries perceive the role of the rural areas in the society in a different way.Monograph financed under a contract of execution of the international scientific project within 7th Framework Programme of the European Union, co-financed by Polish Ministry of Science and Higher Education (title: “Functioning of the Local Production Systems in the Conditions of Economic Crisis (Comparative Analysis and Benchmarking for the EU and Beyond”)). Monografia sfinansowana w oparciu o umowę o wykonanie projektu między narodowego w ramach 7. Programu Ramowego UE, współfinansowanego ze środków Ministerstwa Nauki i Szkolnictwa Wyższego (tytuł projektu: „Funkcjonowanie lokalnych systemów produkcyjnych w warunkach kryzysu gospodarczego (analiza porównawcza i benchmarking w wybranych krajach UE oraz krajach trzecich”))

Rock Marks Vineyard Site Article

The location of Bjelland Vineyards is marked by a rock in Roseburg, Oregon. In 1970, Bjelland Vineyards began planning construction of a winery at the vineyard site. At this time, Bjelland Vineyards is one of the largest vineyards, producing over 1,200 gallons of varietals such as Cabernet Sauvignon, Gamay Beaujolais, Pinot Chardonnay, Pinot Noir, Pinot Blanc, Zinfandel, Gerwürtztraminer, Semillon, and Sauvignon Blanc. The article is accompanied by an advertisement for special occasion sales and samples at Bjelland Vineyards

Drugs and oil flow through the Eagle Ford Shale

textThis report is a work of original reporting which investigates the proliferation of drug use and drug trafficking in the Eagle Ford Shale, a region of heavy oil and gas development in South Texas. Since 2008, the Eagle Ford Shale has seen an influx of people, money, and new infrastructure. This has created a "perfect storm" for drug traffickers. The region is historically poor and sparsely populated, and local law enforcement agencies find themselves unprepared to handle the growing drug problem in their communities.Journalis

Specialty Programs Earn High Marks

What\u27s so special about the School of Law\u27s specialty programs? Is it A) they are nationally acclaimed, B) they attract top-notch students and faculty, C) they provide representation for those who can\u27t afford to hire an attorney, or D) all of the above