Quantitative assessment of intrinsic noise for visually guided behaviour in zebrafish

Supported by Royal Society of London (University Research Fellowship), Medical Research Council (New Investigator Research Grant) and CNRS.Peer reviewedPostprin

ToScA North America (6 – 8 June 2017, The University of Texas, Austin, TX) Program

ToScA North America will address key areas of science, including Multi-modal Imaging, Geosciences, Forensics, Increasing Contrast, Educational Outreach, Data, Materials Science and Medical and Biological Science.University of Texas High-Resolution X-ray CT Facility (UTCT); Jackson School of Geosciences, The University of Texas at Austin; Natural History Museum (London); Royal Microscopical Society (Oxford, UK)Geological Science

Purinergic signaling in the gastrointestinal tract

Geoffrey Burnstock completed a BSc at King's College London and a PhD at University College London. He held postdoctoral fellowships with Wilhelm Feldberg (National Institute for Medical Research), Edith Bülbring (University of Oxford) and C. Ladd Prosser (University of Illinois). He was appointed to a Senior Lectureship in Melbourne University in 1959 and became Professor and Chairman of Zoology in 1964. In 1975 he became Head of Department of Anatomy and Developmental Biology at UCL and Convenor of the Center of Neuroscience. He has been Director of the Autonomic Neuroscience Institute at the Royal Free Hospital School of Medicine since 1997. He was elected to the Australian Academy of Sciences in 1971, the Royal Society in 1986, the Academy of Medical Sciences in 1998 and an Honorary Fellow of the Royal College of Surgeons and the Royal College of Physicians in 1999 and 2000. He was awarded the Royal Society Gold Medal in 2000. He is editor-in-chief of the journals Autonomic Neuroscience and Purinergic Signalling and on the editorial boards of many other journals. Geoffrey Burnstock's major research interest has been autonomic neurotransmission and he is best known for his seminal discovery of purinergic transmission and receptors, their signaling pathways and functional relevance. He has supervised over 100 PhD and MD students and published over 1400 original papers, re-views and books. He was first in the Institute of Scientific Information list of most cited scientists in Pharmacology and Toxicology from 1994-2004 [59.083 citations (March 2011) and an h-index of 109]

MRL1: David Livingstone Papers, 1856; 1957

David Livingstone was a Congregationalist medical missionary assigned to Africa by London Missionary Society, continued exploration with Royal Geographical Society. Collection contains single letter and poster of postcards from Scottish National Memorial to Livingstone in Blantyre, Scotland

Blob-ology and biology of cryo-EM: an interview with Helen Saibil

Helen Saibil is Bernal Professor of Structural Biology at Birkbeck, University of London. After undergraduate work at McGill University, Canada, Helen moved to London for her PhD at Kings College. After stints at CEA Grenoble and the University of Oxford, she moved to Birkbeck where her lab studies the operation of macromolecular machinery—including molecular chaperones, protein folding/misfolding, and host cell interactions with pathogens. Helen is a Fellow of the Royal Society, Fellow of the Academy of Medical Sciences, and an Honorary Member of both the British Biophysical Society and the Royal Microscopical Society. She talked to us about the background, recent developments, and future prospects in cryo-electron microscopy

“Desirous of Improvements in Medicine : Pupils and Practitioners in the Medical Societies at Guy\u27s and St. Bartholomews Hospitals, 1795–1815

Guy\u27s Hospital Physical Society and St. Bartholomew\u27s Hospital Medical and Philosophical Society served important educational and professional functions in London between 1795 and 1815. They provided the opportunity for discussing everyday problems, sharing new discoveries and encouraging pupils to exploit fully their hospital experiences. They allowed hospital men to pontificate at times, but also to support the efforts of local practitioners and ambitious students. While not improving medicine in the sense of directing research or organizing clinical investigations, they did help medical men at all levels to think about their experiences before their observations were lost in the demands of the next case. Perhaps most important, the societies fostered the medical communities associated with three of the great London hospitals. They did this by providing links between pupils and practitioners from different hospitals, different kinds of practice, and different professional levels

“Desirous of Improvements in Medicine : Pupils and Practitioners in the Medical Societies at Guy\u27s and St. Bartholomews Hospitals, 1795–1815

Guy\u27s Hospital Physical Society and St. Bartholomew\u27s Hospital Medical and Philosophical Society served important educational and professional functions in London between 1795 and 1815. They provided the opportunity for discussing everyday problems, sharing new discoveries and encouraging pupils to exploit fully their hospital experiences. They allowed hospital men to pontificate at times, but also to support the efforts of local practitioners and ambitious students. While not improving medicine in the sense of directing research or organizing clinical investigations, they did help medical men at all levels to think about their experiences before their observations were lost in the demands of the next case. Perhaps most important, the societies fostered the medical communities associated with three of the great London hospitals. They did this by providing links between pupils and practitioners from different hospitals, different kinds of practice, and different professional levels

Book Reviews

Book Review 1Book Title:  The Histogenesis of Thyroid CancerBook Author: N SimionescuIllustrated. £9.0.0. London: William Heinemann Medical Books. 1970Book Review 2Book Title: The Hypertensive Vascular Crisis. An experimental studyBook Author: F.B. ByromIllustrated. £1.10.0. London: William Heinemann Medical Books. 1969Book Review 3Book Title: The Problems of Species Difference and Statistics in Toxicology. Vol. XI. Proceedings of the European Society for the Study of Drug ToxicityBook Authors: S.B. de C. Baker, J. Tripod & J. Jacob (Eds.)Pp. 275. Illustrated. £7.7.0. Amsterdam: Excerpta Medica. 1970Book Review 4Book Title: Respiratory DiseasesBook Author: J CroftonPp. xiv + 719. £7.15.0. Oxford en Edinburgh: Blackwell Scientific Publications. 1969.Book Review 5Book Title: Psychedelic Drugs. Proceedings of a Hahnemann Medical College and Hospital SymposiumBook Author: R.E. Hicks & P.J. Fick (Eds.)Pp. xiii + 249. $16.75. New York and London. Grune & Stratton. 196

Microfluidics for Energy Applications

This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community, www.nanopaprika.eu.Microfluidic methods developed primarily for medical applications have much to offer energy applications. This short paper will provide the motivation and outline my group’s recent work in two such areas: (1) microfluidics and optics for bioenergy and (2) microfluidics for carbon management. Full details will be provided in talk. Within the bioenergy theme, we are developing photobioreactor architectures that leverage micro-optics and microfluidics to cater both light and fluids to maximize productivity of microalgae. Within the carbon management theme we are developing a suite of methods to study porescale transport and reactivity in carbon sequestration and enhanced oil recovery. Results indicate potential for order of magnitude gains in photobioreactor technology and a 100-fold improvement over current subsurface fluid transport analysis methods

Diagnostics of Stresses and Strains of Hard Bio-tissues in vivo

This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the Process Intensification Network, the Institution of Mechanical Engineers, the Heat Transfer Society, HEXAG - the Heat Exchange Action Group, and the Energy Institute, ASME Press, LCN London Centre for Nanotechnology, UCL University College London, UCL Engineering, the International NanoScience Community, www.nanopaprika.eu.The formation and dynamics of bio-speckle fields formed by hard bio-tissues of the oral cavity in vivo irradiated with low-intensity laser light are analyzed. Novel experimental methods for diagnostics of the stressed-strained state of the dental system and orthodontic and orthopedic structures based on speckle technologies and cross-correlation analysis of bio-speckle fields are described. The cross-correlation analysis of the laser bio-speckle fields permits quantitative determination of the micro displacement of the hard biotissues and orthodontic and orthopedic structural elements in the range from 1 to 100 μm with submicron accuracy and a spatial resolution of up to 50 μm. This suffices for detecting micro deviations of the indices of the stressed-strained state of the elements, used in medical orthodontic practice, and their changes with time in the period of the investigation and after a functional test