Evaluating Modelling Approaches for Medical Image Annotations

Information system designers face many challenges with regards to selecting appropriate semantic technologies and deciding on a modeling approach for their system. However, there is no clear methodology yet to evaluate “semantically enriched” information systems. In this paper we present a case study on different modeling approaches for annotating medical images and introduce a conceptual framework that can be used to analyze the fitness of information systems and help designers to spot the strengths and weaknesses of various modeling approaches as well as managing trade-offs between modeling effort and their potential benefits

Monomial, Gorenstein and Bass Orders

In this article we study a class of orders called {\it monomial orders} in a central simple algebra over a non-Archimedean local field. Monomial orders are easily represented and they may be also viewed as a direct generalization of Eichler orders in quaternion algebras. A criterion for monomial orders to be Gorenstein or to be Bass is given. It is shown that a monomial order is Bass if and only if it is either a hereditary or an Eichler order of period two.Comment: 13 pages; fix typos in the proof of Theorem 3.

Dark energy, cosmological constant and neutrino mixing

The today estimated value of dark energy can be achieved by the vacuum condensate induced by neutrino mixing phenomenon. Such a tiny value is recovered for a cut-off of the order of Planck scale and it is linked to the sub eV neutrino mass scale. Contributions to dark energy from auxiliary fields or mechanisms are not necessary in this approach.Comment: 10 pages, 2 figure

Prepotentials of N=2 SU(2) Yang-Mills theories coupled with massive matter multiplets

We discuss N=2 SU(2) Yang-Mills gauge theories coupled with N_f (=2,3) massive hypermultiplets in the weak coupling limit. We determine the exact massive prepotentials and the monodromy matrices around the weak coupling limit. We also study that the double scaling limit of these massive theories and find that the massive N_f -1 theory can be obtained from the massive N_f theory. New formulae for the massive prepotentials and the monodromy matrices are proposed. In these formulae, N_f dependences are clarified.Comment: A version is published in J. Math. Phys. 38 (1997) 68

Experiment for Testing Special Relativity Theory

An experiment aimed at testing special relativity via a comparison of the velocity of a non matter particle (annihilation photon) with the velocity of the matter particle (Compton electron) produced by the second annihilation photon from the decay Na-22(beta^+)Ne-22 is proposed.Comment: 7 pages, 1 figure, Report on the Conference of Nuclear Physics Division of Russian Academy of Science "Physics of Fundamental Interactions", ITEP, Moscow, November 26-30, 200

Enumeration of graphs with a heavy-tailed degree sequence

In this paper, we asymptotically enumerate graphs with a given degree sequence d=(d_1,...,d_n) satisfying restrictions designed to permit heavy-tailed sequences in the sparse case (i.e. where the average degree is rather small). Our general result requires upper bounds on functions of M_k= \sum_{i=1}^n [d_i]_k for a few small integers k\ge 1. Note that M_1 is simply the total degree of the graphs. As special cases, we asymptotically enumerate graphs with (i) degree sequences satisfying M_2=o(M_1^{ 9/8}); (ii) degree sequences following a power law with parameter gamma>5/2; (iii) power-law degree sequences that mimic independent power-law "degrees" with parameter gamma>1+\sqrt{3}\approx 2.732; (iv) degree sequences following a certain "long-tailed" power law; (v) certain bi-valued sequences. A previous result on sparse graphs by McKay and the second author applies to a wide range of degree sequences but requires Delta =o(M_1^{1/3}), where Delta is the maximum degree. Our new result applies in some cases when Delta is only barely o(M_1^ {3/5}). Case (i) above generalises a result of Janson which requires M_2=O(M_1) (and hence M_1=O(n) and Delta=O(n^{1/2})). Cases (ii) and (iii) provide the first asymptotic enumeration results applicable to degree sequences of real-world networks following a power law, for which it has been empirically observed that 2<gamma<3.Comment: 34 page

Control of human adenovirus type 5 gene expression by cellular Daxx/ATRX chromatin-associated complexes

Death domain–associated protein (Daxx) cooperates with X-linked α-thalassaemia retardation syndrome protein (ATRX), a putative member of the sucrose non-fermentable 2 family of ATP-dependent chromatin-remodelling proteins, acting as the core ATPase subunit in this complex, whereas Daxx is the targeting factor, leading to histone deacetylase recruitment, H3.3 deposition and transcriptional repression of cellular promoters. Despite recent findings on the fundamental importance of chromatin modification in host-cell gene regulation, it remains unclear whether adenovirus type 5 (Ad5) transcription is regulated by cellular chromatin remodelling to allow efficient virus gene expression. Here, we focus on the repressive role of the Daxx/ATRX complex during Ad5 replication, which depends on intact protein–protein interaction, as negative regulation could be relieved with a Daxx mutant that is unable to interact with ATRX. To ensure efficient viral replication, Ad5 E1B-55K protein inhibits Daxx and targets ATRX for proteasomal degradation in cooperation with early region 4 open reading frame protein 6 and cellular components of a cullin-dependent E3-ubiquitin ligase. Our studies illustrate the importance and diversity of viral factors antagonizing Daxx/ATRX-mediated repression of viral gene expression and shed new light on the modulation of cellular chromatin remodelling factors by Ad5. We show for the first time that cellular Daxx/ATRX chromatin remodelling complexes play essential roles in Ad gene expression and illustrate the importance of early viral proteins to counteract cellular chromatin remodelling