Formation of visual memories controlled by gamma power phase-locked to alpha oscillations

Neuronal oscillations provide a window for understanding the brain dynamics that organize the flow of information from sensory to memory areas. While it has been suggested that gamma power reflects feedforward processing and alpha oscillations feedback control, it remains unknown how these oscillations dynamically interact. Magnetoencephalography (MEG) data was acquired from healthy subjects who were cued to either remember or not remember presented pictures. Our analysis revealed that in anticipation of a picture to be remembered, alpha power decreased while the cross-frequency coupling between gamma power and alpha phase increased. A measure of directionality between alpha phase and gamma power predicted individual ability to encode memory: stronger control of alpha phase over gamma power was associated with better memory. These findings demonstrate that encoding of visual information is reflected by a state determined by the interaction between alpha and gamma activity

Inhibition of alpha oscillations through serotonin-2A receptor activation underlies the visual effects of ayahuasca in humans

Ayahuasca is an Amazonian psychotropic plant tea typically obtained from two plants, Banisteriopsis caapi and Psychotria viridis. It contains the psychedelic 5-HT2A and sigma-1 agonist N,N-dimethyltryptamine (DMT) plus ß-carboline alkaloids with monoamine-oxidase (MAO)-inhibiting properties. Although the psychoactive effects of ayahuasca have commonly been attributed solely to agonism at the 5-HT2A receptor, the molecular target of classical psychedelics, this has not been tested experimentally. Here we wished to study the contribution of the 5-HT2A receptor to the neurophysiological and psychological effects of ayahuasca in humans. We measured drug-induced changes in spontaneous brain oscillations and subjective effects in a double-blind randomized placebo-controlled study involving the oral administration of ayahuasca (0.75 mg DMT/kg body weight) and the 5-HT2A antagonist ketanserin (40 mg). Twelve healthy, experienced psychedelic users (5 females) participated in four experimental sessions in which they received the following drug combinations: placebo+placebo, placebo+ayahuasca, ketanserin+placebo and ketanserin+ayahuasca. Ayahuasca induced EEG power decreases in the delta, theta and alpha frequency bands. Current density in alpha-band oscillations in parietal and occipital cortex was inversely correlated with the intensity of visual imagery induced by ayahuasca. Pretreatment with ketanserin inhibited neurophysiological modifications, reduced the correlation between alpha and visual effects, and attenuated the intensity of the subjective experience. These findings suggest that despite the chemical complexity of ayahuasca, 5-HT2A activation plays a key role in the neurophysiological and visual effects of ayahuasca in humans.Postprint (published version

As light as your footsteps: altering walking sounds to change perceived body weight, emotional state and gait

An ever more sedentary lifestyle is a serious problem in our society. Enhancing people’s exercise adherence through technology remains an important research challenge. We propose a novel approach for a system supporting walking that draws from basic findings in neuroscience research. Our shoe-based prototype senses a person’s footsteps and alters in real-time the frequency spectra of the sound they produce while walking. The resulting sounds are consistent with those produced by either a lighter or heavier body. Our user study showed that modified walking sounds change one’s own perceived body weight and lead to a related gait pattern. In particular, augmenting the high frequencies of the sound leads to the perception of having a thinner body and enhances the motivation for physical activity inducing a more dynamic swing and a shorter heel strike. We here discuss the opportunities and the questions our findings open

Alpha Rhythms Reveal When and Where Item and Associative Memories Are Retrieved

Memories for past experiences can range from vague recognition to full-blown recall of associated details. Electroencephalography has shown that recall signals unfold a few hundred milliseconds after simple recognition, but has only provided limited insights into the underlying brain networks. Functional magnetic resonance imaging (fMRI) has revealed a “core recollection network” (CRN) centered on posterior parietal and medial temporal lobe regions, but the temporal dynamics of these regions during retrieval remain largely unknown. Here we used Magnetoencephalography in a memory paradigm assessing correct rejection (CR) of lures, item recognition (IR) and associative recall (AR) in human participants of both sexes. We found that power decreases in the alpha frequency band (10–12 Hz) systematically track different mnemonic outcomes in both time and space: Over left posterior sensors, alpha power decreased in a stepwise fashion from 500 ms onward, first from CR to IR and then from IR to AR. When projecting alpha power into source space, the CRN known from fMRI studies emerged, including posterior parietal cortex (PPC) and hippocampus. While PPC showed a monotonic change across conditions, hippocampal effects were specific to recall. These region-specific effects were corroborated by a separate fMRI dataset. Importantly, alpha power time courses revealed a temporal dissociation between item and associative memory in hippocampus and PPC, with earlier AR effects in hippocampus. Our data thus link engagement of the CRN to the temporal dynamics of episodic memory and highlight the role of alpha rhythms in revealing when and where different types of memories are retrieved

Development and Human Factors Evaluation of a Portable Auditory Localization Acclimation Training System

Auditory situation awareness (ASA) is essential for safety and survivability in military operations where many of the hazards are not immediately visible. Unfortunately, the Hearing Protection Devices (HPDs) required to operate in these environments can impede auditory localization performance. Promisingly, recent studies have exhibited the plasticity of the human auditory system by demonstrating that training can improve auditory localization ability while wearing HPDs, including military Tactical Communications and Protective Systems (TCAPS). As a result, the U.S. military identified the need for a portable system capable of imparting auditory localization acquisition skills at similar levels to those demonstrated in laboratory environments. The purpose of this investigation was to develop and validate a Portable Auditory Localization Acclimation Training (PALAT) system equipped with an improved training protocol against a proven laboratory grade system referred to as the DRILCOM system and subsequently evaluate the transfer-of-training benefit in a field environment. In Phase I, a systems decision process was used to develop a prototype PALAT system consisting of an expandable frame housing 32-loudspeakers operated by a user-controlled tablet computer capable of reproducing acoustically accurate localization cues similar to the DRILCOM system. Phase II used a within-subjects human factors experiment to validate whether the PALAT system could impart similar auditory localization training benefits as the DRILCOM system. Results showed no significant difference between the two localization training systems at each stage of training or in training rates for the open ear and with two TCAPS devices. The PALAT system also demonstrated the ability to detect differences in localization accuracy between listening conditions in the same manner as the DRILCOM system. Participant ratings indicated no perceived difference in localization training benefit but significantly preferred the PALAT system user interface which was specifically designed to improve usability features to meet requirements of a user operable system. The Phase III investigation evaluated the transfer-of-training benefit imparted by the PALAT system using a broadband stimulus to a field environment using gunshot stimulus. Training under the open ear and in-the-ear TCAPS resulted in significant differences between the trained and untrained groups from in-office pretest to in-field posttest

Development and Human Factors Evaluation of a Portable Auditory Localization Acclimation Training System

Auditory situation awareness (ASA) is essential for safety and survivability in military operations where many of the hazards are not immediately visible. Unfortunately, the Hearing Protection Devices (HPDs) required to operate in these environments can impede auditory localization performance. Promisingly, recent studies have exhibited the plasticity of the human auditory system by demonstrating that training can improve auditory localization ability while wearing HPDs, including military Tactical Communications and Protective Systems (TCAPS). As a result, the U.S. military identified the need for a portable system capable of imparting auditory localization acquisition skills at similar levels to those demonstrated in laboratory environments. The purpose of this investigation was to develop and validate a Portable Auditory Localization Acclimation Training (PALAT) system equipped with an improved training protocol against a proven laboratory grade system referred to as the DRILCOM system and subsequently evaluate the transfer-of-training benefit in a field environment. In Phase I, a systems decision process was used to develop a prototype PALAT system consisting of an expandable frame housing 32-loudspeakers operated by a user-controlled tablet computer capable of reproducing acoustically accurate localization cues similar to the DRILCOM system. Phase II used a within-subjects human factors experiment to validate whether the PALAT system could impart similar auditory localization training benefits as the DRILCOM system. Results showed no significant difference between the two localization training systems at each stage of training or in training rates for the open ear and with two TCAPS devices. The PALAT system also demonstrated the ability to detect differences in localization accuracy between listening conditions in the same manner as the DRILCOM system. Participant ratings indicated no perceived difference in localization training benefit but significantly preferred the PALAT system user interface which was specifically designed to improve usability features to meet requirements of a user operable system. The Phase III investigation evaluated the transfer-of-training benefit imparted by the PALAT system using a broadband stimulus to a field environment using gunshot stimulus. Training under the open ear and in-the-ear TCAPS resulted in significant differences between the trained and untrained groups from in-office pretest to in-field posttest

Development and Human Factors Evaluation of a Portable Auditory Localization Acclimation Training System

Auditory situation awareness (ASA) is essential for safety and survivability in military operations where many of the hazards are not immediately visible. Unfortunately, the Hearing Protection Devices (HPDs) required to operate in these environments can impede auditory localization performance. Promisingly, recent studies have exhibited the plasticity of the human auditory system by demonstrating that training can improve auditory localization ability while wearing HPDs, including military Tactical Communications and Protective Systems (TCAPS). As a result, the U.S. military identified the need for a portable system capable of imparting auditory localization acquisition skills at similar levels to those demonstrated in laboratory environments. The purpose of this investigation was to develop and validate a Portable Auditory Localization Acclimation Training (PALAT) system equipped with an improved training protocol against a proven laboratory grade system referred to as the DRILCOM system and subsequently evaluate the transfer-of-training benefit in a field environment. In Phase I, a systems decision process was used to develop a prototype PALAT system consisting of an expandable frame housing 32-loudspeakers operated by a user-controlled tablet computer capable of reproducing acoustically accurate localization cues similar to the DRILCOM system. Phase II used a within-subjects human factors experiment to validate whether the PALAT system could impart similar auditory localization training benefits as the DRILCOM system. Results showed no significant difference between the two localization training systems at each stage of training or in training rates for the open ear and with two TCAPS devices. The PALAT system also demonstrated the ability to detect differences in localization accuracy between listening conditions in the same manner as the DRILCOM system. Participant ratings indicated no perceived difference in localization training benefit but significantly preferred the PALAT system user interface which was specifically designed to improve usability features to meet requirements of a user operable system. The Phase III investigation evaluated the transfer-of-training benefit imparted by the PALAT system using a broadband stimulus to a field environment using gunshot stimulus. Training under the open ear and in-the-ear TCAPS resulted in significant differences between the trained and untrained groups from in-office pretest to in-field posttest