Brain MR Image Segmentation Based on an Adaptive Combination of Global and Local Fuzzy Energy

This paper presents a novel fuzzy algorithm for segmentation of brain MR images and simultaneous estimation of intensity inhomogeneity. The proposed algorithm defines an objective function including a local fuzzy energy and a global fuzzy energy. Based on the assumption that the local image intensities belonging to each different tissue satisfy Gaussian distributions with different means, we derive the local fuzzy energy by utilizing maximum a posterior probability (MAP) and Bayes rule. The global fuzzy energy is defined by measuring the distance between the original image and the corresponding inhomogeneity-free image. We combine the global fuzzy energy with the local fuzzy energy using an adaptive weight function whose value varies with the local contrast of the image. This combination enables the proposed algorithm to address intensity inhomogeneity and to improve the accuracy of segmentation and its robustness to initialization. Besides, the proposed algorithm incorporates neighborhood spatial information into the membership function to reduce the impact of noise. Experimental results for synthetic and real images validate the desirable performances of the proposed algorithm

Combining global and local information for the segmentation of MR images of the brain

Magnetic resonance imaging can provide high resolution volumetric images of the brain with exceptional soft tissue contrast. These factors allow the complex structure of the brain to be clearly visualised. This has lead to the development of quantitative methods to analyse neuroanatomical structures. In turn, this has promoted the use of computational methods to automate and improve these techniques. This thesis investigates methods to accurately segment MRI images of the brain. The use of global and local image information is considered, where global information includes image intensity distributions, means and variances and local information is based on the relationship between spatially neighbouring voxels. Methods are explored that aim to improve the classification and segmentation of MR images of the brain by combining these elements. Some common artefacts exist in MR brain images that can be seriously detrimental to image analysis methods. Methods to correct for these artifacts are assessed by exploring their effect, first with some well established classification methods and then with methods that combine global information with local information in the form of a Markov random field model. Another characteristic of MR images is the partial volume effect that occurs where signals from different tissues become mixed over the finite volume of a voxel. This effect is demonstrated and quantified using a simulation. Analysis methods that address these issues are tested on simulated and real MR images. They are also applied to study the structure of the temporal lobes in a group of patients with temporal lobe epilepsy. The results emphasise the benefits and limitations of applying these methods to a problem of this nature. The work in this thesis demonstrates the advantages of using global and local information together in the segmentation of MR brain images and proposes a generalised framework that allows this information to be combined in a flexible way

Multimodal image analysis of the human brain

Gedurende de laatste decennia heeft de snelle ontwikkeling van multi-modale en niet-invasieve hersenbeeldvorming technologieën een revolutie teweeg gebracht in de mogelijkheid om de structuur en functionaliteit van de hersens te bestuderen. Er is grote vooruitgang geboekt in het beoordelen van hersenschade door gebruik te maken van Magnetic Reconance Imaging (MRI), terwijl Elektroencefalografie (EEG) beschouwd wordt als de gouden standaard voor diagnose van neurologische afwijkingen. In deze thesis focussen we op de ontwikkeling van nieuwe technieken voor multi-modale beeldanalyse van het menselijke brein, waaronder MRI segmentatie en EEG bronlokalisatie. Hierdoor voegen we theorie en praktijk samen waarbij we focussen op twee medische applicaties: (1) automatische 3D MRI segmentatie van de volwassen hersens en (2) multi-modale EEG-MRI data analyse van de hersens van een pasgeborene met perinatale hersenschade. We besteden veel aandacht aan de verbetering en ontwikkeling van nieuwe methoden voor accurate en ruisrobuuste beeldsegmentatie, dewelke daarna succesvol gebruikt worden voor de segmentatie van hersens in MRI van zowel volwassen als pasgeborenen. Daarenboven ontwikkelden we een geïntegreerd multi-modaal methode voor de EEG bronlokalisatie in de hersenen van een pasgeborene. Deze lokalisatie wordt gebruikt voor de vergelijkende studie tussen een EEG aanval bij pasgeborenen en acute perinatale hersenletsels zichtbaar in MRI

Simultaneous MAP estimation of inhomogeneity and segmentation of brain tissues from MR images

Intrascan and interscan intensity inhomogeneities have been identified as a common source of making many advanced segmentation techniques fail to produce satisfactory results in separating brains tissues from multi-spectral magnetic resonance (MR) images. A common solution is to correct the inhomogeneity before applying the segmentation techniques. This paper presents a method that is able to achieve simultaneous semi-supervised MAP (maximum a-posterior probability) estimation of the inhomogeneity field and segmentation of brain tissues, where the inhomogeneity is parameterized. Our method can incorporate any available incomplete training data and their contribution can be controlled in a flexible manner and therefore the segmentation of the brain tissues can be optimised. Experiments on both simulated and real MR images have demonstrated that the proposed method estimated the inhomogeneity field accurately and improved the segmentation

An Intelligent Hybrid Optimization with Deep Learning model-based Schizophrenia Identification from Structural MRI

One of the fatal diseases that claim women while they are pregnant or nursing is schizophrenia. Despite several developments and symptoms, it can be challenging to discern between benign and malignant conditions. The main and most popular imaging method to predict Schizophrenia is MR Images. Furthermore, a few earlier models had a definite accuracy when diagnosing the condition. Stable MRI criteria must also be implemented immediately. Compared to other imaging technologies, the MRI imaging method is the simplest, safest, and most common for predicting Schizophrenia. The following factors are mostly involved in the subprocess for the initial MRI image. Before calculating the length between the sample point and the cluster center, the initial cluster center of the sample is identified. Classification is done according to how far the sample point is from the cluster center. The picture is then generated once the new cluster center has been derived using the classification history and verified to match the cluster convergence condition. A grey wolf optimization-based convolutional neural network approach is offered to get beyond the limitations and find schizophrenia, whether its hazardous or not. Many MRI images or datasets are analyzed in a short time, and the results show a more accurate or higher rate of schizophrenia recognition

Modified fuzzy c-means clustering for automatic tongue base tumour extraction from MRI data

Magnetic resonance imaging (MRI) is a widely used imaging modality to extract tumour regions to assist in radiotherapy and surgery planning. Extraction of a tongue base tumour from MRI is challenging due to variability in its shape, size, intensities and fuzzy boundaries. This paper presents a new automatic algorithm that is shown to be able to extract tongue base tumour from gadolinium-enhanced T1-weighted (T1+Gd) MRI slices. In this algorithm, knowledge of tumour location is added to the objective function of standard fuzzy c-means (FCM) to extract the tumour region. Experimental results on 9 real MRI slices demonstrate that there is good agreement between manual and automatic extraction results with dice similarity coefficient (DSC) of 0.77±0.08

FCM Clustering Algorithms for Segmentation of Brain MR Images

The study of brain disorders requires accurate tissue segmentation of magnetic resonance (MR) brain images which is very important for detecting tumors, edema, and necrotic tissues. Segmentation of brain images, especially into three main tissue types: Cerebrospinal Fluid (CSF), Gray Matter (GM), and White Matter (WM), has important role in computer aided neurosurgery and diagnosis. Brain images mostly contain noise, intensity inhomogeneity, and weak boundaries. Therefore, accurate segmentation of brain images is still a challenging area of research. This paper presents a review of fuzzy c-means (FCM) clustering algorithms for the segmentation of brain MR images. The review covers the detailed analysis of FCM based algorithms with intensity inhomogeneity correction and noise robustness. Different methods for the modification of standard fuzzy objective function with updating of membership and cluster centroid are also discussed