Long term integrity for space station power systems

A study was made of the High Temperature Design Codes ASME N47, British R5, and the French RCC-MR Rules. It is concluded that all these codes provide a good basis of design for space application. The new British R5 is the most complete since it deals with the problem of defects. The ASME N47 was subjected longer to practical application and scrutiny. A draft code is introduced, and a proposed draft for high temperature design in which attempts were made to identify gaps and improvements is suggested. The design is limited by creep characteristics. In these circumstances, life is strongly affected by the selected value of the factor of safety. The factor of safety of primary loads adopted in the codes is 1.5. Maybe a lower value of 1.25 is permissible for use in space. Long term creep rupture data for HAYNES 188 is deficient and it is suggested that extrapolation methods be investigated

Nonphotolithographic nanoscale memory density prospects

Technologies are now emerging to construct molecular-scale electronic wires and switches using bottom-up self-assembly. This opens the possibility of constructing nanoscale circuits and memories where active devices are just a few nanometers square and wire pitches may be on the order of ten nanometers. The features can be defined at this scale without using photolithography. The available assembly techniques have relatively high defect rates compared to conventional lithographic integrated circuits and can only produce very regular structures. Nonetheless, with proper memory organization, it is reasonable to expect these technologies to provide memory densities in excess of 10/sup 11/ b/cm/sup 2/ with modest active power requirements under 0.6 W/Tb/s for random read operations

A preliminary design study of a microparticle accelerator final report, 30 jan. - 13 apr. 1964

Design study for 2MV microparticle accelerato

Reliability and fault tolerance in the European ADS project

After an introduction to the theory of reliability, this paper focuses on a description of the linear proton accelerator proposed for the European ADS demonstration project. Design issues are discussed and examples of cases of fault tolerance are given.Comment: 14 pages, contribution to the CAS - CERN Accelerator School: Course on High Power Hadron Machines; 24 May - 2 Jun 2011, Bilbao, Spai

The Anti-Coincidence Detector for the GLAST Large Area Telescope

This paper describes the design, fabrication and testing of the Anti-Coincidence Detector (ACD) for the Gamma-ray Large Area Space Telescope (GLAST) Large Area Telescope (LAT). The ACD is LAT first-level defense against the charged cosmic ray background that outnumbers the gamma rays by 3-5 orders of magnitude. The ACD covers the top and 4 sides of the LAT tracking detector, requiring a total active area of ~8.3 square meters. The ACD detector utilizes plastic scintillator tiles with wave-length shifting fiber readout. In order to suppress self-veto by shower particles at high gamma-ray energies, the ACD is segmented into 89 tiles of different sizes. The overall ACD efficiency for detection of singly charged relativistic particles entering the tracking detector from the top or sides of the LAT exceeds the required 0.9997.Comment: 33 pages, 19 figure

UK Rules For Unfired Pressure Vessels

The present code PD 5500, formerly BS 5500 [1] evolved partly from the well-known BS 1500 [2] in the 1950's and BS 1515 [3] first published in 1965; the latter permitted higher level allowable stresses and more advanced rules. In 1969, following a report from the Committee of Enquiry into the Pressure Vessel Industry, the British Standards Institution brought all the pressure vessel interests together under one general committee in order to rationalise the activity. This became PVE/ and presides over a large committee structure. There are a series of functional sub-committees who deal with specific aspects and a large number of technical committees as well as many additional sub committees and working groups. Most of these meet regularly. The technical committee PVE/1, Pressure Vessels, has overall responsibility for BS 5500. The functional committee PVE/1/15 Design Methods has an overall responsibility relating to 'Design' with particular reference to the design section of BS 5500 (Section 3). The first edition of BS 5500 was issued in 1976. The actual issue was delayed for some time because, in the early 1970's, there was an attempt in Europe to produce an international pressure vessel standard. A draft of the international standard appeared as ISO DIS 2694 [4] in 1973 but it was not generally accepted and the attempt was abandoned in the mid 70's. It was decided to use some of the material from 2694 within BS 5500 so that although the Standard was long delayed it benefited to some extent from the international efforts. Initially, committee PVE/l set out the concept of a "master" pressure vessel standard which could readily be applied to any vessel in either ferrous or non-ferrous materials and for highly specialised application with the minimum of supplementary requirements. The layout of BS 5500 is consistent with this concept and although the Standard has perhaps not fulfilled this high ideal, it has certainly been employed widely in many industries including non pressure vessel type applications. When issued it had a number of distinctive features compared with other pressure codes viz; weld joint factors were removed, the present three categories of construction were introduced, there was a new novel external pressure section, it has a loose leaf format and an annual updating was introduced. Further editions of BS 5500 have been issued every three years since 1982

Mifepristone reduces insulin resistance in patient volunteers with adrenal incidentalomas that secrete low levels of cortisol : a pilot study

Background: Incidental adrenal masses are commonly detected during imaging for other pathologies. 10% of the elderly population has an ‘adrenal incidentaloma’, up to 20% of these show low-grade autonomous cortisol secretion and 60% of patients with autonomous cortisol secretion have insulin resistance. Cortisol excess is known to cause insulin resistance, an independent cardiovascular risk marker, however in patients with adrenal incidentalomas it is unknown whether their insulin resistance is secondary to the excess cortisol and therefore potentially reversible. In a proof of concept study we examined the short-term effects of glucocorticoid receptor (GR) antagonism in patients with an adrenal incidentaloma to determine whether their insulin resistance was reversible. Methodology/Principal Findings: In a prospective open-label pilot study, six individuals with adrenal incidentalomas and autonomous cortisol secretion were treated with mifepristone (a GR antagonist) 200 mg twice daily and studied for 4 weeks on a Clinical Research Facility. Insulin resistance at four weeks was assessed by insulin resistance indices, lnHOMA-IR and lnMatsuda, and AUC insulin during a 2-hour glucose tolerance test. Biochemical evidence of GR blockade was shown in all individuals and across the group there was a significant reduction in insulin resistance: lnHOMA-IR (1.0vs0.6; p = 0.03), lnHOMA-%beta (4.8vs4.3; p = 0.03) and lnMatsuda (1.2vs1.6; p = 0.03). Five out of six individuals showed a reduction in insulin AUC .7237 pmol/l.min, and in two patients this showed a clinically significant cardiovascular benefit (as defined by the Helsinki heart study). Conclusions: Short-term GR antagonism is sufficient to reduce insulin resistance in some individuals with adrenal incidentalomas and mild cortisol excess. Further assessment is required to assess if the responses may be used to stratify therapy as adrenal incidentalomas may be a common remediable cause of increased cardiovascular risk

Trinity: A Unified Treatment of Turbulence, Transport, and Heating in Magnetized Plasmas

To faithfully simulate ITER and other modern fusion devices, one must resolve electron and ion fluctuation scales in a five-dimensional phase space and time. Simultaneously, one must account for the interaction of this turbulence with the slow evolution of the large-scale plasma profiles. Because of the enormous range of scales involved and the high dimensionality of the problem, resolved first-principles global simulations are very challenging using conventional (brute force) techniques. In this thesis, the problem of resolving turbulence is addressed by developing velocity space resolution diagnostics and an adaptive collisionality that allow for the confident simulation of velocity space dynamics using the approximate minimal necessary dissipation. With regard to the wide range of scales, a new approach has been developed in which turbulence calculations from multiple gyrokinetic flux tube simulations are coupled together using transport equations to obtain self-consistent, steady-state background profiles and corresponding turbulent fluxes and heating. This approach is embodied in a new code, Trinity, which is capable of evolving equilibrium profiles for multiple species, including electromagnetic effects and realistic magnetic geometry, at a fraction of the cost of conventional global simulations. Furthermore, an advanced model physical collision operator for gyrokinetics has been derived and implemented, allowing for the study of collisional turbulent heating, which has not been extensively studied. To demonstrate the utility of the coupled flux tube approach, preliminary results from Trinity simulations of the core of an ITER plasma are presented.Comment: 187 pages, 53 figures, Ph.D. thesis in physics at University of Maryland, single-space versio