4,834 research outputs found
A convolutional autoencoder approach for mining features in cellular electron cryo-tomograms and weakly supervised coarse segmentation
Cellular electron cryo-tomography enables the 3D visualization of cellular
organization in the near-native state and at submolecular resolution. However,
the contents of cellular tomograms are often complex, making it difficult to
automatically isolate different in situ cellular components. In this paper, we
propose a convolutional autoencoder-based unsupervised approach to provide a
coarse grouping of 3D small subvolumes extracted from tomograms. We demonstrate
that the autoencoder can be used for efficient and coarse characterization of
features of macromolecular complexes and surfaces, such as membranes. In
addition, the autoencoder can be used to detect non-cellular features related
to sample preparation and data collection, such as carbon edges from the grid
and tomogram boundaries. The autoencoder is also able to detect patterns that
may indicate spatial interactions between cellular components. Furthermore, we
demonstrate that our autoencoder can be used for weakly supervised semantic
segmentation of cellular components, requiring a very small amount of manual
annotation.Comment: Accepted by Journal of Structural Biolog
Somoclu: An Efficient Parallel Library for Self-Organizing Maps
Somoclu is a massively parallel tool for training self-organizing maps on
large data sets written in C++. It builds on OpenMP for multicore execution,
and on MPI for distributing the workload across the nodes in a cluster. It is
also able to boost training by using CUDA if graphics processing units are
available. A sparse kernel is included, which is useful for high-dimensional
but sparse data, such as the vector spaces common in text mining workflows.
Python, R and MATLAB interfaces facilitate interactive use. Apart from fast
execution, memory use is highly optimized, enabling training large emergent
maps even on a single computer.Comment: 26 pages, 9 figures. The code is available at
https://peterwittek.github.io/somoclu
Neural Collaborative Subspace Clustering
We introduce the Neural Collaborative Subspace Clustering, a neural model
that discovers clusters of data points drawn from a union of low-dimensional
subspaces. In contrast to previous attempts, our model runs without the aid of
spectral clustering. This makes our algorithm one of the kinds that can
gracefully scale to large datasets. At its heart, our neural model benefits
from a classifier which determines whether a pair of points lies on the same
subspace or not. Essential to our model is the construction of two affinity
matrices, one from the classifier and the other from a notion of subspace
self-expressiveness, to supervise training in a collaborative scheme. We
thoroughly assess and contrast the performance of our model against various
state-of-the-art clustering algorithms including deep subspace-based ones.Comment: Accepted to ICML 201
Deep Extreme Multi-label Learning
Extreme multi-label learning (XML) or classification has been a practical and
important problem since the boom of big data. The main challenge lies in the
exponential label space which involves possible label sets especially
when the label dimension is huge, e.g., in millions for Wikipedia labels.
This paper is motivated to better explore the label space by originally
establishing an explicit label graph. In the meanwhile, deep learning has been
widely studied and used in various classification problems including
multi-label classification, however it has not been properly introduced to XML,
where the label space can be as large as in millions. In this paper, we propose
a practical deep embedding method for extreme multi-label classification, which
harvests the ideas of non-linear embedding and graph priors-based label space
modeling simultaneously. Extensive experiments on public datasets for XML show
that our method performs competitive against state-of-the-art result
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