23,661 research outputs found
Robust visualization and discrimination of nanoparticles by interferometric imaging
Single-molecule and single-nanoparticle biosensors are a growing frontier in diagnostics. Digital biosensors are those which enumerate all specifically immobilized biomolecules or biological nanoparticles, and thereby achieve limits of detection usually beyond the reach of ensemble measurements. Here we review modern optical techniques for single nanoparticle detection and describe the single-particle interferometric reflectance imaging sensor (SP-IRIS). We present challenges associated with reliably detecting faint nanoparticles with SP-IRIS, and describe image acquisition processes and software modifications to address them. Specifically, we describe a image acquisition processing method for the discrimination and accurate counting of nanoparticles that greatly reduces both the number of false positives and false negatives. These engineering improvements are critical steps in the translation of SP-IRIS towards applications in medical diagnostics.R01 AI096159 - NIAID NIH HHSFirst author draf
Deep Neural Network and Data Augmentation Methodology for off-axis iris segmentation in wearable headsets
A data augmentation methodology is presented and applied to generate a large
dataset of off-axis iris regions and train a low-complexity deep neural
network. Although of low complexity the resulting network achieves a high level
of accuracy in iris region segmentation for challenging off-axis eye-patches.
Interestingly, this network is also shown to achieve high levels of performance
for regular, frontal, segmentation of iris regions, comparing favorably with
state-of-the-art techniques of significantly higher complexity. Due to its
lower complexity, this network is well suited for deployment in embedded
applications such as augmented and mixed reality headsets
Pigment Melanin: Pattern for Iris Recognition
Recognition of iris based on Visible Light (VL) imaging is a difficult
problem because of the light reflection from the cornea. Nonetheless, pigment
melanin provides a rich feature source in VL, unavailable in Near-Infrared
(NIR) imaging. This is due to biological spectroscopy of eumelanin, a chemical
not stimulated in NIR. In this case, a plausible solution to observe such
patterns may be provided by an adaptive procedure using a variational technique
on the image histogram. To describe the patterns, a shape analysis method is
used to derive feature-code for each subject. An important question is how much
the melanin patterns, extracted from VL, are independent of iris texture in
NIR. With this question in mind, the present investigation proposes fusion of
features extracted from NIR and VL to boost the recognition performance. We
have collected our own database (UTIRIS) consisting of both NIR and VL images
of 158 eyes of 79 individuals. This investigation demonstrates that the
proposed algorithm is highly sensitive to the patterns of cromophores and
improves the iris recognition rate.Comment: To be Published on Special Issue on Biometrics, IEEE Transaction on
Instruments and Measurements, Volume 59, Issue number 4, April 201
Infrared face recognition: a comprehensive review of methodologies and databases
Automatic face recognition is an area with immense practical potential which
includes a wide range of commercial and law enforcement applications. Hence it
is unsurprising that it continues to be one of the most active research areas
of computer vision. Even after over three decades of intense research, the
state-of-the-art in face recognition continues to improve, benefitting from
advances in a range of different research fields such as image processing,
pattern recognition, computer graphics, and physiology. Systems based on
visible spectrum images, the most researched face recognition modality, have
reached a significant level of maturity with some practical success. However,
they continue to face challenges in the presence of illumination, pose and
expression changes, as well as facial disguises, all of which can significantly
decrease recognition accuracy. Amongst various approaches which have been
proposed in an attempt to overcome these limitations, the use of infrared (IR)
imaging has emerged as a particularly promising research direction. This paper
presents a comprehensive and timely review of the literature on this subject.
Our key contributions are: (i) a summary of the inherent properties of infrared
imaging which makes this modality promising in the context of face recognition,
(ii) a systematic review of the most influential approaches, with a focus on
emerging common trends as well as key differences between alternative
methodologies, (iii) a description of the main databases of infrared facial
images available to the researcher, and lastly (iv) a discussion of the most
promising avenues for future research.Comment: Pattern Recognition, 2014. arXiv admin note: substantial text overlap
with arXiv:1306.160
The Boston University Photonics Center annual report 2014-2015
This repository item contains an annual report that summarizes activities of the Boston University Photonics Center in the 2014-2015 academic year. The report provides quantitative and descriptive information regarding photonics programs in education, interdisciplinary research, business innovation, and technology development. The Boston University Photonics Center (BUPC) is an interdisciplinary hub for education, research, scholarship, innovation, and technology development associated with practical uses of light.This has been a good year for the Photonics Center. In the following pages, you will see that the center’s faculty received prodigious honors and awards, generated more than 100 notable scholarly publications in the leading journals in our field, and attracted $18.6M in new research grants/contracts. Faculty and staff also expanded their efforts in education and training, and were awarded two new National Science Foundation– sponsored sites for Research Experiences for Undergraduates and for Teachers. As a community, we hosted a compelling series of distinguished invited speakers, and emphasized the theme of Advanced Materials by Design for the 21st Century at our annual symposium. We continued to support the National Photonics Initiative, and are a part of a New York–based consortium that won the competition for a new photonics- themed node in the National Network of Manufacturing Institutes. Highlights of our research achievements for the year include an ambitious new DoD-sponsored grant for Multi-Scale Multi-Disciplinary Modeling of Electronic Materials led by Professor Enrico Bellotti, continued support of our NIH-sponsored Center for Innovation in Point of Care Technologies for the Future of Cancer Care led by Professor Catherine Klapperich, a new award for Personalized Chemotherapy Through Rapid Monitoring with Wearable Optics led by Assistant Professor Darren Roblyer, and a new award from DARPA to conduct research on Calligraphy to Build Tunable Optical Metamaterials led by Professor Dave Bishop. We were also honored to receive an award from the Massachusetts Life Sciences Center to develop a biophotonics laboratory in our Business Innovation Center
The Boston University Photonics Center annual report 2014-2015
This repository item contains an annual report that summarizes activities of the Boston University Photonics Center in the 2014-2015 academic year. The report provides quantitative and descriptive information regarding photonics programs in education, interdisciplinary research, business innovation, and technology development. The Boston University Photonics Center (BUPC) is an interdisciplinary hub for education, research, scholarship, innovation, and technology development associated with practical uses of light.This has been a good year for the Photonics Center. In the following pages, you will see that the center’s faculty received prodigious honors and awards, generated more than 100 notable scholarly publications in the leading journals in our field, and attracted $18.6M in new research grants/contracts. Faculty and staff also expanded their efforts in education and training, and were awarded two new National Science Foundation– sponsored sites for Research Experiences for Undergraduates and for Teachers. As a community, we hosted a compelling series of distinguished invited speakers, and emphasized the theme of Advanced Materials by Design for the 21st Century at our annual symposium. We continued to support the National Photonics Initiative, and are a part of a New York–based consortium that won the competition for a new photonics- themed node in the National Network of Manufacturing Institutes. Highlights of our research achievements for the year include an ambitious new DoD-sponsored grant for Multi-Scale Multi-Disciplinary Modeling of Electronic Materials led by Professor Enrico Bellotti, continued support of our NIH-sponsored Center for Innovation in Point of Care Technologies for the Future of Cancer Care led by Professor Catherine Klapperich, a new award for Personalized Chemotherapy Through Rapid Monitoring with Wearable Optics led by Assistant Professor Darren Roblyer, and a new award from DARPA to conduct research on Calligraphy to Build Tunable Optical Metamaterials led by Professor Dave Bishop. We were also honored to receive an award from the Massachusetts Life Sciences Center to develop a biophotonics laboratory in our Business Innovation Center
Contrast-enhanced ultrasound examination for the assessment of renal perfusion in cats with chronic kidney disease
Background: Contrast-enhanced ultrasound examination (CEUS) is a functional imaging technique allowing noninvasive assessment of tissue perfusion. Studies in humans show that the technique holds great potential to be used in the diagnosis of chronic kidney disease (CKD). However, data in veterinary medicine are currently lacking.
Objectives: To evaluate renal perfusion using CEUS in cats with CKD.
Animals: Fourteen client-owned cats with CKD and 43 healthy control cats.
Methods: Prospective case-controlled clinical trial using CEUS to evaluate renal perfusion in cats with CKD compared to healthy control cats. Time-intensity curves were created, and perfusion parameters were calculated using off-line software. A linear mixed model was used to examine differences between perfusion parameters of cats with CKD and healthy cats.
Results: In cats with CKD, longer time to peak and shorter mean transit times were observed for the renal cortex. In contrast, a shorter time to peak and rise time were seen for the renal medulla. The findings for the renal cortex indicate decreased blood velocity and shorter total duration of enhancement, likely caused by increased vascular resistance in CKD. Increased blood velocity in the renal medulla has not been described before and may be because of a different response to regulatory factors in cortex and medulla.
Conclusions and Clinical Importance: Contrast-enhanced ultrasound examination was capable of detecting perfusion changes in cats with CKD. Further research is warranted to assess the diagnostic capabilities of CEUS in early stage of the disease process
James Webb Space Telescope Optical Simulation Testbed I: Overview and First Results
The James Webb Space Telescope (JWST) Optical Simulation Testbed (JOST) is a
tabletop workbench to study aspects of wavefront sensing and control for a
segmented space telescope, including both commissioning and maintenance
activities. JOST is complementary to existing optomechanical testbeds for JWST
(e.g. the Ball Aerospace Testbed Telescope, TBT) given its compact scale and
flexibility, ease of use, and colocation at the JWST Science & Operations
Center. We have developed an optical design that reproduces the physics of
JWST's three-mirror anastigmat using three aspheric lenses; it provides similar
image quality as JWST (80% Strehl ratio) over a field equivalent to a NIRCam
module, but at HeNe wavelength. A segmented deformable mirror stands in for the
segmented primary mirror and allows control of the 18 segments in piston, tip,
and tilt, while the secondary can be controlled in tip, tilt and x, y, z
position. This will be sufficient to model many commissioning activities, to
investigate field dependence and multiple field point sensing & control, to
evaluate alternate sensing algorithms, and develop contingency plans. Testbed
data will also be usable for cross-checking of the WFS&C Software Subsystem,
and for staff training and development during JWST's five- to ten-year mission.Comment: Proceedings of the SPIE, 9143-150. 13 pages, 8 figure
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