Inventory drivers in a pharmaceutical supply chain

In recent years, inventory reduction has been a key objective of pharmaceutical companies, especially within cost optimization initiatives. Pharmaceutical supply chains are characterized by volatile and unpredictable demands –especially in emergent markets-, high service levels, and complex, perishable finished-good portfolios, which makes keeping reasonable amounts of stock a true challenge. However, a one-way strategy towards zero-inventory is in reality inapplicable, due to the strategic nature and importance of the products being commercialised. Therefore, pharmaceutical supply chains are in need of new inventory strategies in order to remain competitive. Finished-goods inventory management in the pharmaceutical industry is closely related to the manufacturing systems and supply chain configurations that companies adopt. The factors considered in inventory management policies, however, do not always cover the full supply chain spectrum in which companies operate. This paper works under the pre-assumption that, in fact, there is a complex relationship between the inventory configurations that companies adopt and the factors behind them. The intention of this paper is to understand the factors driving high finished-goods inventory levels in pharmaceutical supply chains and assist supply chain managers in determining which of them can be influenced in order to reduce inventories to an optimal degree. Reasons for reducing inventory levels are found in high inventory holding and scrap related costs; in addition to lost sales for not being able to serve the customers with the adequate shelf life requirements. The thesis conducts a single case study research in a multi-national pharmaceutical company, which is used to examine typical inventory configurations and the factors affecting these configurations. This paper presents a framework that can assist supply chain managers in determining the most important inventory drivers in pharmaceutical supply chains. The findings in this study suggest that while external and downstream supply chain factors are recognized as being critical to pursue inventory optimization initiatives, pharmaceutical companies are oriented towards optimizing production processes and meeting regulatory requirements while still complying with high service levels, being internal factors the ones prevailing when making inventory management decisions. Furthermore, this paper investigates, through predictive modelling techniques, how various intrinsic and extrinsic factors influence the inventory configurations of the case study company. The study shows that inventory configurations are relatively unstable over time, especially in configurations that present high safety stock levels; and that production features and product characteristics are important explanatory factors behind high inventory levels. Regulatory requirements also play an important role in explaining the high strategic inventory levels that pharmaceutical companies hold

Inventory routing problem with non-stationary stochastic demands

In this paper we solve Stochastic Periodic Inventory Routing Problem (SPIRP) when the accuracy of expected demand is changing among the periods. The variability of demands increases from period to period. This variability follows a certain rate of uncertainty. The uncertainty rate shows the change in accuracy level of demands during the planning horizon. To deal with the growing uncertainty, we apply a safety stock based SPIRP model with different levels of safety stock. To satisfy the service level in the whole planning horizon, the level of safety stock needs to be adjusted according to the demand's variability. In addition, the behavior of the solution model in long term planning horizons for retailers with different demand accuracy is taken into account. We develop the SPIRP model for one retailer with an average level of demand, and standard deviation for each period. The objective is to find an optimum level of safety stock to be allocated to the retailer, in order to achieve the expected level of service, and minimize the costs. We propose a model to deal with the uncertainty in demands, and evaluate the performance of the model based on the defined indicators and experimentally designed cases

E-logistics of agribusiness organisations

Logistics is one of the most important agribusiness functions due to the idiosyncrasy of food products and the structure of food supply chain. Companies in the food sector typically operate with poor production forecasting, inefficient inventory management, lack of coordination with supply partners. Further, markets are characterised by stern competition, increasing consumer demands and stringent regulation for food quality and safety. Large agribusiness corporations have already turned to e-logistics solutions as a means to sustain competitive advantage and meet consumer demands. There are four types of e-logistics applications: (a) Vertical alliances where supply partners forge long-term strategic alliances based on electronic sharing of critical logistics information such as sales forecasts and inventory volume. Vertical alliances often apply supply chain management (SCM) which is concerned with the relationship between a company and its suppliers and customers. The prime characteristic of SCM is interorganizational coordination: agribusiness companies working jointly with their customers and suppliers to integrate activities along the supply chain to effectively supply food products to customers. E-logistics solutions engender the systematic integration among supply partners by allowing more efficient and automatic information flow. (b) e-tailing, in which retailers give consumers the ability to order food such as groceries from home electronically i.e. using the Internet and the subsequent delivery of those ordered goods at home. (c) Efficient Foodservice Response (EFR), which is a strategy designed to enable foodservice industry to achieve profitable growth by looking at ways to save money for each level of the supply chain by eliminating inefficient practices. EFR provides solutions to common logistics problems, such as transactional inefficiency, inefficient plant scheduling, out-of-stocks, and expedited transportation. (d) Contracting, a means of coordinating procurement of food, beverages and their associated supplies. Many markets and supply chains in agriculture are buyer-driven where the buyers in the market tend to set prices and terms of trade. Those terms can include the use of electronic means of communication to support automatic replenishment of goods, management of supply and inventory. The results of the current applications of e-logistics in food sector are encouraging for Greek agribusiness. Companies need to become aware of and evaluate the value-added by those applications which are a sustainable competitive advantage, optimisation of supply chain flows, and meeting consumer demands and food safety regulations. E-business diffusion has shown that typically first-movers gain a significant competitive advantage and the rest companies either eventually adopt the new systems or see a significant decline in their trading partners and perish. E-logistics solutions typically require huge investments in hardware and software and skilled personnel, which is an overt barrier for most Greek companies. Large companies typically are first-movers but small and medium enterprises (SMEs) need institutional support in order to become aware that e-logistics systems can be fruitful for them as well

Optimizing campaign sizing policies: an application to a real-life setting.

This paper presents an integrated production inventory model that enables to capture the tradeoffs between average inventory, production capacity and customer service level in a semiprocess industry setting. The model includes different features that are specific for such a setting, such as differences in reactor yield and quality requirements across products, the need for cleaning reactors when switching between product types, and the requirement to produce products in campaign sizes that are an integer multiple of the reactor’s batch size. The model can be used to support midterm planning procedures. In this paper, we illustrate the application of the model to real-life data of two product families at a large specialty chemicals company, which for reasons of confidentiality is further referred to as Company C.Queueing; Campaign sizing; (Semi)process industries;

Stochastic multi-period multi-product multi-objective Aggregate Production Planning model in multi-echelon supply chain

In this paper a multi-period multi-product multi-objective aggregate production planning (APP) model is proposed for an uncertain multi-echelon supply chain considering financial risk, customer satisfaction, and human resource training. Three conflictive objective functions and several sets of real constraints are considered concurrently in the proposed APP model. Some parameters of the proposed model are assumed to be uncertain and handled through a two-stage stochastic programming (TSSP) approach. The proposed TSSP is solved using three multi-objective solution procedures, i.e., the goal attainment technique, the modified ε-constraint method, and STEM method. The whole procedure is applied in an automotive resin and oil supply chain as a real case study wherein the efficacy and applicability of the proposed approaches are illustrated in comparison with existing experimental production planning method

Disruption management in passenger railway transportation.

This paper deals with disruption management in passengerrailway transportation. In the disruption management process, manyactors belonging to different organizations play a role. In this paperwe therefore describe the process itself and the roles of thedifferent actors.Furthermore, we discuss the three main subproblems in railwaydisruption management: timetable adjustment, and rolling stock andcrew re-scheduling. Next to a general description of these problems,we give an overview of the existing literature and we present somedetails of the specific situations at DSB S-tog and NS. These arethe railway operators in the suburban area of Copenhagen, Denmark,and on the main railway lines in the Netherlands, respectively.Since not much research has been carried out yet on OperationsResearch models for disruption management in the railway context,models and techniques that have been developed for related problemsin the airline world are discussed as well.Finally, we address the integration of the re-scheduling processesof the timetable, and the resources rolling stock and crew.

Operations research in passenger railway transportation

In this paper, we give an overview of state-of-the-art OperationsResearch models and techniques used in passenger railwaytransportation. For each planning phase (strategic, tactical andoperational), we describe the planning problems arising there anddiscuss some models and algorithms to solve them. We do not onlyconsider classical, well-known topics such as timetabling, rollingstock scheduling and crew scheduling, but we also discuss somerecently developed topics as shunting and reliability oftimetables.Finally, we focus on several practical aspects for each of theseproblems at the largest Dutch railway operator, NS Reizigers.passenger railway transportation;operation research;planning problems

Simulation Based Study of Safety Stocks under Short-Term Demand Volatility in Integrated Device Manufacturing.

© IEOM Society InternationalA problem faced by integrated device manufacturers (IDMs) relates to fluctuating demand and can be reflected in long-term demand, middle-term demand, and short-term demand fluctuations. This paper explores safety stock under short term demand fluctuations in integrated device manufacturing. The manufacturing flow of integrated circuits is conceptualized into front end and back end operations with a die bank in between. Using a model of the back-end operations of integrated circuit manufacturing, simulation experiments were conducted based on three scenarios namely a production environment of low demand volatility and high capacity reliability (Scenario A), an environment with lower capacity reliability than scenario A (Scenario B), and an environment of high demand volatility and low capacity reliability (Scenario C). Results show trade-off relation between inventory levels and delivery performance with varied degree of severity between the different scenarios studied. Generally, higher safety stock levels are required to achieve competitive delivery performance as uncertainty in demand increases and manufacturing capability reliability decreases. Back-end cycle time are also found to have detrimental impact on delivery performance as the cycle time increases. It is suggested that success of finished goods safety stock policy relies significantly on having appropriate capacity amongst others to support fluctuations