Benefits of and barriers to involving users in medical device technology development and evaluation

Objectives: This study investigated the benefits of, and barriers to user involvement in medical device technology development and evaluation. Methods: A structured review of published literature in peer-reviewed journals. Results: This review revealed that the main benefits of user involvement were an increased access to user needs, experiences and ideas; improvements in medical device designs and user interfaces; and an increase in the functionality, usability and quality of the devices. On the other hand, resource issues, particularly those of time and money were found the key impediments to involving users in the development and evaluation of medical device technologies. This study has categorised both the benefits and barriers to user involvement also. Conclusions: The involvement of users in MDTD&E requires resources, which are limited; however, it is essential from both users and manufacturers perspectives

MONITORING OF LANDSLIDES WITH MASS MARKET GPS: AN ALTERNATIVE LOW COST SOLUTION

The territory of Italy is seriously afflicted by hydrological risk, with 82% of its area affected by this phenomenon. In recent years, technologies and advanced research have played an important role in realizing complex automatic systems devoted to landslide monitoring and to alerting the population. Sometimes, the cost of these systems (communications network, sensors, software, technologies) prevents their use, and in particular the cost of sensors has a large impact on the final investment. For example, geodetic GNSS receivers are usually employed to conduct landslide monitoring, but they are costly. Nowadays, new technologies make it possible to use small and efficient low cost single frequency GPS receivers, which are able to achieve a centimetrical or better level of accuracy, in static positioning. The rapid development and diffusion of the GNSS network to provide a positioning service has made it possible to use single frequency receivers, thanks to the use of virtual RINEX. This product is generated by a network of permanent stations. In this research, the actual performance of a mass market GPS receiver was tested, with the purpose of verifying if these sensors can be used for landslide monitoring. A special slide was realized, in order to conduct a dedicated test of the detection of displacements. Tests were carried out considering two factors: acquisition time and distance from the Virtual Station. The accuracy and precision of movement determination were evaluated and compared, for each test, considering the different factors. The tests and results are described in this contributio

Why pitch sensitivity matters : event-related potential evidence of metric and syntactic violation detection among spanish late learners of german

Event-related potential (ERP) data in monolingual German speakers have shown that sentential metric expectancy violations elicit a biphasic ERP pattern consisting of an anterior negativity and a posterior positivity (P600). This pattern is comparable to that elicited by syntactic violations. However, proficient French late learners of German do not detect violations of metric expectancy in German. They also show qualitatively and quantitatively different ERP responses to metric and syntactic violations. We followed up the questions whether (1) latter evidence results from a potential pitch cue insensitivity in speech segmentation in French speakers, or (2) if the result is founded in rhythmic language differences. Therefore, we tested Spanish late learners of German, as Spanish, contrary to French, uses pitch as a segmentation cue even though the basic segmentation unit is the same in French and Spanish (i.e., the syllable). We report ERP responses showing that Spanish L2 learners are sensitive to syntactic as well as metric violations in German sentences independent of attention to task in a P600 response. Overall, the behavioral performance resembles that of German native speakers. The current data suggest that Spanish L2 learners are able to extract metric units (trochee) in their L2 (German) even though their basic segmentation unit in Spanish is the syllable. In addition Spanish in contrast to French L2 learners of German are sensitive to syntactic violations indicating a tight link between syntactic and metric competence. This finding emphasizes the relevant role of metric cues not only in L2 prosodic but also in syntactic processing

Link between mindfulness and personality-related factors including empathy, theory of mind, openness, pro-social behaviour and suggestibility

This research investigated a potential linkage between mindfulness and personality characteristics such as openness to experience, empathy (empathic concern and theory of mind), prosocial behavior and suggestibility. A sample of 275 volunteers was recruited. A series of the research questionnaires and scales was employed to measure mindfulness, empathic concern, theory of mind (or perspective taking), prosocial behavior (or altruism) and suggestibility. Based on the quartile scores, participants were divided into two low (first quartile) and high (forth quartile) on mindfulness. Using a two-way MANOVA, the results showed that participants high on mindfulness exhibited increased theory of mind, prosocial behaviour and openness, in addition to decreased suggestibility. Neither main nor interaction effects were found for gender factor. Theoretical models in the field of social cognition will be discussed to explain how enhancement in cognitive functions due to mindfulness practice might alter personality characteristics and, in turn, influence socio-political behaviour

Characterization of seediness attributes of blackberry genotypes

Fresh market blackberries can feel “seedy” when consumed. This “seediness” is associated with the presence of pyrenes which are comprised of a single seed enclosed in an endocarp. Small pyrene size

The University of New Hampshire Engaged Scholars Academy: Instilling in Faculty Principles of Effective Partnership

Over the last decade, the University of New Hampshire (UNH) has promoted mutually beneficial partnerships between faculty and community partners vis-à-vis the Engaged Scholars Academy (ESA), a faculty development program aimed at enhancing faculty understanding of the principles of partnership and engaged scholarship. This research seeks to determine whether and how the ESA has impacted faculty-community partnerships around engaged scholarship. Findings suggest that Engaged Scholar Academy participants – as compared to non-participants – have a deeper understanding of the principles of partnership, are more likely to feel their scholarship is enhanced, spend more time with partners, engage their partners throughout the process of inquiry, and focus more on sustaining partnership outcomes

Long term effects of mesoglycan on brachial arterial stiffness and MMP-9/TIMP-1 system in patients with metabolic syndrome

Objectives: The aim of this study was to evaluate the chronic effects of mesoglycan on the vascular remodeling in patients with metabolic syndrome (Mets). Background: MetS is defined by a clustering of vascular risk factors that require both pharmacologic and non-pharmacologic interventions, including body weight reductions and physical activity. The correction of vascular remodeling associated with MetS has lately received increasing interest. Methods: Thirty consecutive ambulatory patients affected by MetS were 2:1 randomized in a doubleblind fashion to receive mesoglycan or placebo, respectively. At the beginning and after 90 days of oral treatment we appraised the effects of mesoglycan (50 mg per os bid) or placebo on vascular remodeling, as assessed by the measurement of arterial wall elastic properties. Moreover, the matrix metalloproteinase’s (MMPs) type 9 and tissue inhibitor of metalloproteinase (TIMP) type 1 were analyzed by enzyme-linked immune sorbent assay (ELISA) and gelatin substrate zymography at the beginning of the study and after 90 days of treatment. Results: After 90 days of treatment, a marked improvement of arterial distensibility and compliance was detected in Mesoglycan group, with associated significant reduction of arterial stiffness, and a significant reduction of serum levels of MMP-9 and TIMP-1 and significant reduction of enzyme activity of MMPs. Conclusions: This small, preliminary study shows that mesoglycan exerts relevant effects on vascular remodeling after three-month treatment, in patients affected by metabolic syndrome

Synaptic Wnt/GSK3β Signaling Hub in Autism

Indexación: ScopusHundreds of genes have been associated with autism spectrum disorders (ASDs) and the interaction of weak and de novo variants derive from distinct autistic phenotypes thus making up the "spectrum." The convergence of these variants in networks of genes associated with synaptic function warrants the study of cell signaling pathways involved in the regulation of the synapse. The Wnt/β-catenin signaling pathway plays a central role in the development and regulation of the central nervous system and several genes belonging to the cascade have been genetically associated with ASDs. In the present paper, we review basic information regarding the role of Wnt/β-catenin signaling in excitatory/inhibitory balance (E/I balance) through the regulation of pre-and postsynaptic compartments. Furthermore, we integrate information supporting the role of the glycogen synthase kinase 3β (GSK3β) in the onset/development of ASDs through direct modulation of Wnt/β-catenin signaling. Finally, given GSK3β activity as key modulator of synaptic plasticity, we explore the potential of this kinase as a therapeutic target for ASD.https://www.hindawi.com/journals/np/2016/9603751