Immunity and Simplicity for Exact Counting and Other Counting Classes

Ko [RAIRO 24, 1990] and Bruschi [TCS 102, 1992] showed that in some relativized world, PSPACE (in fact, ParityP) contains a set that is immune to the polynomial hierarchy (PH). In this paper, we study and settle the question of (relativized) separations with immunity for PH and the counting classes PP, C_{=}P, and ParityP in all possible pairwise combinations. Our main result is that there is an oracle A relative to which C_{=}P contains a set that is immune to BPP^{ParityP}. In particular, this C_{=}P^A set is immune to PH^{A} and ParityP^{A}. Strengthening results of Tor\'{a}n [J.ACM 38, 1991] and Green [IPL 37, 1991], we also show that, in suitable relativizations, NP contains a C_{=}P-immune set, and ParityP contains a PP^{PH}-immune set. This implies the existence of a C_{=}P^{B}-simple set for some oracle B, which extends results of Balc\'{a}zar et al. [SIAM J.Comp. 14, 1985; RAIRO 22, 1988] and provides the first example of a simple set in a class not known to be contained in PH. Our proof technique requires a circuit lower bound for ``exact counting'' that is derived from Razborov's [Mat. Zametki 41, 1987] lower bound for majority.Comment: 20 page

On unbalanced Boolean functions with best correlation immunity

It is known that the order of correlation immunity of a nonconstant unbalanced Boolean function in $n$ variables cannot exceed $2n/3-1$; moreover, it is $2n/3-1$ if and only if the function corresponds to an equitable $2$-partition of the $n$-cube with an eigenvalue $-n/3$ of the quotient matrix. The known series of such functions have proportion $1:3$, $3:5$, or $7:9$ of the number of ones and zeros. We prove that if a nonconstant unbalanced Boolean function attains the correlation-immunity bound and has ratio $C:B$ of the number of ones and zeros, then $CB$ is divisible by $3$. In particular, this proves the nonexistence of equitable partitions for an infinite series of putative quotient matrices. We also establish that there are exactly $2$ equivalence classes of the equitable partitions of the $12$-cube with quotient matrix $[[3,9],[7,5]]$ and $16$ classes, with $[[0,12],[4,8]]$. These parameters correspond to the Boolean functions in $12$ variables with correlation immunity $7$ and proportion $7:9$ and $1:3$, respectively (the case $3:5$ remains unsolved). This also implies the characterization of the orthogonal arrays OA$(1024,12,2,7)$ and OA$(512,11,2,6)$.Comment: v3: final; title changed; revised; OA(512,11,2,6) discusse

Computation of epidemic final size distributions

We develop a new methodology for the efficient computation of epidemic final size distributions for a broad class of Markovian models. We exploit a particular representation of the stochastic epidemic process to derive a method which is both computationally efficient and numerically stable. The algorithms we present are also physically transparent and so allow us to extend this method from the basic SIR model to a model with a phase-type infectious period and another with waning immunity. The underlying theory is applicable to many Markovian models where we wish to efficiently calculate hitting probabilities.Comment: final published versio

A Second Step Towards Complexity-Theoretic Analogs of Rice's Theorem

Rice's Theorem states that every nontrivial language property of the recursively enumerable sets is undecidable. Borchert and Stephan initiated the search for complexity-theoretic analogs of Rice's Theorem. In particular, they proved that every nontrivial counting property of circuits is UP-hard, and that a number of closely related problems are SPP-hard. The present paper studies whether their UP-hardness result itself can be improved to SPP-hardness. We show that their UP-hardness result cannot be strengthened to SPP-hardness unless unlikely complexity class containments hold. Nonetheless, we prove that every P-constructibly bi-infinite counting property of circuits is SPP-hard. We also raise their general lower bound from unambiguous nondeterminism to constant-ambiguity nondeterminism.Comment: 14 pages. To appear in Theoretical Computer Scienc

Resource Bounded Immunity and Simplicity

Revisiting the thirty years-old notions of resource-bounded immunity and simplicity, we investigate the structural characteristics of various immunity notions: strong immunity, almost immunity, and hyperimmunity as well as their corresponding simplicity notions. We also study limited immunity and simplicity, called k-immunity and feasible k-immunity, and their simplicity notions. Finally, we propose the k-immune hypothesis as a working hypothesis that guarantees the existence of simple sets in NP.Comment: This is a complete version of the conference paper that appeared in the Proceedings of the 3rd IFIP International Conference on Theoretical Computer Science, Kluwer Academic Publishers, pp.81-95, Toulouse, France, August 23-26, 200

Complexity of certificates, heuristics, and counting types , with applications to cryptography and circuit theory

In dieser Habilitationsschrift werden Struktur und Eigenschaften von Komplexitätsklassen wie P und NP untersucht, vor allem im Hinblick auf: Zertifikatkomplexität, Einwegfunktionen, Heuristiken gegen NP-Vollständigkeit und Zählkomplexität. Zum letzten Punkt werden speziell untersucht: (a) die Komplexität von Zähleigenschaften von Schaltkreisen, (b) Separationen von Zählklassen mit Immunität und (c) die Komplexität des Zählens der Lösungen von ,,tally`` NP-Problemen

Paths to a malaria vaccine illuminated by parasite genomics.

More human death and disease is caused by malaria parasites than by all other eukaryotic pathogens combined. As early as the sequencing of the first human genome, malaria parasite genomics was prioritized to fuel the discovery of vaccine candidate antigens. This stimulated increased research on malaria, generating new understanding of the cellular and molecular mechanisms of infection and immunity. This review of recent developments illustrates how new approaches in parasite genomics, and increasingly large amounts of data from population studies, are helping to identify antigens that are promising lead targets. Although these results have been encouraging, effective discovery and characterization need to be coupled with more innovation and funding to translate findings into newly designed vaccine products for clinical trials