AUTOMATED QUANTITATIVE ASSESSMENT OF CORONARY CALCIFICATION USING INTRAVASCULAR ULTRASOUND

Coronary calcification represents a challenge in the treatment of coronary artery disease by stent placement. It negatively affects stent expansion and has been related to future adverse cardiac events. Intravascular ultrasound (IVUS) is known for its high sensitivity in detecting coronary calcification. At present, automated quantification of calcium as detected by IVUS is not available. For this reason, we developed and validated an optimized framework for accurate automated detection and quantification of calcified plaque in coronary atherosclerosis as seen by IVUS. Calcified lesions were detected by training a supported vector classifier per IVUS A-line on manually annotated IVUS images, followed by post-processing using regional information. We applied our framework to 35 IVUS pullbacks from each of the three commonly used IVUS systems. Cross-validation accuracy for each system was >0.9, and the testing accuracy was 0.87, 0.89 and 0.89 for the three systems. Using the detection result, we propose an IVUS calcium score, based on the fraction of calcium-positive A-lines in a pullback segment, to quantify the extent of calcified plaque. The high accuracy of the proposed classifier suggests that it may provide a robust and accurate tool to assess the presence and amount of coronary calcification and, thus, may play a role in imageguided coronary interventions. (E-mail: [email protected]

Colour based semantic image segmentation and classification for unmanned ground operations

To aid an automatic taxiing system for unmanned aircraft, this paper presents a colour based method for semantic segmentation and image classification in an aerodrome environment with the intention to use the classification output to aid navigation and collision avoidance. Based on previous work, this machine vision system uses semantic segmentation to interpret the scene. Following an initial superpixel based segmentation procedure, a colour based Bayesian Network classifier is trained and used to semantically classify each segmented cluster. HSV colourspace is adopted as it is close to the way of human vision perception of the world, and each channel shows significant differentiation between classes. Luminance is used to identify surface lines on the taxiway, which is then fused with colour classification to give improved classification results. The classification performance of the proposed colour based classifier is tested in a real aerodrome, which demonstrates that the proposed method outperforms a previously developed texture only based method

Recent Trends in Artificial Intelligence-Assisted Coronary Atherosclerotic Plaque Characterization

Coronary artery disease is a major cause of morbidity and mortality worldwide. Its underlying histopathology is the atherosclerotic plaque, which comprises lipid, fibrous and—when chronic—calcium components. Intravascular ultrasound (IVUS) and intravascular optical coherence tomography (IVOCT) performed during invasive coronary angiography are reference standards for characterizing the atherosclerotic plaque. Fine image spatial resolution attainable with contemporary coronary computed tomographic angiography (CCTA) has enabled noninvasive plaque assessment, including identifying features associated with vulnerable plaques known to presage acute coronary events. Manual interpretation of IVUS, IVOCT and CCTA images demands scarce physician expertise and high time cost. This has motivated recent research into and development of artificial intelligence (AI)-assisted methods for image processing, feature extraction, plaque identification and characterization. We performed parallel searches of the medical and technical literature from 1995 to 2021 focusing respectively on human plaque characterization using various imaging modalities and the use of AI-assisted computer aided diagnosis (CAD) to detect and classify atherosclerotic plaques, including their composition and the presence of high-risk features denoting vulnerable plaques. A total of 122 publications were selected for evaluation and the analysis was summarized in terms of data sources, methods—machine versus deep learning—and performance metrics. Trends in AI-assisted plaque characterization are detailed and prospective research challenges discussed. Future directions for the development of accurate and efficient CAD systems to characterize plaque noninvasively using CCTA are proposed.</jats:p

Hierarchical and Spatial Structures for Interpreting Images of Man-made Scenes Using Graphical Models

The task of semantic scene interpretation is to label the regions of an image and their relations into meaningful classes. Such task is a key ingredient to many computer vision applications, including object recognition, 3D reconstruction and robotic perception. It is challenging partially due to the ambiguities inherent to the image data. The images of man-made scenes, e. g. the building facade images, exhibit strong contextual dependencies in the form of the spatial and hierarchical structures. Modelling these structures is central for such interpretation task. Graphical models provide a consistent framework for the statistical modelling. Bayesian networks and random fields are two popular types of the graphical models, which are frequently used for capturing such contextual information. The motivation for our work comes from the belief that we can find a generic formulation for scene interpretation that having both the benefits from random fields and Bayesian networks. It should have clear semantic interpretability. Therefore our key contribution is the development of a generic statistical graphical model for scene interpretation, which seamlessly integrates different types of the image features, and the spatial structural information and the hierarchical structural information defined over the multi-scale image segmentation. It unifies the ideas of existing approaches, e. g. conditional random field (CRF) and Bayesian network (BN), which has a clear statistical interpretation as the maximum a posteriori (MAP) estimate of a multi-class labelling problem. Given the graphical model structure, we derive the probability distribution of the model based on the factorization property implied in the model structure. The statistical model leads to an energy function that can be optimized approximately by either loopy belief propagation or graph cut based move making algorithm. The particular type of the features, the spatial structure, and the hierarchical structure however is not prescribed. In the experiments, we concentrate on terrestrial man-made scenes as a specifically difficult problem. We demonstrate the application of the proposed graphical model on the task of multi-class classification of building facade image regions. The framework for scene interpretation allows for significantly better classification results than the standard classical local classification approach on man-made scenes by incorporating the spatial and hierarchical structures. We investigate the performance of the algorithms on a public dataset to show the relative importance of the information from the spatial structure and the hierarchical structure. As a baseline for the region classification, we use an efficient randomized decision forest classifier. Two specific models are derived from the proposed graphical model, namely the hierarchical CRF and the hierarchical mixed graphical model. We show that these two models produce better classification results than both the baseline region classifier and the flat CRF.Hierarchische und räumliche Strukturen zur Interpretation von Bildern anthropogener Szenen unter Nutzung graphischer Modelle Ziel der semantischen Bildinterpretation ist es, Bildregionen und ihre gegenseitigen Beziehungen zu kennzeichnen und in sinnvolle Klassen einzuteilen. Dies ist eine der Hauptaufgabe in vielen Bereichen des maschinellen Sehens, wie zum Beispiel der Objekterkennung, 3D Rekonstruktion oder der Wahrnehmung von Robotern. Insbesondere Bilder anthropogener Szenen, wie z.B. Fassadenaufnahmen, sind durch starke räumliche und hierarchische Strukturen gekennzeichnet. Diese Strukturen zu modellieren ist zentrale Teil der Interpretation, für deren statistische Modellierung graphische Modelle ein geeignetes konsistentes Werkzeug darstellen. Bayes Netze und Zufallsfelder sind zwei bekannte und häufig genutzte Beispiele für graphische Modelle zur Erfassung kontextabhängiger Informationen. Die Motivation dieser Arbeit liegt in der überzeugung, dass wir eine generische Formulierung der Bildinterpretation mit klarer semantischer Bedeutung finden können, die die Vorteile von Bayes Netzen und Zufallsfeldern verbindet. Der Hauptbeitrag der vorliegenden Arbeit liegt daher in der Entwicklung eines generischen statistischen graphischen Modells zur Bildinterpretation, welches unterschiedlichste Typen von Bildmerkmalen und die räumlichen sowie hierarchischen Strukturinformationen über eine multiskalen Bildsegmentierung integriert. Das Modell vereinheitlicht die existierender Arbeiten zugrunde liegenden Ideen, wie bedingter Zufallsfelder (conditional random field (CRF)) und Bayesnetze (Bayesian network (BN)). Dieses Modell hat eine klare statistische Interpretation als Maximum a posteriori (MAP) Schätzer eines mehrklassen Zuordnungsproblems. Gegeben die Struktur des graphischen Modells und den dadurch definierten Faktorisierungseigenschaften leiten wir die Wahrscheinlichkeitsverteilung des Modells ab. Dies führt zu einer Energiefunktion, die näherungsweise optimiert werden kann. Der jeweilige Typ der Bildmerkmale, die räumliche sowie hierarchische Struktur ist von dieser Formulierung unabhängig. Wir zeigen die Anwendung des vorgeschlagenen graphischen Modells anhand der mehrklassen Zuordnung von Bildregionen in Fassadenaufnahmen. Wir demonstrieren, dass das vorgeschlagene Verfahren zur Bildinterpretation, durch die Berücksichtigung räumlicher sowie hierarchischer Strukturen, signifikant bessere Klassifikationsergebnisse zeigt, als klassische lokale Klassifikationsverfahren. Die Leistungsfähigkeit des vorgeschlagenen Verfahrens wird anhand eines öffentlich verfügbarer Datensatzes evaluiert. Zur Klassifikation der Bildregionen nutzen wir ein Verfahren basierend auf einem effizienten Random Forest Klassifikator. Aus dem vorgeschlagenen allgemeinen graphischen Modell werden konkret zwei spezielle Modelle abgeleitet, ein hierarchisches bedingtes Zufallsfeld (hierarchical CRF) sowie ein hierarchisches gemischtes graphisches Modell. Wir zeigen, dass beide Modelle bessere Klassifikationsergebnisse erzeugen als die zugrunde liegenden lokalen Klassifikatoren oder die einfachen bedingten Zufallsfelder

Machine vision for UAS ground operations: using semantic segmentation with a bayesian network classifier

This paper discusses the machine vision element of a system designed to allow Unmanned Aerial System (UAS) to perform automated taxiing around civil aerodromes, with only a monocular camera. The purpose of the computer vision system is to provide direct sensor data which can be used to validate vehicle position, in addition to detecting potential collision risks. In practice, untrained clustering is used to segment the visual feed before descriptors of each cluster (primarily colour and texture) are used to estimate the class. As the competency of each individual estimate can vary dependent on multiple factors (number of pixels, lighting conditions and even surface type). A Bayesian network is used to perform probabilistic data fusion, in order to improve the classification results. This result is shown to perform accurate image segmentation in real-world conditions, providing information viable for localisation and obstacle detection

Combinatorial optimisation for arterial image segmentation.

Cardiovascular disease is one of the leading causes of the mortality in the western world. Many imaging modalities have been used to diagnose cardiovascular diseases. However, each has different forms of noise and artifacts that make the medical image analysis field important and challenging. This thesis is concerned with developing fully automatic segmentation methods for cross-sectional coronary arterial imaging in particular, intra-vascular ultrasound and optical coherence tomography, by incorporating prior and tracking information without any user intervention, to effectively overcome various image artifacts and occlusions. Combinatorial optimisation methods are proposed to solve the segmentation problem in polynomial time. A node-weighted directed graph is constructed so that the vessel border delineation is considered as computing a minimum closed set. A set of complementary edge and texture features is extracted. Single and double interface segmentation methods are introduced. Novel optimisation of the boundary energy function is proposed based on a supervised classification method. Shape prior model is incorporated into the segmentation framework based on global and local information through the energy function design and graph construction. A combination of cross-sectional segmentation and longitudinal tracking is proposed using the Kalman filter and the hidden Markov model. The border is parameterised using the radial basis functions. The Kalman filter is used to adapt the inter-frame constraints between every two consecutive frames to obtain coherent temporal segmentation. An HMM-based border tracking method is also proposed in which the emission probability is derived from both the classification-based cost function and the shape prior model. The optimal sequence of the hidden states is computed using the Viterbi algorithm. Both qualitative and quantitative results on thousands of images show superior performance of the proposed methods compared to a number of state-of-the-art segmentation methods

Analysis of contrast-enhanced medical images.

Early detection of human organ diseases is of great importance for the accurate diagnosis and institution of appropriate therapies. This can potentially prevent progression to end-stage disease by detecting precursors that evaluate organ functionality. In addition, it also assists the clinicians for therapy evaluation, tracking diseases progression, and surgery operations. Advances in functional and contrast-enhanced (CE) medical images enabled accurate noninvasive evaluation of organ functionality due to their ability to provide superior anatomical and functional information about the tissue-of-interest. The main objective of this dissertation is to develop a computer-aided diagnostic (CAD) system for analyzing complex data from CE magnetic resonance imaging (MRI). The developed CAD system has been tested in three case studies: (i) early detection of acute renal transplant rejection, (ii) evaluation of myocardial perfusion in patients with ischemic heart disease after heart attack; and (iii), early detection of prostate cancer. However, developing a noninvasive CAD system for the analysis of CE medical images is subject to multiple challenges, including, but are not limited to, image noise and inhomogeneity, nonlinear signal intensity changes of the images over the time course of data acquisition, appearances and shape changes (deformations) of the organ-of-interest during data acquisition, determination of the best features (indexes) that describe the perfusion of a contrast agent (CA) into the tissue. To address these challenges, this dissertation focuses on building new mathematical models and learning techniques that facilitate accurate analysis of CAs perfusion in living organs and include: (i) accurate mathematical models for the segmentation of the object-of-interest, which integrate object shape and appearance features in terms of pixel/voxel-wise image intensities and their spatial interactions; (ii) motion correction techniques that combine both global and local models, which exploit geometric features, rather than image intensities to avoid problems associated with nonlinear intensity variations of the CE images; (iii) fusion of multiple features using the genetic algorithm. The proposed techniques have been integrated into CAD systems that have been tested in, but not limited to, three clinical studies. First, a noninvasive CAD system is proposed for the early and accurate diagnosis of acute renal transplant rejection using dynamic contrast-enhanced MRI (DCE-MRI). Acute rejection–the immunological response of the human immune system to a foreign kidney–is the most sever cause of renal dysfunction among other diagnostic possibilities, including acute tubular necrosis and immune drug toxicity. In the U.S., approximately 17,736 renal transplants are performed annually, and given the limited number of donors, transplanted kidney salvage is an important medical concern. Thus far, biopsy remains the gold standard for the assessment of renal transplant dysfunction, but only as the last resort because of its invasive nature, high cost, and potential morbidity rates. The diagnostic results of the proposed CAD system, based on the analysis of 50 independent in-vivo cases were 96% with a 95% confidence interval. These results clearly demonstrate the promise of the proposed image-based diagnostic CAD system as a supplement to the current technologies, such as nuclear imaging and ultrasonography, to determine the type of kidney dysfunction. Second, a comprehensive CAD system is developed for the characterization of myocardial perfusion and clinical status in heart failure and novel myoregeneration therapy using cardiac first-pass MRI (FP-MRI). Heart failure is considered the most important cause of morbidity and mortality in cardiovascular disease, which affects approximately 6 million U.S. patients annually. Ischemic heart disease is considered the most common underlying cause of heart failure. Therefore, the detection of the heart failure in its earliest forms is essential to prevent its relentless progression to premature death. While current medical studies focus on detecting pathological tissue and assessing contractile function of the diseased heart, this dissertation address the key issue of the effects of the myoregeneration therapy on the associated blood nutrient supply. Quantitative and qualitative assessment in a cohort of 24 perfusion data sets demonstrated the ability of the proposed framework to reveal regional perfusion improvements with therapy, and transmural perfusion differences across the myocardial wall; thus, it can aid in follow-up on treatment for patients undergoing the myoregeneration therapy. Finally, an image-based CAD system for early detection of prostate cancer using DCE-MRI is introduced. Prostate cancer is the most frequently diagnosed malignancy among men and remains the second leading cause of cancer-related death in the USA with more than 238,000 new cases and a mortality rate of about 30,000 in 2013. Therefore, early diagnosis of prostate cancer can improve the effectiveness of treatment and increase the patient’s chance of survival. Currently, needle biopsy is the gold standard for the diagnosis of prostate cancer. However, it is an invasive procedure with high costs and potential morbidity rates. Additionally, it has a higher possibility of producing false positive diagnosis due to relatively small needle biopsy samples. Application of the proposed CAD yield promising results in a cohort of 30 patients that would, in the near future, represent a supplement of the current technologies to determine prostate cancer type. The developed techniques have been compared to the state-of-the-art methods and demonstrated higher accuracy as shown in this dissertation. The proposed models (higher-order spatial interaction models, shape models, motion correction models, and perfusion analysis models) can be used in many of today’s CAD applications for early detection of a variety of diseases and medical conditions, and are expected to notably amplify the accuracy of CAD decisions based on the automated analysis of CE images