Analysis of parametric biological models with non-linear dynamics

In this paper we present recent results on parametric analysis of biological models. The underlying method is based on the algorithms for computing trajectory sets of hybrid systems with polynomial dynamics. The method is then applied to two case studies of biological systems: one is a cardiac cell model for studying the conditions for cardiac abnormalities, and the second is a model of insect nest-site choice.Comment: In Proceedings HSB 2012, arXiv:1208.315

Sapo: Reachability Computation and Parameter Synthesis of Polynomial Dynamical Systems

Sapo is a C++ tool for the formal analysis of polynomial dynamical systems. Its main features are: 1) Reachability computation, i.e., the calculation of the set of states reachable from a set of initial conditions, and 2) Parameter synthesis, i.e., the refinement of a set of parameters so that the system satisfies a given specification. Sapo can represent reachable sets as unions of boxes, parallelotopes, or parallelotope bundles (symbolic representation of polytopes). Sets of parameters are represented with polytopes while specifications are formalized as Signal Temporal Logic (STL) formulas

Algorithmic Verification of Continuous and Hybrid Systems

We provide a tutorial introduction to reachability computation, a class of computational techniques that exports verification technology toward continuous and hybrid systems. For open under-determined systems, this technique can sometimes replace an infinite number of simulations.Comment: In Proceedings INFINITY 2013, arXiv:1402.661

Reachability computation for polynomial dynamical systems

This paper is concerned with the problem of computing the bounded time reachable set of a polynomial discrete-time dynamical system. The problem is well-known for being difficult when nonlinear systems are considered. In this regard, we propose three reachability methods that differ in the set representation. The proposed algorithms adopt boxes, parallelotopes, and parallelotope bundles to construct flowpipes that contain the actual reachable sets. The latter is a new data structure for the symbolic representation of polytopes. Our methods exploit the Bernstein expansion of polynomials to bound the images of sets. The scalability and precision of the presented methods are analyzed on a number of dynamical systems, in comparison with other existing approaches

Analysis of Nonlinear Systems via Bernstein Expansions

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106482/1/AIAA2013-4557.pd

Efficient computation of highly oscillatory integrals by using QTT tensor approximation

We propose a new method for the efficient approximation of a class of highly oscillatory weighted integrals where the oscillatory function depends on the frequency parameter $\omega \geq 0$, typically varying in a large interval. Our approach is based, for fixed but arbitrary oscillator, on the pre-computation and low-parametric approximation of certain $\omega$-dependent prototype functions whose evaluation leads in a straightforward way to recover the target integral. The difficulty that arises is that these prototype functions consist of oscillatory integrals and are itself oscillatory which makes them both difficult to evaluate and to approximate. Here we use the quantized-tensor train (QTT) approximation method for functional $m$-vectors of logarithmic complexity in $m$ in combination with a cross-approximation scheme for TT tensors. This allows the accurate approximation and efficient storage of these functions in the wide range of grid and frequency parameters. Numerical examples illustrate the efficiency of the QTT-based numerical integration scheme on various examples in one and several spatial dimensions.Comment: 20 page

High-order adaptive methods for computing invariant manifolds of maps

The author presents efficient and accurate numerical methods for computing invariant manifolds of maps which arise in the study of dynamical systems. In order to decrease the number of points needed to compute a given curve/surface, he proposes using higher-order interpolation/approximation techniques from geometric modeling. He uses B´ezier curves/triangles, fundamental objects in curve/surface design, to create adaptive methods. The methods are based on tolerance conditions derived from properties of B´ezier curves/triangles. The author develops and tests the methods for an ordinary parametric curve; then he adapts these methods to invariant manifolds of planar maps. Next, he develops and tests the method for parametric surfaces and then he adapts this method to invariant manifolds of three-dimensional maps