Delay-induced patterns in a two-dimensional lattice of coupled oscillators

We show how a variety of stable spatio-temporal periodic patterns can be created in 2D-lattices of coupled oscillators with non-homogeneous coupling delays. A "hybrid dispersion relation" is introduced, which allows studying the stability of time-periodic patterns analytically in the limit of large delay. The results are illustrated using the FitzHugh-Nagumo coupled neurons as well as coupled limit cycle (Stuart-Landau) oscillators

Stability and Hopf bifurcation of controlled complex networks model with two delays

none3siopenJinde Cao, Luca Guerrini, Zunshui ChengCao, Jinde; Guerrini, Luca; Cheng, Zunshu

Time-delayed models of gene regulatory networks

We discuss different mathematical models of gene regulatory networks as relevant to the onset and development of cancer. After discussion of alternativemodelling approaches, we use a paradigmatic two-gene network to focus on the role played by time delays in the dynamics of gene regulatory networks. We contrast the dynamics of the reduced model arising in the limit of fast mRNA dynamics with that of the full model. The review concludes with the discussion of some open problems

Amplitude Death: The emergence of stationarity in coupled nonlinear systems

When nonlinear dynamical systems are coupled, depending on the intrinsic dynamics and the manner in which the coupling is organized, a host of novel phenomena can arise. In this context, an important emergent phenomenon is the complete suppression of oscillations, formally termed amplitude death (AD). Oscillations of the entire system cease as a consequence of the interaction, leading to stationary behavior. The fixed points that the coupling stabilizes can be the otherwise unstable fixed points of the uncoupled system or can correspond to novel stationary points. Such behaviour is of relevance in areas ranging from laser physics to the dynamics of biological systems. In this review we discuss the characteristics of the different coupling strategies and scenarios that lead to AD in a variety of different situations, and draw attention to several open issues and challenging problems for further study.Comment: Physics Reports (2012

The Dynamics of Hybrid Metabolic-Genetic Oscillators

The synthetic construction of intracellular circuits is frequently hindered by a poor knowledge of appropriate kinetics and precise rate parameters. Here, we use generalized modeling (GM) to study the dynamical behavior of topological models of a family of hybrid metabolic-genetic circuits known as "metabolators." Under mild assumptions on the kinetics, we use GM to analytically prove that all explicit kinetic models which are topologically analogous to one such circuit, the "core metabolator," cannot undergo Hopf bifurcations. Then, we examine more detailed models of the metabolator. Inspired by the experimental observation of a Hopf bifurcation in a synthetically constructed circuit related to the core metabolator, we apply GM to identify the critical components of the synthetically constructed metabolator which must be reintroduced in order to recover the Hopf bifurcation. Next, we study the dynamics of a re-wired version of the core metabolator, dubbed the "reverse" metabolator, and show that it exhibits a substantially richer set of dynamical behaviors, including both local and global oscillations. Prompted by the observation of relaxation oscillations in the reverse metabolator, we study the role that a separation of genetic and metabolic time scales may play in its dynamics, and find that widely separated time scales promote stability in the circuit. Our results illustrate a generic pipeline for vetting the potential success of a potential circuit design, simply by studying the dynamics of the corresponding generalized model

Comparative exploration on bifurcation behavior for integer-order and fractional-order delayed BAM neural networks

In the present study, we deal with the stability and the onset of Hopf bifurcation of two type delayed BAM neural networks (integer-order case and fractional-order case). By virtue of the characteristic equation of the integer-order delayed BAM neural networks and regarding time delay as critical parameter, a novel delay-independent condition ensuring the stability and the onset of Hopf bifurcation for the involved integer-order delayed BAM neural networks is built. Taking advantage of Laplace transform, stability theory and Hopf bifurcation knowledge of fractional-order differential equations, a novel delay-independent criterion to maintain the stability and the appearance of Hopf bifurcation for the addressed fractional-order BAM neural networks is established. The investigation indicates the important role of time delay in controlling the stability and Hopf bifurcation of the both type delayed BAM neural networks. By adjusting the value of time delay, we can effectively amplify the stability region and postpone the time of onset of Hopf bifurcation for the fractional-order BAM neural networks. Matlab simulation results are clearly presented to sustain the correctness of analytical results. The derived fruits of this study provide an important theoretical basis in regulating networks

The complexity of dynamics in small neural circuits

Mean-field theory is a powerful tool for studying large neural networks. However, when the system is composed of a few neurons, macroscopic differences between the mean-field approximation and the real behavior of the network can arise. Here we introduce a study of the dynamics of a small firing-rate network with excitatory and inhibitory populations, in terms of local and global bifurcations of the neural activity. Our approach is analytically tractable in many respects, and sheds new light on the finite-size effects of the system. In particular, we focus on the formation of multiple branching solutions of the neural equations through spontaneous symmetry-breaking, since this phenomenon increases considerably the complexity of the dynamical behavior of the network. For these reasons, branching points may reveal important mechanisms through which neurons interact and process information, which are not accounted for by the mean-field approximation.Comment: 34 pages, 11 figures. Supplementary materials added, colors of figures 8 and 9 fixed, results unchange