Application of a single-objective, hybrid genetic algorithm approach to pharmacokinetic model building.

A limitation in traditional stepwise population pharmacokinetic model building is the difficulty in handling interactions between model components. To address this issue, a method was previously introduced which couples NONMEM parameter estimation and model fitness evaluation to a single-objective, hybrid genetic algorithm for global optimization of the model structure. In this study, the generalizability of this approach for pharmacokinetic model building is evaluated by comparing (1) correct and spurious covariate relationships in a simulated dataset resulting from automated stepwise covariate modeling, Lasso methods, and single-objective hybrid genetic algorithm approaches to covariate identification and (2) information criteria values, model structures, convergence, and model parameter values resulting from manual stepwise versus single-objective, hybrid genetic algorithm approaches to model building for seven compounds. Both manual stepwise and single-objective, hybrid genetic algorithm approaches to model building were applied, blinded to the results of the other approach, for selection of the compartment structure as well as inclusion and model form of inter-individual and inter-occasion variability, residual error, and covariates from a common set of model options. For the simulated dataset, stepwise covariate modeling identified three of four true covariates and two spurious covariates; Lasso identified two of four true and 0 spurious covariates; and the single-objective, hybrid genetic algorithm identified three of four true covariates and one spurious covariate. For the clinical datasets, the Akaike information criterion was a median of 22.3 points lower (range of 470.5 point decrease to 0.1 point decrease) for the best single-objective hybrid genetic-algorithm candidate model versus the final manual stepwise model: the Akaike information criterion was lower by greater than 10 points for four compounds and differed by less than 10 points for three compounds. The root mean squared error and absolute mean prediction error of the best single-objective hybrid genetic algorithm candidates were a median of 0.2 points higher (range of 38.9 point decrease to 27.3 point increase) and 0.02 points lower (range of 0.98 point decrease to 0.74 point increase), respectively, than that of the final stepwise models. In addition, the best single-objective, hybrid genetic algorithm candidate models had successful convergence and covariance steps for each compound, used the same compartment structure as the manual stepwise approach for 6 of 7 (86 %) compounds, and identified 54 % (7 of 13) of covariates included by the manual stepwise approach and 16 covariate relationships not included by manual stepwise models. The model parameter values between the final manual stepwise and best single-objective, hybrid genetic algorithm models differed by a median of 26.7 % (q₁ = 4.9 % and q₃ = 57.1 %). Finally, the single-objective, hybrid genetic algorithm approach was able to identify models capable of estimating absorption rate parameters for four compounds that the manual stepwise approach did not identify. The single-objective, hybrid genetic algorithm represents a general pharmacokinetic model building methodology whose ability to rapidly search the feasible solution space leads to nearly equivalent or superior model fits to pharmacokinetic data

Multi-agricultural Machinery Collaborative Task Assignment Based on Improved Genetic Hybrid Optimization Algorithm

To address the challenges of delayed scheduling information, heavy reliance on manual labour, and low operational efficiency in traditional large-scale agricultural machinery operations, this study proposes a method for multi-agricultural machinery collaborative task assignment based on an improved genetic hybrid optimisation algorithm. The proposed method establishes a multi-agricultural machinery task allocation model by combining the path pre-planning of a simulated annealing algorithm and the static task allocation of a genetic algorithm. By sequentially fusing these two algorithms, their respective shortcomings can be overcome, and their advantages in global and local search can be utilised. Consequently, the search capability of the population is enhanced, leading to the discovery of more optimal solutions. Then, an adaptive crossover operator is constructed according to the task assignment model, considering the capacity, path cost, and time of agricultural machinery; two-segment coding and multi-population adaptive mutation are used to assign tasks to improve the diversity of the population and enhance the exploration ability of the population; and to improve the global optimisation ability of the hybrid algorithm, a 2-Opt local optimisation operator and an Circle modification algorithm are introduced. Finally, simulation experiments were conducted in MATLAB to evaluate the performance of the multi-agricultural machinery collaborative task assignment based on the improved genetic hybrid algorithm. The algorithm's capabilities were assessed through comparative analysis in the simulation trials. The results demonstrate that the developed hybrid algorithm can effectively reduce path costs, and the efficiency of the assignment outcomes surpasses that of the classical genetic algorithm. This approach proves particularly suitable for addressing large-scale task allocation problems

Sizing optimization of hybrid photovoltaic-wind-battery system towards zero energy building using genetic algorithm

A new topic of Zero Energy Building is getting famous in research area because of its goal of reaching zero carbon emission and low building cost. Renewable energy system is one of the ideas to achieve the objective of Zero Energy Building. Recently, Genetic Algorithm is widely used in many research area due to its capability to escape from a local minimal to obtain a better solution. In our study, Genetic Algorithm is chosen in sizing optimization of the number of photovoltaic, wind turbine and battery of a hybrid photovoltaic-wind-battery system. Besides, these numbers are used to minimize the total annual cost of the hybrid energy system towards the concept of Zero Energy Building. There are a few Genetic Algorithm parameters that need to be considered in the optimization process which is generation number, population size, crossover operator and mutation operator. Therefore, two Genetic Algorithm parameters will be analysed and optimized which is generation number and population size. All of the simulations are done by using Microsoft Visual Studio 2010. From the results of simulations, the best generation number and population size is 100 000 and 3 000 respectively. In summary, Genetic Algorithm is efficient in minimizing cost function of a hybrid photovoltaic-wind-battery system with its robustness property

Genetic algorithms with memory- and elitism-based immigrants in dynamic environments

Copyright @ 2008 by the Massachusetts Institute of TechnologyIn recent years the genetic algorithm community has shown a growing interest in studying dynamic optimization problems. Several approaches have been devised. The random immigrants and memory schemes are two major ones. The random immigrants scheme addresses dynamic environments by maintaining the population diversity while the memory scheme aims to adapt genetic algorithms quickly to new environments by reusing historical information. This paper investigates a hybrid memory and random immigrants scheme, called memory-based immigrants, and a hybrid elitism and random immigrants scheme, called elitism-based immigrants, for genetic algorithms in dynamic environments. In these schemes, the best individual from memory or the elite from the previous generation is retrieved as the base to create immigrants into the population by mutation. This way, not only can diversity be maintained but it is done more efficiently to adapt genetic algorithms to the current environment. Based on a series of systematically constructed dynamic problems, experiments are carried out to compare genetic algorithms with the memory-based and elitism-based immigrants schemes against genetic algorithms with traditional memory and random immigrants schemes and a hybrid memory and multi-population scheme. The sensitivity analysis regarding some key parameters is also carried out. Experimental results show that the memory-based and elitism-based immigrants schemes efficiently improve the performance of genetic algorithms in dynamic environments.This work was supported by the Engineering and Physical Sciences Research Council (EPSRC) of the United Kingdom under Grant EP/E060722/01

A hybrid genetic algorithm and inver over approach for the travelling salesman problem

This article posted here with permission of the IEEE - Copyright @ 2010 IEEEThis paper proposes a two-phase hybrid approach for the travelling salesman problem (TSP). The first phase is based on a sequence based genetic algorithm (SBGA) with an embedded local search scheme. Within the SBGA, a memory is introduced to store good sequences (sub-tours) extracted from previous good solutions and the stored sequences are used to guide the generation of offspring via local search during the evolution of the population. Additionally, we also apply some techniques to adapt the key parameters based on whether the best individual of the population improves or not and maintain the diversity. After SBGA finishes, the hybrid approach enters the second phase, where the inver over (IO) operator, which is a state-of-the-art algorithm for the TSP, is used to further improve the solution quality of the population. Experiments are carried out to investigate the performance of the proposed hybrid approach in comparison with several relevant algorithms on a set of benchmark TSP instances. The experimental results show that the proposed hybrid approach is efficient in finding good quality solutions for the test TSPs.This work was supported by the Engineering and Physical Sciences Research Council (EPSRC) of the United Kingdom under Grant EP/E060722/1

A hybrid genetic algorithm and tabu search approach for post enrolment course timetabling

Copyright @ Springer Science + Business Media. All rights reserved.The post enrolment course timetabling problem (PECTP) is one type of university course timetabling problems, in which a set of events has to be scheduled in time slots and located in suitable rooms according to the student enrolment data. The PECTP is an NP-hard combinatorial optimisation problem and hence is very difficult to solve to optimality. This paper proposes a hybrid approach to solve the PECTP in two phases. In the first phase, a guided search genetic algorithm is applied to solve the PECTP. This guided search genetic algorithm, integrates a guided search strategy and some local search techniques, where the guided search strategy uses a data structure that stores useful information extracted from previous good individuals to guide the generation of offspring into the population and the local search techniques are used to improve the quality of individuals. In the second phase, a tabu search heuristic is further used on the best solution obtained by the first phase to improve the optimality of the solution if possible. The proposed hybrid approach is tested on a set of benchmark PECTPs taken from the international timetabling competition in comparison with a set of state-of-the-art methods from the literature. The experimental results show that the proposed hybrid approach is able to produce promising results for the test PECTPs.This work was supported by the Engineering and Physical Sciences Research Council (EPSRC) of UK under Grant EP/E060722/01 and Grant EP/E060722/02

The Vehicle Routing Problem with Service Level Constraints

We consider a vehicle routing problem which seeks to minimize cost subject to service level constraints on several groups of deliveries. This problem captures some essential challenges faced by a logistics provider which operates transportation services for a limited number of partners and should respect contractual obligations on service levels. The problem also generalizes several important classes of vehicle routing problems with profits. To solve it, we propose a compact mathematical formulation, a branch-and-price algorithm, and a hybrid genetic algorithm with population management, which relies on problem-tailored solution representation, crossover and local search operators, as well as an adaptive penalization mechanism establishing a good balance between service levels and costs. Our computational experiments show that the proposed heuristic returns very high-quality solutions for this difficult problem, matches all optimal solutions found for small and medium-scale benchmark instances, and improves upon existing algorithms for two important special cases: the vehicle routing problem with private fleet and common carrier, and the capacitated profitable tour problem. The branch-and-price algorithm also produces new optimal solutions for all three problems

3D Protein structure prediction with genetic tabu search algorithm

Abstract Background Protein structure prediction (PSP) has important applications in different fields, such as drug design, disease prediction, and so on. In protein structure prediction, there are two important issues. The first one is the design of the structure model and the second one is the design of the optimization technology. Because of the complexity of the realistic protein structure, the structure model adopted in this paper is a simplified model, which is called off-lattice AB model. After the structure model is assumed, optimization technology is needed for searching the best conformation of a protein sequence based on the assumed structure model. However, PSP is an NP-hard problem even if the simplest model is assumed. Thus, many algorithms have been developed to solve the global optimization problem. In this paper, a hybrid algorithm, which combines genetic algorithm (GA) and tabu search (TS) algorithm, is developed to complete this task. Results In order to develop an efficient optimization algorithm, several improved strategies are developed for the proposed genetic tabu search algorithm. The combined use of these strategies can improve the efficiency of the algorithm. In these strategies, tabu search introduced into the crossover and mutation operators can improve the local search capability, the adoption of variable population size strategy can maintain the diversity of the population, and the ranking selection strategy can improve the possibility of an individual with low energy value entering into next generation. Experiments are performed with Fibonacci sequences and real protein sequences. Experimental results show that the lowest energy obtained by the proposed GATS algorithm is lower than that obtained by previous methods. Conclusions The hybrid algorithm has the advantages from both genetic algorithm and tabu search algorithm. It makes use of the advantage of multiple search points in genetic algorithm, and can overcome poor hill-climbing capability in the conventional genetic algorithm by using the flexible memory functions of TS. Compared with some previous algorithms, GATS algorithm has better performance in global optimization and can predict 3D protein structure more effectively