Human brain evolution and the "Neuroevolutionary Time-depth Principle:" Implications for the Reclassification of fear-circuitry-related traits in DSM-V and for studying resilience to warzone-related posttraumatic stress disorder.

The DSM-III, DSM-IV, DSM-IV-TR and ICD-10 have judiciously minimized discussion of etiologies to distance clinical psychiatry from Freudian psychoanalysis. With this goal mostly achieved, discussion of etiological factors should be reintroduced into the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V). A research agenda for the DSM-V advocated the "development of a pathophysiologically based classification system". The author critically reviews the neuroevolutionary literature on stress-induced and fear circuitry disorders and related amygdala-driven, species-atypical fear behaviors of clinical severity in adult humans. Over 30 empirically testable/falsifiable predictions are presented. It is noted that in DSM-IV-TR and ICD-10, the classification of stress and fear circuitry disorders is neither mode-of-acquisition-based nor brain-evolution-based. For example, snake phobia (innate) and dog phobia (overconsolidational) are clustered together. Similarly, research on blood-injection-injury-type-specific phobia clusters two fears different in their innateness: 1) an arguably ontogenetic memory-trace-overconsolidation-based fear (hospital phobia) and 2) a hardwired (innate) fear of the sight of one's blood or a sharp object penetrating one's skin. Genetic architecture-charting of fear-circuitry-related traits has been challenging. Various, non-phenotype-based architectures can serve as targets for research. In this article, the author will propose one such alternative genetic architecture. This article was inspired by the following: A) Nesse's "Smoke-Detector Principle", B) the increasing suspicion that the "smooth" rather than "lumpy" distribution of complex psychiatric phenotypes (including fear-circuitry disorders) may in some cases be accounted for by oligogenic (and not necessarily polygenic) transmission, and C) insights from the initial sequence of the chimpanzee genome and comparison with the human genome by the Chimpanzee Sequencing and Analysis Consortium published in late 2005. Neuroevolutionary insights relevant to fear circuitry symptoms that primarily emerge overconsolidationally (especially Combat related Posttraumatic Stress Disorder) are presented. Also introduced is a human-evolution-based principle for clustering innate fear traits. The "Neuroevolutionary Time-depth Principle" of innate fears proposed in this article may be useful in the development of a neuroevolution-based taxonomic re-clustering of stress-triggered and fear-circuitry disorders in DSM-V. Four broad clusters of evolved fear circuits are proposed based on their time-depths: 1) Mesozoic (mammalian-wide) circuits hardwired by wild-type alleles driven to fixation by Mesozoic selective sweeps; 2) Cenozoic (simian-wide) circuits relevant to many specific phobias; 3) mid Paleolithic and upper Paleolithic (Homo sapiens-specific) circuits (arguably resulting mostly from mate-choice-driven stabilizing selection); 4) Neolithic circuits (arguably mostly related to stabilizing selection driven by gene-culture co-evolution). More importantly, the author presents evolutionary perspectives on warzone-related PTSD, Combat-Stress Reaction, Combat-related Stress, Operational-Stress, and other deployment-stress-induced symptoms. The Neuroevolutionary Time-depth Principle presented in this article may help explain the dissimilar stress-resilience levels following different types of acute threat to survival of oneself or one's progency (aka DSM-III and DSM-V PTSD Criterion-A events). PTSD rates following exposure to lethal inter-group violence (combat, warzone exposure or intentionally caused disasters such as terrorism) are usually 5-10 times higher than rates following large-scale natural disasters such as forest fires, floods, hurricanes, volcanic eruptions, and earthquakes. The author predicts that both intentionally-caused large-scale bioevent-disasters, as well as natural bioevents such as SARS and avian flu pandemics will be an exception and are likely to be followed by PTSD rates approaching those that follow warzone exposure. During bioevents, Amygdala-driven and locus-coeruleus-driven epidemic pseudosomatic symptoms may be an order of magnitude more common than infection-caused cytokine-driven symptoms. Implications for the red cross and FEMA are discussed. It is also argued that hospital phobia as well as dog phobia, bird phobia and bat phobia require re-taxonomization in DSM-V in a new "overconsolidational disorders" category anchored around PTSD. The overconsolidational spectrum category may be conceptualized as straddling the fear circuitry spectrum disorders and the affective spectrum disorders categories, and may be a category for which Pitman's secondary prevention propranolol regimen may be specifically indicated as a "morning after pill" intervention. Predictions are presented regarding obsessive-compulsive disorder (OCD) (e.g., female-pattern hoarding vs. male-pattern hoarding) and "culture-bound" acute anxiety symptoms (taijin-kyofusho, koro, shuk yang, shook yong, suo yang, rok-joo, jinjinia-bemar, karoshi, gwarosa, Voodoo death). Also discussed are insights relevant to pseudoneurological symptoms and to the forthcoming Dissociative-Conversive disorders category in DSM-V, including what the author terms fright-triggered acute pseudo-localized symptoms (i.e., pseudoparalysis, pseudocerebellar imbalance, psychogenic blindness, pseudoseizures, and epidemic sociogenic illness). Speculations based on studies of the human abnormal-spindle-like, microcephaly-associated (ASPM) gene, the microcephaly primary autosomal recessive (MCPH) gene, and the forkhead box p2 (FOXP2) gene are made and incorporated into what is termed "The pre-FOXP2 Hypothesis of Blood-Injection-Injury Phobia." Finally, the author argues for a non-reductionistic fusion of "distal (evolutionary) neurobiology" with clinical "proximal neurobiology," utilizing neurological heuristics. It is noted that the value of re-clustering fear traits based on behavioral ethology, human-phylogenomics-derived endophenotypes and on ontogenomics (gene-environment interactions) can be confirmed or disconfirmed using epidemiological or twin studies and psychiatric genomics

Forms of early walking

Children in the first weeks of independent locomotion display a wide variety of walking forms. The walking forms differ in mechanical strategy and concern with balance. Three extreme walking forms are presented: the Twister, who uses trunk twist, the Faller, who uses gravity, and the Stepper, who remains balanced as much as possible. Each walking form is presented as a ''d-space'', a mathematical format combining continuous and discrete aspects, developed to express the sequence and pattern of a movement without the inappropriate precision of a physical trajectory. The three d-spaces represent analyses of three extreme modes of early walking. They are used to generate the variety of early walking forms and to predict mixtures of mechanical strategies as children mature and converge to more similar walking forms over the first few months of independent locomotion. (C) 1995 Academic Press Limite

Bed-level ventilation conditions in daycare centers

In Dutch daycare centers, most often, semi-enclosed beds are used in bedrooms. Given that air usually does not mix completely in a ventilated room, there are concerns about whether room-level ventilation would be enough to keep the air clean inside semi-enclosed beds. No studies into the bed-level ventilation conditions in daycare centers have been identified. Therefore, a field survey was performed in 17 Dutch daycare centers to collect bedroom ventilation conditions and occupants’ characteristics. Based on that information, a full-scale bedroom identical to that of typical daycare centers was constructed in a climate chamber. The bed-level ventilation conditions were investigated by examining the dispersion and inhalation of CO2 gas exhaled by a breathing thermal baby model while sleeping in a bed. The effect of three variables, i.e., sleep positions (supine, lateral-to-wall, lateral-to-corridor), baby ages (12- and 30-month-old), and ventilation rates (55 and 250 m3/h), were studied. The results showed that excess exhaled CO2 concentration was accumulated inside the semi-enclosed bed in most cases. This indicates that bed-level ventilation conditions are not sufficient enough when only relying on the room-level mixing ventilation mode. The inhaled CO2 concentration of infants sleeping inside the bed was remarkably high, on average, three times higher than the measured values in the room exhaust. The study provides knowledge on the bed-level ventilation conditions in miniature semi-enclosed sleeping spaces under a mixing ventilation mode at room level and highlights the need to improve the air quality inside the baby bed.</p

Navigation as a Source of Geometric Knowledge: Young Children’s Use of Length, Angle, Distance, and Direction in a Reorientation Task

Geometry is one of the highest achievements of our species, but its foundations are obscure. Consistent with longstanding suggestions that geometrical knowledge is rooted in processes guiding navigation, the present study examines potential sources of geometrical knowledge in the navigation processes by which young children establish their sense of orientation. Past research reveals that children reorient both by the shape of the surface layout and the shapes of distinctive landmarks, but it fails to clarify what shape properties children use. The present study explores 2-year-old children’s sensitivity to angle, length, distance and direction by testing disoriented children’s search in a variety of fragmented rhombic and rectangular environments. Children reoriented themselves in accord with surface distances and directions, but they failed to use surface lengths or corner angles either for directional reorientation or as local landmarks. Thus, navigating children navigate by some but not all of the abstract properties captured by formal Euclidean geometry. While navigation systems may contribute to children’s developing geometric understanding, they likely are not the sole source of abstract geometric intuitions.Psycholog

Determining behavioural-based risk to SLODs of urban public open spaces: Key performance indicators definition and application on established built environment typological scenarios

A behavioural-based approach can be used to assess how users’ reactions to surrounding environmental conditions can alter the urban Built Environment (BE) risk to Slow Onset Disasters (SLODs). Public Open Spaces (POSs) in the BE are relevant scenarios, due to micro-climate-related stress, users’ vulnerabilities (e.g., age, health frailty) and exposure time. Simulation methods can support behavioural-based risk-assessment, but results are generally site-specific. Performing analysis on BE Typologies (BETs) can improve robustness, since BETs represent archetypes from real-world scenarios. This work adopts a behavioural-based approach to evaluate time-dependant users’ risks of POSs in different BETs due to SLODs-related stress (i.e., heat, air pollution). UTCI and AQI values are mapped within each BET. Users’ distributions are then calculated depending on thermal acceptability correlations. Key Performance Indicators are developed associating users’ distribution to SLODs effects on health (i.e., sweat rate, water loss; health affection rate probability). The approach is applied to Italian BETs, under one relevant climate, rating their heat and air pollution risks. Results suggest critical conditions for toddlers. In detail, about 2-hour high heat exposure could result in dehydration, while 1-hour exposure to low NO2 concentration could result in +1% mortality probability. This approach could potentially support decision-makers on BE risk-assessment

The Impact of Different Play Environments on the Social Interactions of Toddlers with Disabilities

Play is an important part of supporting social interactions with children, and these interactions are an imperative part of a child’s social development. Social development is a significant challenge for children with disabilities, making play an important component in helping with their development. Different play environments may be better than others in terms of supporting social interactions. In order to determine what types of play environments were best at supporting social interaction, children between 33 and 36 months of age were observed in three different settings. Children that were part of the Lil’ Aggies program—an early intervention program that helps children under the age of 3 with disabilities transition into community and district preschools—were observed on the playground, in the classroom, and in the gym. The social interactions in each of these environments were compared to see if one environment promoted more social interactions than another. A time-sampling procedure was used for the observations in each of the settings. Following the observations, the data were analyzed using an independent sample t-test procedure. It was found that children are more likely to interact with peers on the playground, and more likely to interact with adults in the classroom. It was also found that interactions on the playground were more likely to be positive

Gaming security by obscurity

Shannon sought security against the attacker with unlimited computational powers: *if an information source conveys some information, then Shannon's attacker will surely extract that information*. Diffie and Hellman refined Shannon's attacker model by taking into account the fact that the real attackers are computationally limited. This idea became one of the greatest new paradigms in computer science, and led to modern cryptography. Shannon also sought security against the attacker with unlimited logical and observational powers, expressed through the maxim that "the enemy knows the system". This view is still endorsed in cryptography. The popular formulation, going back to Kerckhoffs, is that "there is no security by obscurity", meaning that the algorithms cannot be kept obscured from the attacker, and that security should only rely upon the secret keys. In fact, modern cryptography goes even further than Shannon or Kerckhoffs in tacitly assuming that *if there is an algorithm that can break the system, then the attacker will surely find that algorithm*. The attacker is not viewed as an omnipotent computer any more, but he is still construed as an omnipotent programmer. So the Diffie-Hellman step from unlimited to limited computational powers has not been extended into a step from unlimited to limited logical or programming powers. Is the assumption that all feasible algorithms will eventually be discovered and implemented really different from the assumption that everything that is computable will eventually be computed? The present paper explores some ways to refine the current models of the attacker, and of the defender, by taking into account their limited logical and programming powers. If the adaptive attacker actively queries the system to seek out its vulnerabilities, can the system gain some security by actively learning attacker's methods, and adapting to them?Comment: 15 pages, 9 figures, 2 tables; final version appeared in the Proceedings of New Security Paradigms Workshop 2011 (ACM 2011); typos correcte

Outdoor Learning and Play

This Open Access book examines children’s participation in dialectical reciprocity with place-based institutional practices by presenting empirical research from Australia, Brazil, China, Poland, Norway and Wales. Underpinned by cultural-historical theory, the analysis reveals how outdoors and nature form unique conditions for children's play, formal and informal learning and cultural formation. The analysis also surfaces how inequalities exist in societies and communities, which often limit and constrain families' and children's access to and participation in outdoor spaces and nature. The findings highlight how institutional practices are shaped by pedagogical content, teachers' training, institutional regulations and societal perceptions of nature, children and suitable, sustainable education for young children. Due to crises, such as climate change and the recent pandemic, specific focus on the outdoors and nature in cultural formation is timely for the cultural-historical theoretical tradition. In doing so, the book provides empirical and theoretical support for policy makers, researchers, educators and families to enhance, increase and sustain outdoor and nature education