How Low Can You Go?

The Clean Clothes Campaign calls attention to the protest of garment workers regarding the failure of the Bangladesh Wage Board to come up with an acceptable minimum wage for the garment industry

How Low Can You Go? The Consequences of Zero Tolerance

Establishing tolerance levels for the presence of unwanted materials that may inadvertently become co-mingled with products that are acceptable in markets is a problem for regulators that requires arbitrary lines in the sand to be drawn. While the degree of tolerance is ultimately an arbitrary value -- because the full information necessary to make a non-arbitrary decision is never forthcoming -- decision making can be informed by theory, existing information, and where gaps in information lie. Where tolerances have been established that do not appear to have been informed, they should be re-examined if for no other reason than they may impose unnecessary costs on society. Zero tolerance has been imposed by regulators in a number of jurisdictions for unwanted materials that could co-mingle with products acceptable in the market. One such case is the European Union's (EU) policy of zero tolerance for co-mingling of unapproved genetically modified (GM) materials with agri-food products. This article uses two case studies related to the regulation of GM materials in the EU to examine the implications of zero tolerance. While the topic of the regulation of modern biotechnology has been the subject of much debate in the EU and globally, there appears to be little discussion of zero tolerance. Given that zero tolerance imposes considerable externalities on non-EU agri-food sectors as well as in the EU itself, it may be time to re-examine zero tolerance in an informed way

How Low Can You Go? Feature Selection for Drug Discovery

The cost of bringing a drug to market depends on how quickly a candidate drug can be “discovered” and evaluated to ensure safety and effectiveness. In this work we develop a method for predicting whether a given drug and protein compound will “bind.” Our aim is to select a set of features to predict drug-protein interactions. This study focuses on kinases. Kinase inhibitors are the largest class of new cancer therapies. Selective inhibition is difficult due to high sequence similarity, leading to off-target interactions and side-effects. Pictured here human c-SRC

How low can you go? Towards a hierarchy of grey literature.

In recent times health sciences librarians have become increasingly involved in working closely with researchers who are undertaking literature reviews (often, but not always, systematic literature reviews). Due to the evidence-based push throughout the medical and health practice area, strong database searching skills have become essential to locate and identify the research necessary to inform practice. These are skills that librarians already have. In hospitals and universities, librarians have been heartened to find their expertise openly acknowledged as their role dovetails neatly into a position of strength. Working with researchers we find our opinions are sought and valued, and this extends to questioning our knowledge of the grey literature. While searching the published (black) literature is a given, there is a growing recognition that grey literature should be included to fully reflect the existing evidential base. Herein lies the rub. Without a clearly established hierarchy, what grey literature is admissible: particularly if we consider grey resources other than the unpublished equivalents of traditional studies and trials? Literature reviews need to include the most significant research available. And that might mean conference papers, reports, legislation or working papers - all grey. This paper examines the variety, relevance, advantages and disadvantages of grey literature and where it might ‘sit’ in the overall research picture

Outcome assessment in low back pain: how low can you go?

The present study examined the psychometric characteristics of a "core-set” of six individual questions (on pain, function, symptom-specific well-being, work disability, social disability and satisfaction) for use in low back pain (LBP) outcome assessment. A questionnaire booklet was administered to 277 German-speaking LBP patients with a range of common diagnoses, before and 6months after surgical (N=187) or conservative (N=90) treatment. The core-set items were embedded in the booklet alongside validated ‘reference' questionnaires: Likert scales for back/leg pain; Roland and Morris disability scale; WHO Quality of Life scale; Psychological General Well-Being Index. A further 45 patients with chronic LBP completed the booklet twice in 1-2weeks. The minimal reliability (similar to Cronbach's alpha) for each core item was 0.42-0.78, increasing to 0.84 for a composite index score comprising all items plus an additional question on general well-being (‘quality of life'). Floor or ceiling effects of 20-50% were observed for some items before surgery (function, symptom-specific well-being) and some items after it (disability, function). The intraclass correlation coefficient (ICC) ("test-retest reliability”) was moderate to excellent (ICC, 0.67-0.95) for the individual core items and excellent (ICC, 0.91) for the composite index score. With the exception of "symptom-specific well-being”, the correlations between each core item and its corresponding reference questionnaire ("validity”) were between 0.61 and 0.79. Both the composite index and the individual items differentiated (P<0.001) between the severity of the back problem in surgical and conservative patients (validity). The composite index score had an effect size (sensitivity to change) of 0.95, which was larger than most of the reference questionnaires (0.47-1.01); for individual core items, the effect sizes were 0.52-0.87. The core items provide a simple, practical, reliable, valid and sensitive assessment of outcome in LBP patients. We recommend the widespread and consistent use of the core-set items and their composite score index to promote standardisation of outcome measurements in clinical trials, multicentre studies, routine quality management and surgical registry system

How low can you go? Bioenactivism, cognitive biology and Umwelt ontology

The viability of enactivist philosophy in providing descriptions of biological phenomena (bioenactivism) across the phylogenetic spectrum relies in large part on the scalability of its central concepts, i.e. whether they remain operative at varying levels of biological complexity. In this paper, I will examine the possibility of scaling two deeply intertwined concepts: cognition and surrounding world (Umwelt). Contra some indications from Varela and others, I will argue that the concept of embodied cognition can be scaled down below the level of the organism. I will draw upon the “cognitive biology” espoused by Kováč (2000, 2006) and Monod’s (1971) studies of protein behaviour to make this case. The downscaling of embodied cognition below the level of the organism has ramifications for how we understand the concept of surrounding world (Umwelt). Reconfiguring the relation between these two central bioenactive concepts has further consequences for what ontological commitments bioenactive thinking leads to, and what paths of investigation it points us toward

Tidal modulation of river-flood deposits: How low can you go?

Quantification of the interaction between river discharge and tides is vital to characterize fluvio-deltaic systems, to identify diagnostic elements of tidal signatures in the rock record, and to reconstruct paleogeographies. In modern systems, even microtides can significantly influence delta morphodynamics; yet, many fundamental processes, particularly in prodeltaic settings, remain elusive. Here, by combining a unique process-product data set acquired during a flood event of the Po River (Italy) with numerical modeling, we show that tidal signatures are recorded in the open-water prodelta zone of a microtidal system. Based on the analyses of box-cores collected before and after a flood off the main distributary channel, we interpreted storm beds, tide-modulated flood strata of alternating normal and inverse graded beds, and rapid bioturbation. Modeling of the river discharge indicates that, at the peak of the flood, the steepening of the water-surface profile forced by 0.15 m lowering of sea level during low tides generated an 8% increase in river flow velocity. The alternation of profile steepness and associated cyclicity in flow strength during consecutive tidal cycles controlled the sediment load of the plume and, consequently, led to the deposition of tidal-modulated strata. Formation of microtidal signals appears to be enhanced in fluvio-deltaic successions characterized by multiple distributaries and in basins where river floods are out of phase with storm-wave activity. Bioturbation of sediment, which can start during the waning stage of the flow, and erosion by storm waves hamper the preservation of tidal signals, unless rapid burial occurs. The recognition of tidal-modulated strata in river-dominated settings may facilitate the characterization of mudstone reservoirs and reconstruction of paleogeographic conditions during deposition

How low can you go? Human limits in small unidirectional mouse movements

International audienceComputer mouse sensors keep increasing in resolution. The smallest displacement they can detect gets smaller, but little is known on our ability to control such small movements. Small target acquisition has been previously tackled, but the findings do not apply to the problem of finding the useful resolution of a user with a mouse, which corresponds to the smallest displacement (s)he can reliably produce with that device. We detail this definition and provide an associated experimental protocol to measure it. We then report on the results of a study suggesting that high-end mice are not likely to be used to their full potential. We further comment on the different strategies used by participants to acheive best performance, and derive implications for user interfaces