Functional MRI during hippocampal deep brain stimulation in the healthy rat brain

Deep Brain Stimulation (DBS) is a promising treatment for neurological and psychiatric disorders. The mechanism of action and the effects of electrical fields administered to the brain by means of an electrode remain to be elucidated. The effects of DBS have been investigated primarily by electrophysiological and neurochemical studies, which lack the ability to investigate DBS-related responses on a whole-brain scale. Visualization of whole-brain effects of DBS requires functional imaging techniques such as functional Magnetic Resonance Imaging (fMRI), which reflects changes in blood oxygen level dependent (BOLD) responses throughout the entire brain volume. In order to visualize BOLD responses induced by DBS, we have developed an MRI-compatible electrode and an acquisition protocol to perform DBS during BOLD fMRI. In this study, we investigate whether DBS during fMRI is valuable to study local and whole-brain effects of hippocampal DBS and to investigate the changes induced by different stimulation intensities. Seven rats were stereotactically implanted with a custom-made MRI-compatible DBS-electrode in the right hippocampus. High frequency Poisson distributed stimulation was applied using a block-design paradigm. Data were processed by means of Independent Component Analysis. Clusters were considered significant when p-values were <0.05 after correction for multiple comparisons. Our data indicate that real-time hippocampal DBS evokes a bilateral BOLD response in hippocampal and other mesolimbic structures, depending on the applied stimulation intensity. We conclude that simultaneous DBS and fMRI can be used to detect local and whole-brain responses to circuit activation with different stimulation intensities, making this technique potentially powerful for exploration of cerebral changes in response to DBS for both preclinical and clinical DBS

Observing FRB 121102 with VERITAS; Searching for Associated TeV Emission

Fast radio bursts are bright, unresolved and short flashes of radio emission originating from outside the Milky Way. The origin of these mysterious outbursts is unknown, but their high luminosity and short duration has prompted much speculation. The discovery that FRB 121102 repeats has enabled multiwavelength follow up, which has identified the host galaxy. VERITAS has observed the location of FRB 121102, including coincident observations with Arecibo. We present the results of a search for steady very high energy gamma-ray emission and the methodology for searching for short timescale, transient optical and very high energy gamma-ray emission.Comment: 8 pages, 1 figure, 1 table. In Proceedings of the 35th International Cosmic Ray Conference (ICRC 2017), Busan (South Korea

A NICER Discovery of a Low-Frequency Quasi-Periodic Oscillation in the Soft-Intermediate State of MAXI J1535-571

We present the discovery of a low-frequency $\approx 5.7$ Hz quasi-periodic oscillation (QPO) feature in observations of the black hole X-ray binary MAXI J1535-571 in its soft-intermediate state, obtained in September-October 2017 by the Neutron Star Interior Composition Explorer (NICER). The feature is relatively broad (compared to other low-frequency QPOs; quality factor $Q\approx 2$) and weak (1.9% rms in 3-10 keV), and is accompanied by a weak harmonic and low-amplitude broadband noise. These characteristics identify it as a weak Type A/B QPO, similar to ones previously identified in the soft-intermediate state of the transient black hole X-ray binary XTE J1550-564. The lag-energy spectrum of the QPO shows increasing soft lags towards lower energies, approaching 50 ms at 1 keV (with respect to a 3-10 keV continuum). This large phase shift has similar amplitude but opposite sign to that seen in Rossi X-ray Timing Explorer data for a Type B QPO from the transient black hole X-ray binary GX 339-4. Previous phase-resolved spectroscopy analysis of the Type B QPO in GX 339-4 pointed towards a precessing jet-like corona illuminating the accretion disk as the origin of the QPO signal. We suggest that this QPO in MAXI J1535-571 may have the same origin, with the different lag sign depending on the scale height of the emitting region and the observer inclination angle.Comment: Accepted for publication in ApJ Letter

Discovery of kHz Fluctuations in Centaurus X-3: Evidence for Photon Bubble Oscillations (PBO) and Turbulence in a High Mass X-ray Binary Pulsar

We report the discovery of kHz fluctuations, including quasi-periodic oscillations (QPO) at ~330 Hz and ~760 Hz and a broadband kHz continuum in the power density spectrum of the high mass X-ray binary pulsar Centaurus X-3. These observations of Cen X-3 were carried out with the Rossi X-ray Timing Explorer (RXTE). The fluctuation spectrum is flat from mHz to a few Hz, then steepens to $f^{-2}$ behavior between a few Hz and ~100 Hz. Above a hundred Hz, the spectrum shows the QPO features, plus a flat continuum extending to ~1200 Hz and then falling out to ~1800 Hz. These results, which required the co-adding three days of observations of Cen X-3, are at least as fast as the fastest known variations in X-ray emission from an accreting compact object (kHz QPO in LMXB sources) and probably faster since extension to ~1800 Hz is indicated by the most likely parameterization of the data. Multi-dimensional radiation hydrodynamics simulations of optically thick plasma flow onto the magnetic poles of an accreting neutron star show that the fluctuations at frequencies above 100 Hz are consistent with photon bubble turbulence and oscillations (PBO) previously predicted to be observable in this source. For a polar cap opening angle of 0.25 radians, we show that the spectral form above 100 Hz is reproduced by the simulations, including the frequencies of the QPO and the relative power in the QPO and the kHz continuum. This has resulted in the first model-dependent measurement of the polar cap size of an X-ray pulsar.Comment: received ApJ: April 1, 1999 accepted ApJ: September 1, 199

Detection of Very Low-Frequency Quasi-Periodic Oscillations in the 2015 Outburst of V404 Cygni

In June 2015, the black hole X-ray binary (BHXRB) V404 Cygni went into outburst for the first time since 1989. Here, we present a comprehensive search for quasi-periodic oscillations (QPOs) of V404 Cygni during its recent outburst, utilizing data from six instruments on board five different X-ray missions: Swift/XRT, Fermi/GBM, Chandra/ACIS, INTEGRAL's IBIS/ISGRI and JEM-X, and NuSTAR. We report the detection of a QPO at 18 mHz simultaneously with both Fermi/GBM and Swift/XRT, another example of a rare but slowly growing new class of mHz-QPOs in BHXRBs linked to sources with a high orbital inclination. Additionally, we find a duo of QPOs in a Chandra/ACIS observation at 73 mHz and 1.03 Hz, as well as a QPO at 136 mHz in a single Swift/XRT observation that can be interpreted as standard Type-C QPOs. Aside from the detected QPOs, there is significant structure in the broadband power, with a strong feature observable in the Chandra observations between 0.1 and 1 Hz. We discuss our results in the context of current models for QPO formation.Comment: 17 pages, 9 figures, published in Ap

The effects of periodic and non-periodic inputs on the dynamics of a medial entorhinal cortex layer II stellate cell model

Various neuron types exhibit sub-threshold and firing frequency resonance in which the sub-threshold membrane potential or firing frequency responses to periodic inputs peak at a preferred frequency (or frequencies). Previous experimental work has shown that medial entorhinal cortex layer II stellate cells (SCs) exhibit sub-threshold and firing frequency resonance in the theta frequency band (4 - 10 Hz). In this thesis we seek to understand the biophysical and dynamic mechanism underlying these phenomena and how they are related. We studied the effects of sinusoidal current and synaptic conductance inputs at various frequencies, with and without noise, on the supra-threshold dynamics of a SC model. For current inputs, our results show that while the SC model exhibits a single frequency preference peak (in the theta frequency band) for low sinusoidal input levels, it exhibits three preferred frequency peaks for larger input levels. These additional peaks occur at frequencies that are roughly a multiple of the theta one. For synaptic conductance inputs, we observe an additional peak in the signal gain which occurs at a much higher frequency (in the high gamma frequency band). These findings depart from the linear prediction. The corresponding linearized model does not exhibit three preferred frequency peaks for current inputs and a much higher frequency for conductance inputs under the same conditions (such as parameters, noise, amplitude of inputs and maximal synaptic conductance) in the nonlinear model. Previous experimental work has shown high-frequency Poisson-distributed trains of combined excitatory and inhibitory conductance- and current-based synaptic inputs reduce amplitude of subthreshold oscillations of SCs. The second goal of this thesis is to investigate the mechanism underlying these phenomena in the context of the model. More specially, we studied the effects of both conductance- and current-based synaptic inputs at various maximal conductance values on a SC model. Our numerical simulations show that conductance-based synaptic inputs reduce the amplitude of SC\u27s subthreshold oscillations for low enough value of the maximal synaptic conductance value but amplify these oscillations at a higher range. These results are in contrast to the experimental results