23,371 research outputs found
Implicit and Implicit-Explicit Strong Stability Preserving Runge-Kutta Methods with High Linear Order
When evolving in time the solution of a hyperbolic partial differential
equation, it is often desirable to use high order strong stability preserving
(SSP) time discretizations. These time discretizations preserve the
monotonicity properties satisfied by the spatial discretization when coupled
with the first order forward Euler, under a certain time-step restriction.
While the allowable time-step depends on both the spatial and temporal
discretizations, the contribution of the temporal discretization can be
isolated by taking the ratio of the allowable time-step of the high order
method to the forward Euler time-step. This ratio is called the strong
stability coefficient. The search for high order strong stability time-stepping
methods with high order and large allowable time-step had been an active area
of research. It is known that implicit SSP Runge-Kutta methods exist only up to
sixth order. However, if we restrict ourselves to solving only linear
autonomous problems, the order conditions simplify and we can find implicit SSP
Runge-Kutta methods of any linear order. In the current work we aim to find
very high linear order implicit SSP Runge-Kutta methods that are optimal in
terms of allowable time-step. Next, we formulate an optimization problem for
implicit-explicit (IMEX) SSP Runge-Kutta methods and find implicit methods with
large linear stability regions that pair with known explicit SSP Runge-Kutta
methods of orders plin=3,4,6 as well as optimized IMEX SSP Runge-Kutta pairs
that have high linear order and nonlinear orders p=2,3,4. These methods are
then tested on sample problems to verify order of convergence and to
demonstrate the sharpness of the SSP coefficient and the typical behavior of
these methods on test problems
Optimized explicit Runge-Kutta schemes for the spectral difference method applied to wave propagation problems
Explicit Runge-Kutta schemes with large stable step sizes are developed for
integration of high order spectral difference spatial discretization on
quadrilateral grids. The new schemes permit an effective time step that is
substantially larger than the maximum admissible time step of standard explicit
Runge-Kutta schemes available in literature. Furthermore, they have a small
principal error norm and admit a low-storage implementation. The advantages of
the new schemes are demonstrated through application to the Euler equations and
the linearized Euler equations.Comment: 37 pages, 3 pages of appendi
Extrapolation-Based Implicit-Explicit Peer Methods with Optimised Stability Regions
In this paper we investigate a new class of implicit-explicit (IMEX) two-step
methods of Peer type for systems of ordinary differential equations with both
non-stiff and stiff parts included in the source term. An extrapolation
approach based on already computed stage values is applied to construct IMEX
methods with favourable stability properties. Optimised IMEX-Peer methods of
order p = 2, 3, 4, are given as result of a search algorithm carefully designed
to balance the size of the stability regions and the extrapolation errors.
Numerical experiments and a comparison to other implicit-explicit methods are
included.Comment: 21 pages, 6 figure
A Continuum Poisson-Boltzmann Model for Membrane Channel Proteins
Membrane proteins constitute a large portion of the human proteome and
perform a variety of important functions as membrane receptors, transport
proteins, enzymes, signaling proteins, and more. The computational studies of
membrane proteins are usually much more complicated than those of globular
proteins. Here we propose a new continuum model for Poisson-Boltzmann
calculations of membrane channel proteins. Major improvements over the existing
continuum slab model are as follows: 1) The location and thickness of the slab
model are fine-tuned based on explicit-solvent MD simulations. 2) The highly
different accessibility in the membrane and water regions are addressed with a
two-step, two-probe grid labeling procedure, and 3) The water pores/channels
are automatically identified. The new continuum membrane model is optimized (by
adjusting the membrane probe, as well as the slab thickness and center) to best
reproduce the distributions of buried water molecules in the membrane region as
sampled in explicit water simulations. Our optimization also shows that the
widely adopted water probe of 1.4 {\AA} for globular proteins is a very
reasonable default value for membrane protein simulations. It gives an overall
minimum number of inconsistencies between the continuum and explicit
representations of water distributions in membrane channel proteins, at least
in the water accessible pore/channel regions that we focus on. Finally, we
validate the new membrane model by carrying out binding affinity calculations
for a potassium channel, and we observe a good agreement with experiment
results.Comment: 40 pages, 6 figures, 5 table
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