A Harmonized and Reversible Development Framework for HLA-Based Interoperable Application

International audienceEnterprise collaboration is becoming more and more important because of the globalized economic context. The competitiveness of enterprises depends not only on their internal productivity and performance, but also on their ability to collaborate with others. This necessity leads to the development of interoperability, which makes it possible to improve collaborations between enterprises. Therefore, more and more networked enterprises are being developed. Further, enterprise interoperability is one of the most suitable solutions to total enterprise integration

Building a high-level architecture federated interoperable framework from legacy information systems

International audienceThis paper aims at improving the re-implementation of existing information systems when they are called to be involved in a system of systems, i.e. a federation of enterprise information systems that interoperate. The idea is reusing the local experiences coming from the previous development of the existing information system with the process of model discovery. To avoid redeveloping the entire system when the enterprise needs to cooperate with others, this approach proposes to create local interfaces to code and decode information. The interfaces are instantiated by using models discovered. The interfaces are developed in accordance with the high-level architecture (HLA) standard that proposes message interoperability and synchronisation mechanisms among distributed systems. First, this paper recalls the strong points of model-driven architecture (MDA)/architecture-driven modernisation methodologies for model transformation from conceptual level to implementation and the HLA standard. Then, a MDA and HLA framework is proposed to implement distributed enterprise components from the conceptual level through a federated enterprise interoperability approach. In addition, a model reversal methodology is developed under the framework to guide the re-implementation of legacy information systems to achieve desired interoperability with other systems. To extend the scope of the approach, implemented Web services are combined with HLA in order to facilitate the use of HLA in large distributed execution. This paper ends with an implementation example for validating the approach

Unified Reversible Life Cycle for Future Interoperable Enterprise Distributed Information Systems

Best Paper AwardInternational audienceThis paper aims at improving the re-implementation of existing information systems when they are called to be involved in a system of systems, i.e. a federation of enterprise information systems that interoperate. The idea is reusing the local experiences coming from the development of the original information system with the process of Model Discovery and Ontological approach. We give first, a review of ongoing researches on Enterprise Interoperability. The MDA can help to transform concepts and models from the conceptual level to the implementation. The HLA standard, initially designed for military M&S purpose, can be transposed for enterprise interoperability at the implementation level, reusing the years of experiences in distributed systems. From these postulates, we propose a MDA/HLA lifecycle to implement distributed enterprise models from the conceptual level of federated enterprise interoperability approach. In addition to this classical development, we propose a model reversal methodology to help re-implement the legacy information system, in order to achieve the interoperability with other systems

Federated approach for enterprise interoperability (a reversible model driven and HLA based methodology)

L'interopérabilité est une des caractéristiques requises pour les entreprises évoluant dans un marché globalisé à la concurrence croissante et complexe. Dans la dernière décennie, l'interopérabilité des entreprises a été développée et prescrite par différents types de cadres, de méthodes et de techniques. Cependant, le développement de l'interopérabilité n'est pas encore assez mature pour être considéré en tant que science à part entière. Par ailleurs, il ne cesse d'évoluer en fonction des besoins des entreprises,de leurs environnements et des différents secteurs d activité. Aujourd'hui, l'environnement s organise en réseaux multipleet provoque d imprévisibles situations liées à leurs dynamiques (création, modification, résilience). Ainsi l interopérabilité durable devient une dimension nouvelle de recherche pour l'interopérabilité des systèmes d'entreprise et de leurs domaines d'applications. Dans l'interopérabilité durable, l'interopérabilité d'entreprise dynamique est l'un des thèmes focaux. Cette approche dynamique, également appelée fédérée , est originaire du cadre d'interopérabilité de l'Entreprise proposée dans le Réseau d Excellence (NoE)INTEROP. Il vise à donner la capacité aux entreprises d établir une interopérabilité à la volée sans connaissance préalable des informations à échanger. Cette thèse présente l'état actuel des travaux qui se rapprochent du développement de l'interopérabilité des entreprises fédérés en dynamique. Ces travaux de thèse mettent tout d abord en évidence l intérêt de la redécouverte de modèles à partir d un système existant avant de concevoir un futur système. Une méthodologie de réverse engineering dirigée par les modèles et basée sur la norme de simulation distribuée HLA est proposée pour concevoir et développerpar l'approche fédérée d'interopérabilité le futur système d information de l entreprise. La phase de mise en œuvre réutilise les concepts d interopérabilité issusde la simulation distribuée pour faciliter et coordonner la communication entre les systèmes d'information distribués hétérogènes des entreprises en combinant avec les dernières orientation service actuelle du web. La plate-forme tend ainsi à satisfaire les attentes de la dernière version du standard de l'architecture de haut niveau HLA 1516 Evolved. Ce cadre propose donc un cycle complet de développement pour qui a l'intention de réutiliser un système d'information existant sans recoder ex-nilo, mais en l adaptant aux nouvelles exigences de la dynamique d'interopérabilité.Interoperability is one of the requisite features for existing enterprises in the increasing competitive and complex global market. In the last decade, enterprise interoperability has been developed and prescribed by various kinds of frameworks, methods, and techniques. However interoperability development is still not mature enough to become a science. Meanwhile, it keeps evolving according to different business requirement and market environment. Nowadays, networked environment causes unpredictable dynamical situations, thus sustainable interoperability becomes a new research dimension in the interoperability of enterprise systems and applications domain. In the sustainable interoperability, enterprise interoperability dynamics is one of the focal topics. This dynamic approach also called federated is originated from Enterprise Interoperability Framework of INTEROP NoE, which aims to establish interoperability on the fly. This thesis presents current state on federated approaches to develop enterprise interoperability dynamics. Based on this study, a reversible model driven and HLA based methodology is proposed for achieving federated approach for Enterprise Interoperability. It reuses distributed simulation interoperability concepts to facilitate and coordinate the communication between heterogeneous distributed information systems of the enterprises. The platform is complaint with the latest version of the High Level Architecture (HLA) that is a distributed communication standard. This framework is also proposing a development lifecycle that intends to reuse existing information systems without recoding them but by adapting them to the new requirements of interoperability dynamics.BORDEAUX1-Bib.electronique (335229901) / SudocSudocFranceF

Cognitive Hyperconnected Digital Transformation

Cognitive Hyperconnected Digital Transformation provides an overview of the current Internet of Things (IoT) landscape, ranging from research, innovation and development priorities to enabling technologies in a global context. It is intended as a standalone book in a series that covers the Internet of Things activities of the IERC-Internet of Things European Research Cluster, including both research and technological innovation, validation and deployment. The book builds on the ideas put forward by the European Research Cluster, the IoT European Platform Initiative (IoT-EPI) and the IoT European Large-Scale Pilots Programme, presenting global views and state-of-the-art results regarding the challenges facing IoT research, innovation, development and deployment in the next years. Hyperconnected environments integrating industrial/business/consumer IoT technologies and applications require new IoT open systems architectures integrated with network architecture (a knowledge-centric network for IoT), IoT system design and open, horizontal and interoperable platforms managing things that are digital, automated and connected and that function in real-time with remote access and control based on Internet-enabled tools. The IoT is bridging the physical world with the virtual world by combining augmented reality (AR), virtual reality (VR), machine learning and artificial intelligence (AI) to support the physical-digital integrations in the Internet of mobile things based on sensors/actuators, communication, analytics technologies, cyber-physical systems, software, cognitive systems and IoT platforms with multiple functionalities. These IoT systems have the potential to understand, learn, predict, adapt and operate autonomously. They can change future behaviour, while the combination of extensive parallel processing power, advanced algorithms and data sets feed the cognitive algorithms that allow the IoT systems to develop new services and propose new solutions. IoT technologies are moving into the industrial space and enhancing traditional industrial platforms with solutions that break free of device-, operating system- and protocol-dependency. Secure edge computing solutions replace local networks, web services replace software, and devices with networked programmable logic controllers (NPLCs) based on Internet protocols replace devices that use proprietary protocols. Information captured by edge devices on the factory floor is secure and accessible from any location in real time, opening the communication gateway both vertically (connecting machines across the factory and enabling the instant availability of data to stakeholders within operational silos) and horizontally (with one framework for the entire supply chain, across departments, business units, global factory locations and other markets). End-to-end security and privacy solutions in IoT space require agile, context-aware and scalable components with mechanisms that are both fluid and adaptive. The convergence of IT (information technology) and OT (operational technology) makes security and privacy by default a new important element where security is addressed at the architecture level, across applications and domains, using multi-layered distributed security measures. Blockchain is transforming industry operating models by adding trust to untrusted environments, providing distributed security mechanisms and transparent access to the information in the chain. Digital technology platforms are evolving, with IoT platforms integrating complex information systems, customer experience, analytics and intelligence to enable new capabilities and business models for digital business

Cognitive Hyperconnected Digital Transformation

Cognitive Hyperconnected Digital Transformation provides an overview of the current Internet of Things (IoT) landscape, ranging from research, innovation and development priorities to enabling technologies in a global context. It is intended as a standalone book in a series that covers the Internet of Things activities of the IERC-Internet of Things European Research Cluster, including both research and technological innovation, validation and deployment. The book builds on the ideas put forward by the European Research Cluster, the IoT European Platform Initiative (IoT-EPI) and the IoT European Large-Scale Pilots Programme, presenting global views and state-of-the-art results regarding the challenges facing IoT research, innovation, development and deployment in the next years. Hyperconnected environments integrating industrial/business/consumer IoT technologies and applications require new IoT open systems architectures integrated with network architecture (a knowledge-centric network for IoT), IoT system design and open, horizontal and interoperable platforms managing things that are digital, automated and connected and that function in real-time with remote access and control based on Internet-enabled tools. The IoT is bridging the physical world with the virtual world by combining augmented reality (AR), virtual reality (VR), machine learning and artificial intelligence (AI) to support the physical-digital integrations in the Internet of mobile things based on sensors/actuators, communication, analytics technologies, cyber-physical systems, software, cognitive systems and IoT platforms with multiple functionalities. These IoT systems have the potential to understand, learn, predict, adapt and operate autonomously. They can change future behaviour, while the combination of extensive parallel processing power, advanced algorithms and data sets feed the cognitive algorithms that allow the IoT systems to develop new services and propose new solutions. IoT technologies are moving into the industrial space and enhancing traditional industrial platforms with solutions that break free of device-, operating system- and protocol-dependency. Secure edge computing solutions replace local networks, web services replace software, and devices with networked programmable logic controllers (NPLCs) based on Internet protocols replace devices that use proprietary protocols. Information captured by edge devices on the factory floor is secure and accessible from any location in real time, opening the communication gateway both vertically (connecting machines across the factory and enabling the instant availability of data to stakeholders within operational silos) and horizontally (with one framework for the entire supply chain, across departments, business units, global factory locations and other markets). End-to-end security and privacy solutions in IoT space require agile, context-aware and scalable components with mechanisms that are both fluid and adaptive. The convergence of IT (information technology) and OT (operational technology) makes security and privacy by default a new important element where security is addressed at the architecture level, across applications and domains, using multi-layered distributed security measures. Blockchain is transforming industry operating models by adding trust to untrusted environments, providing distributed security mechanisms and transparent access to the information in the chain. Digital technology platforms are evolving, with IoT platforms integrating complex information systems, customer experience, analytics and intelligence to enable new capabilities and business models for digital business

Program and abstracts

We are pleased that the program in 2022 will be more interesting than ever and it will include the following topics: Mathematical Modeling in Cancer Therapy, Gene Therapy, Archaeological Genetics, New perspectives in Human Forensic Molecular Biology, Genomics in Medicine, Pharmacogenomics and Drug Development, Stem Cells in Medicine, Regenerative Medicine, Ribosomes in Medicine, Epigenomics, Crime Scene Investigation, Forensic Genetics, and Mass Catastrophes Managements. This year, the third "Nobel Spirit" will provide a forum to the three Nobel laureates to stimulate public discussion on the role of science in solving global health issues, acute regional problems such as brain drain, demographic decline, as well as cultural and social change. In addition, we are organizing a very stimulating Session on Bioanthropology and global health in the times of crisis, as well as Joint Event ISABS and Ministry of the Interior - Crime Scene Investigation Training Course: Mystery on the ship —Investigation of the water-related crime scene

12th EASN International Conference on "Innovation in Aviation & Space for opening New Horizons"

Epoxy resins show a combination of thermal stability, good mechanical performance, and durability, which make these materials suitable for many applications in the Aerospace industry. Different types of curing agents can be utilized for curing epoxy systems. The use of aliphatic amines as curing agent is preferable over the toxic aromatic ones, though their incorporation increases the flammability of the resin. Recently, we have developed different hybrid strategies, where the sol-gel technique has been exploited in combination with two DOPO-based flame retardants and other synergists or the use of humic acid and ammonium polyphosphate to achieve non-dripping V-0 classification in UL 94 vertical flame spread tests, with low phosphorous loadings (e.g., 1-2 wt%). These strategies improved the flame retardancy of the epoxy matrix, without any detrimental impact on the mechanical and thermal properties of the composites. Finally, the formation of a hybrid silica-epoxy network accounted for the establishment of tailored interphases, due to a better dispersion of more polar additives in the hydrophobic resin

Development and application of methodologies and infrastructures for cancer genome analysis within Personalized Medicine

Programa de Doctorat en Biomedicina / Tesi realitzada al Barcelona Supercomputing Cener (BSC)[eng] Next-generation sequencing (NGS) has revolutionized biomedical sciences, especially in the area of cancer. It has nourished genomic research with extensive collections of sequenced genomes that are investigated to untangle the molecular bases of disease, as well as to identify potential targets for the design of new treatments. To exploit all this information, several initiatives have emerged worldwide, among which the Pan-Cancer project of the ICGC (International Cancer Genome Consortium) stands out. This project has jointly analyzed thousands of tumor genomes of different cancer types in order to elucidate the molecular bases of the origin and progression of cancer. To accomplish this task, new emerging technologies, including virtualization systems such as virtual machines or software containers, were used and had to be adapted to various computing centers. The portability of this system to the supercomputing infrastructure of the BSC (Barcelona Supercomputing Center) has been carried out during the first phase of the thesis. In parallel, other projects promote the application of genomics discoveries into the clinics. This is the case of MedPerCan, a national initiative to design a pilot project for the implementation of personalized medicine in oncology in Catalonia. In this context, we have centered our efforts on the methodological side, focusing on the detection and characterization of somatic variants in tumors. This step is a challenging action, due to the heterogeneity of the different methods, and an essential part, as it lays at the basis of all downstream analyses. On top of the methodological section of the thesis, we got into the biological interpretation of the results to study the evolution of chronic lymphocytic leukemia (CLL) in a close collaboration with the group of Dr. Elías Campo from the Hospital Clínic/IDIBAPS. In the first study, we have focused on the Richter transformation (RT), a transformation of CLL into a high-grade lymphoma that leads to a very poor prognosis and with unmet clinical needs. We found that RT has greater genomic, epigenomic and transcriptomic complexity than CLL. Its genome may reflect the imprint of therapies that the patients received prior to RT, indicating the presence of cells exposed to these mutagenic treatments which later expand giving rise to the clinical manifestation of the disease. Multiple NGS- based techniques, including whole-genome sequencing and single-cell DNA and RNA sequencing, among others, confirmed the pre-existence of cells with the RT characteristics years before their manifestation, up to the time of CLL diagnosis. The transcriptomic profile of RT is remarkably different from that of CLL. Of particular importance is the overexpression of the OXPHOS pathway, which could be used as a therapeutic vulnerability. Finally, in a second study, the analysis of a case of CLL in a young adult, based on whole genome and single-cell sequencing at different times of the disease, revealed that the founder clone of CLL did not present any somatic driver mutations and was characterized by germline variants in ATM, suggesting its role in the origin of the disease, and highlighting the possible contribution of germline variants or other non-genetic mechanisms in the initiation of CLL