Bayesian Spatial Binary Regression for Label Fusion in Structural Neuroimaging

Many analyses of neuroimaging data involve studying one or more regions of interest (ROIs) in a brain image. In order to do so, each ROI must first be identified. Since every brain is unique, the location, size, and shape of each ROI varies across subjects. Thus, each ROI in a brain image must either be manually identified or (semi-) automatically delineated, a task referred to as segmentation. Automatic segmentation often involves mapping a previously manually segmented image to a new brain image and propagating the labels to obtain an estimate of where each ROI is located in the new image. A more recent approach to this problem is to propagate labels from multiple manually segmented atlases and combine the results using a process known as label fusion. To date, most label fusion algorithms either employ voting procedures or impose prior structure and subsequently find the maximum a posteriori estimator (i.e., the posterior mode) through optimization. We propose using a fully Bayesian spatial regression model for label fusion that facilitates direct incorporation of covariate information while making accessible the entire posterior distribution. We discuss the implementation of our model via Markov chain Monte Carlo and illustrate the procedure through both simulation and application to segmentation of the hippocampus, an anatomical structure known to be associated with Alzheimer's disease.Comment: 24 pages, 10 figure

Intelligent Painter: Picture Composition With Resampling Diffusion Model

Have you ever thought that you can be an intelligent painter? This means that you can paint a picture with a few expected objects in mind, or with a desirable scene. This is different from normal inpainting approaches for which the location of specific objects cannot be determined. In this paper, we present an intelligent painter that generate a person's imaginary scene in one go, given explicit hints. We propose a resampling strategy for Denoising Diffusion Probabilistic Model (DDPM) to intelligently compose unconditional harmonized pictures according to the input subjects at specific locations. By exploiting the diffusion property, we resample efficiently to produce realistic pictures. Experimental results show that our resampling method favors the semantic meaning of the generated output efficiently and generates less blurry output. Quantitative analysis of image quality assessment shows that our method produces higher perceptual quality images compared with the state-of-the-art methods.Comment: ICIP 202

Unsupervised deep learning research and implementation of variational autoencoders

Generative models have been one of the major research fields in unsupervised deep learning during the last years. They are achieving promising results in learning the distribution of multidimensional variables as well as in finding meaningful hidden representations in data. The aim of this thesis is to gain a sound understanding of generative models through a profound study of one of the most promising and widely used generative models family, the variational autoencoders. In particular, the performance of the standard variational autoencoder (known as VAE) and the Gaussian Mixture variational autoencoder (called GMVAE) is assessed. First, the mathematical and probabilistic basis of both models is presented. Then, the models are implemented in Python using the Tensorflow framework. The source code is freely available and documented in a personal GitHub repository created for this thesis. Later, the performance of the implemented models is appraised in terms of generative capabilities and interpretability of the hidden representation of the inputs. Two real datasets are used during the experiments, the MNIST and "Frey faces". Results show the models implemented work correctly, and they also show the GMVAE outweighs the performance of the standard VAE, as expected.Ingeniería en Tecnologías de Telecomunicació

Artificial intelligence for dementia prevention

INTRODUCTION: A wide range of modifiable risk factors for dementia have been identified. Considerable debate remains about these risk factors, possible interactions between them or with genetic risk, and causality, and how they can help in clinical trial recruitment and drug development. Artificial intelligence (AI) and machine learning (ML) may refine understanding.// METHODS: ML approaches are being developed in dementia prevention. We discuss exemplar uses and evaluate the current applications and limitations in the dementia prevention field.// RESULTS: Risk-profiling tools may help identify high-risk populations for clinical trials; however, their performance needs improvement. New risk-profiling and trial-recruitment tools underpinned by ML models may be effective in reducing costs and improving future trials. ML can inform drug-repurposing efforts and prioritization of disease-modifying therapeutics.// DISCUSSION: ML is not yet widely used but has considerable potential to enhance precision in dementia prevention

SNIP: Bridging Mathematical Symbolic and Numeric Realms with Unified Pre-training

In an era where symbolic mathematical equations are indispensable for modeling complex natural phenomena, scientific inquiry often involves collecting observations and translating them into mathematical expressions. Recently, deep learning has emerged as a powerful tool for extracting insights from data. However, existing models typically specialize in either numeric or symbolic domains, and are usually trained in a supervised manner tailored to specific tasks. This approach neglects the substantial benefits that could arise from a task-agnostic unified understanding between symbolic equations and their numeric counterparts. To bridge the gap, we introduce SNIP, a Symbolic-Numeric Integrated Pre-training, which employs joint contrastive learning between symbolic and numeric domains, enhancing their mutual similarities in the pre-trained embeddings. By performing latent space analysis, we observe that SNIP provides cross-domain insights into the representations, revealing that symbolic supervision enhances the embeddings of numeric data and vice versa. We evaluate SNIP across diverse tasks, including symbolic-to-numeric mathematical property prediction and numeric-to-symbolic equation discovery, commonly known as symbolic regression. Results show that SNIP effectively transfers to various tasks, consistently outperforming fully supervised baselines and competing strongly with established task-specific methods, especially in few-shot learning scenarios where available data is limited

Zero-shot Medical Image Translation via Frequency-Guided Diffusion Models

Recently, the diffusion model has emerged as a superior generative model that can produce high quality and realistic images. However, for medical image translation, the existing diffusion models are deficient in accurately retaining structural information since the structure details of source domain images are lost during the forward diffusion process and cannot be fully recovered through learned reverse diffusion, while the integrity of anatomical structures is extremely important in medical images. For instance, errors in image translation may distort, shift, or even remove structures and tumors, leading to incorrect diagnosis and inadequate treatments. Training and conditioning diffusion models using paired source and target images with matching anatomy can help. However, such paired data are very difficult and costly to obtain, and may also reduce the robustness of the developed model to out-of-distribution testing data. We propose a frequency-guided diffusion model (FGDM) that employs frequency-domain filters to guide the diffusion model for structure-preserving image translation. Based on its design, FGDM allows zero-shot learning, as it can be trained solely on the data from the target domain, and used directly for source-to-target domain translation without any exposure to the source-domain data during training. We evaluated it on three cone-beam CT (CBCT)-to-CT translation tasks for different anatomical sites, and a cross-institutional MR imaging translation task. FGDM outperformed the state-of-the-art methods (GAN-based, VAE-based, and diffusion-based) in metrics of Frechet Inception Distance (FID), Peak Signal-to-Noise Ratio (PSNR), and Structural Similarity Index Measure (SSIM), showing its significant advantages in zero-shot medical image translation

Domain Generalization for Medical Image Analysis: A Survey

Medical Image Analysis (MedIA) has become an essential tool in medicine and healthcare, aiding in disease diagnosis, prognosis, and treatment planning, and recent successes in deep learning (DL) have made significant contributions to its advances. However, DL models for MedIA remain challenging to deploy in real-world situations, failing for generalization under the distributional gap between training and testing samples, known as a distribution shift problem. Researchers have dedicated their efforts to developing various DL methods to adapt and perform robustly on unknown and out-of-distribution data distributions. This paper comprehensively reviews domain generalization studies specifically tailored for MedIA. We provide a holistic view of how domain generalization techniques interact within the broader MedIA system, going beyond methodologies to consider the operational implications on the entire MedIA workflow. Specifically, we categorize domain generalization methods into data-level, feature-level, model-level, and analysis-level methods. We show how those methods can be used in various stages of the MedIA workflow with DL equipped from data acquisition to model prediction and analysis. Furthermore, we include benchmark datasets and applications used to evaluate these approaches and analyze the strengths and weaknesses of various methods, unveiling future research opportunities

A unified formal framework for factorial and probabilistic topic modelling

Topic modelling has become a highly popular technique for extracting knowledge from texts. It encompasses various method families, including Factorial methods, Probabilistic methods, and Natural Language Processing methods. This paper introduces a unified conceptual framework for Factorial and Probabilistic methods by identifying shared elements and representing them using a homogeneous notation. The paper presents 12 different methods within this framework, enabling easy comparative analysis to assess the flexibility and how realistic the assumptions of each approach are. This establishes the initial stage of a broader analysis aimed at relating all method families to this common framework, comprehensively understanding their strengths and weaknesses, and establishing general application guidelines. Also, an experimental setup reinforces the convenience of having harmonized notational schema. The paper concludes with a discussion on the presented methods and outlines future research directions.Peer ReviewedPostprint (published version