Medicaid spending burden among beneficiaries with treatment-resistant depression.

AIM: To evaluate Medicaid spending and healthcare resource utilization (HRU) in treatment-resistant depression (TRD). MATERIALS & METHODS: TRD beneficiaries were identified from Medicaid claims databases (January 2010-March 2017) and matched 1:1 with major depressive disorder (MDD) beneficiaries without TRD (non-TRD-MDD) and randomly selected patients without MDD (non-MDD). Differences in HRU and per-patient-per-year costs were reported in incidence rate ratios (IRRs) and cost differences (CDs), respectively. RESULTS: TRD beneficiaries had higher HRU than 1:1 matched non-TRD-MDD (e.g., inpatient visits: IRR = 1.41) and non-MDD beneficiaries (N = 14,710 per cohort; e.g., inpatient visits: IRR = 3.42, p \u3c 0.01). TRD beneficiaries incurred greater costs versus non-TRD-MDD (CD = US$4382) and non-MDD beneficiaries (CD = US$8294; p \u3c 0.05). CONCLUSION: TRD is associated with higher HRU and costs versus non-TRD-MDD and non-MDD. TRD poses a significant burden to Medicaid

Countable dense homogeneity in powers of zero-dimensional definable spaces

We show that, for a coanalytic subspace $X$ of $2^\omega$, the countable dense homogeneity of $X^\omega$ is equivalent to $X$ being Polish. This strengthens a result of Hru\v{s}\'ak and Zamora Avil\'es. Then, inspired by results of Hern\'andez-Guti\'errez, Hru\v{s}\'ak and van Mill, using a technique of Medvedev, we construct a non-Polish subspace $X$ of $2^\omega$ such that $X^\omega$ is countable dense homogeneous. This gives the first $\mathsf{ZFC}$ answer to a question of Hru\v{s}\'ak and Zamora Avil\'es. Furthermore, since our example is consistently analytic, the equivalence result mentioned above is sharp. Our results also answer a question of Medini and Milovich. Finally, we show that if every countable subset of a zero-dimensional separable metrizable space $X$ is included in a Polish subspace of $X$ then $X^\omega$ is countable dense homogeneous.Comment: 14 page

SPATIAL PATTERN OF HYDROLOGIC RESPONSE UNIT (HRU) EFFECT ON FLOW DISCHARGE OF CI RASEA WATERSHED USING LANDSAT TM IN 1997 TO 2009

Hydrologic Response Unit (HRU) is a unit formed of hydrological analysis based on geology and soil type, slope, and land cover. This paper discussed the spatial pattern of Hydrologic Response Unit (HRU) in 1997-2009 and its impact on flow Ci Rasea watershed temporally. In this study, SWAT (Soil and Water Assessment Tool) model, based on land cover changed, was used to get HRU and flow in spatially and temporally. This method used Landsat TM 1997, 2003 and 2009 data for land cover and daily rainfall 1997-2009 for flow modeling. The results showed the spatial pattern of HRU in temporally was affected by landcover based on the changing of HRU. The majority of HRU spatial pattern at Ci Rasea watershed were clustered. During 1997-2009, accumulated surface runoff and the changing of flow discharge were affected by changes of HRU spatial pattern. The biggest accumulated surface runoff in Ci Rasea watershed influenced by HRU of agricultural cropland in area of clay soil type with slope slightly obliquely. While the smallest accumulated surface runoff in Ci Rasea watershed influenced by HRU of paddy field in the area of sandy loam soil type with a gentle slope. The changes of HRU agriculture cropland become HRU mixed cropland in area clay soil type with slope at a slight angle and HRU agriculture cropland become HRU paddy field in area, sandy loam soil type with a gentle slope could be decreasing the accumulation of surface runoff in Ci Rasea watershed

An observational study of pediatric healthcare burden in Angelman syndrome: results from a real-world study.

BACKGROUND:The objective of this study is to describe variations in the healthcare resource utilization (HRU) among individuals with Angelman syndrome (AS) over the first 12 years of life. Data for this study were drawn from the AS Natural History study (ASNHS), which is an observational study on the developmental progress, behavior, and medical morbidity of individuals with AS conducted over eight years. Caregiver-reported information on hospitalization, surgery, and medication utilization was used to assess HRU. Repeated measures mixed effect models were used to assess the relationship between age and probability of hospitalization, surgery, and prescription medication utilization. RESULTS:Mean age at study enrollment was 6 years of age and both sexes were equally represented. The mean number of visits per participant was three. Results from this study suggest that individuals with AS have a high HRU burden. Hospitalization and surgery burden were highest in the first year of life. Use of medications for seizures and sleep disturbance increased over time. CONCLUSIONS:The study highlights the significant healthcare burden among individuals with AS. Future studies that estimate cost and caregiver burden associated with AS are needed to assess the lifelong economic impact of AS on families and healthcare system

THE EFFECT OF HYDROLOGIC RESPONSE UNIT ON CI RASEA WATERSHED STREAMFLOW BASED ON LANDSAT TM

. This paper discusses spatial pattern of Hydrologic Response Unit (HRU), which is a unit formed of hydrological analysis, including geology and soil type, elevation and slope, and also land cover in 2009. This paper also discusses the impact of HRU on streamflow of Ci Rasea watershed, West Java. Ci Rasea watershed is located at the upstream part of Ci Tarum watersheds in West Java Province, Indonesia. This research used SWAT (Soil and Water Assessment Tool) model to obtain spatial HRU and river flow. The method used Landsat TM data for land cover and daily rainfall for river flow modeling. The results have shown spatial pattern of HRU which was affected by land cover, soil type and slope. In 2009, accumulated surface runoff and streamflow changes were spatially affected by HRU changes. The large amount accumulation of river flow discharge happened in HRU with landcover paddy field, silty clay soil, and flat slope. While the low discharge of river flow happened in HRU with plantation, clay soil, and slightly steep slopes as HRU dominant. It was found that accumulation of surface runoff in Ci Rasea watershed can be reduced by changing the land cover type in some areas with clay and slightly steep slope to become plantation area and the areas with sandy loam soil and flat slope can be used for paddy fields. Beside affected by HRU, the river flow discharge was also affected by the distance of sub watershed to the outlet. By using NS model and statistical t-student for calibration and validation, it was obtained that the accuracy of river flow models with HRU was 70%. It meant that the model could better simulate water flows of the Ci Rasea watershed

Checkers - like Network Game

Tato bakalářská práce se zabývá deskovou hrou dáma. Shrnuje její historii a hry, ze kterých se vyvinula do podoby, jakou známe dnes. Práce probírá jednotlivé verze pravidel, které se po světě hrají. Dále se zabývá rozborem algoritmů pro hru s počítačem. Výstupem bakalářské práce je program, který umožňuje hru dvou hráčů, síťovou hru a hru proti počítači při různém nastavení výchozích pravidel.This bachelor thesis is concerned with board game checkers. It summarizes the history and previous games. The thesis discusses the various versions of the rules that are played around the world. It also deals with the analysis of algorithms for a computer game. The result of this work is a program that allows the game two players, game via network and play against the computer. Also allows different setting default rules.