171,018 research outputs found

    Does international patent collaboration have an effect on entrepreneurship?

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    .Entrepreneurship is one of the main pillars of growth in any economy. Achieving a high rate of entrepreneurship in a region has become the priority objective of governments and firms. However, in many cases, new firm creation is conditioned by relations or collaboration in innovation with agents from other countries. Previous literature has analyzed the mechanisms that foster entrepreneurship. This paper attempts to shed light on the influence of international patent collaboration (IPC) on entrepreneurial activity at country level taking into account the timing of this relationship. An empirical study is proposed to verify whether IPC leads to greater entrepreneurship and to analyze the gestation period between international patenting actions and firm creation. Using the Generalized Method of Moments, the two hypotheses proposed were tested in a data panel of 30 countries for the period 2005‚Äď2017. Results show the influence of IPC in promoting entrepreneurship in the same year, but especially in the following year. The study offers implications for entrepreneurs and public agents. IPC affects the integration and interaction of international agents in a country, favors the production of new knowledge, and increases positive externalities in a territory. All this facilitates the creation of new companies with a high innovative component.S

    Application of lactic acid bacteria for the biopreservation of meat products: A systematic review

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    .The increasing concern of consumers about food quality and safety and their rejection of chemical additives has promoted the breakthrough of the biopreservation field and the development of studies on the use of beneficial bacteria and their metabolites as potential natural antimicrobials for shelf life extension and enhanced food safety. Control of foodborne pathogens in meat and meat products represents a serious challenge for the food industry which can be addressed through the intelligent use of bio-compounds or biopreservatives. This article aims to systematically review the available knowledge about biological strategies based on the use of lactic acid bacteria to control the proliferation of undesirable microorganisms in different meat products. The outcome of the literature search evidenced the potential of several strains of lactic acid bacteria and their purified or semi-purified antimicrobial metabolites as biopreservatives in meat products for achieving longer shelf life or inhibiting spoilage and pathogenic bacteria, especially when combined with other technologies to achieve a synergistic effect.S

    What is the importance of sperm subpopulations?

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    .The study of sperm subpopulations spans three decades. The origin, meaning, and practical significance, however, are less clear. Current technology for assessing sperm morphology (CASA-Morph) and motility (CASA-Mot) has enabled the accurate evaluation of these features, and there are many options for data classification. Subpopulations could occur as a result of the stage of development of each spermatozoon in the subpopulation. Spermatogenesis might contribute to the production of these subpopulations. Insights from evolutionary biology and recent molecular research are indicative of the diversity among male gametes that could occur from unequal sharing of transcripts and other elements through cytoplasmic bridges between spermatids. Sperm cohorts exiting the gonads would contain different RNA and protein contents, affecting the spermatozoon physiology and associations with the surrounding environmental milieu. Subsequently, these differences could affect how spermatozoa interact with the environmental milieu (maturation, mixing with seminal plasma, and interacting with the environmental milieu, or female genital tract and female gamete). The emergence of sperm subpopulations as an outcome of evolution, related to the reproductive strategies of the species, genital tract structures, and copulatory and fertilization processes. This kind of approach in determining the importance of sperm subpopulations in fertilization capacity should have a practical impact for conducting reproductive technologies, inspiring and enabling new ways for the more efficient use of spermatozoa in the medical, animal breeding, and conservation fields. This manuscript is a contribution to the Special Issue in memory of Dr. Duane GarnerS

    Las personas privadas de libertad sujetas a medios de control telemáticos la tecnología aplicada al trabajo social desde una perspectiva de derechos

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    Este manuscrito aborda el tratamiento de las personas privadas de libertad (en adelante PP) sujetas a sistemas de control telem√°tico, como medio alternativo al cumplimiento de la condena, as√≠ como respecto del papel que desempe√Īan los trabajadores y trabajadoras sociales en este escenario, mayormente en los Centros de Inserci√≥n Social (en adelante CIS). Por lo tanto, nuestros planteamientos de base se centran en el estudio del Sistema de Control Telem√°tico (en adelante SCT), as√≠ como en sustanciar los ‚Äúderechos y beneficios sociales‚ÄĚ que pueden dimanarse de la utilizaci√≥n de este recurso, teniendo en cuenta que, entre sus objetivos fundamentales, se encuentra el responder a necesidades sociales y humanas centradas en las circunstancias sanitarias, sociales, familiares y/o laborales de las PPL, permitiendo que √©stas se mantengan en su contexto social y comunitario, evitando con ello los problemas de desarraigo derivados de la institucionalizaci√≥n penitenciaria

    A new index of resilience applicable to external pulse-disturbances that considers the recovery of communities in the short term

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    .Resilience is a key concept in the study of the recovery of ecosystems affected by disturbances. Currently, there are numerous indices to measure resilience, but many of them do not show the accuracy of the resilience value or the behaviour of ecological parameters in the face of disturbances. New approaches and technologies enable large amounts of information to be obtained, facilitating the proposal of new resilience indices that work consistently and intuitively for a wide variety of ecological response variables under different scenarios after pulse-disturbances. In this study, we propose and verify a new resilience index, comparing its performance with others previously published. We validated the performance of the new index using real data based on field measurements of changes in soil bacterial OTUs diversity and abundance after a wildfire. The new resilience index provided an automatic and robust functional classification of the behaviour of ecosystems after disturbances, supported by a bootstrap analysis. We identified 5 scenarios of ecosystem resilience performance according to their behaviour after a pulse-disturbance: resilient, non-resilient, recovering, rebound, and continuing.S

    Calidad percibida del servicio en la cadena de aprovisionamiento en la industria turística

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    Este trabajo contribuye a relacionar las √°reas de la gesti√≥n de la calidad del servicio y la gesti√≥n de la cadena de aprovisionamiento. M√°s concretamente, permite comprender mejor c√≥mo la gesti√≥n de la calidad del servicio puede ayudar a describir, explicar y predecir los resultados en la cadena de aprovisionamiento. Se analizan qu√© factores son importantes considerar en la calidad percibida del servicio de la cadena de aprovisionamiento y c√≥mo influyen √©stos en la futura relaci√≥n comprador-proveedor. Para ello, se desarrolla y verifica un modelo incorporando constructos tales como desempe√Īo del servicio, calidad del servicio percibida, satisfacci√≥n y lealtad. La literatura aporta trabajos de estos constructor en la relaci√≥n empresa-cliente final y comprador-vendedor en empresas manufactureras, pero existe una laguna en la relaci√≥n entre miembros de de la cadena de aprovisionamiento en empresas de servicios. Por ello, el modelo fue verificado con 908 evaluaciones que realizaron los gerentes de establecimientos hoteleros sobre la calidad percibida del servicio del proveedor. El an√°lisis de los datos soporta el modelo conceptual donde la satisfacci√≥n y la lealtad de los gerentes de los hoteles al proveedor est√° muy influenciada por la calidad del servicio que recibe de √©ste

    Balancing the urban stomach: public health, food selling and consumption in London, c. 1558-1640

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    Until recently, public health histories have been predominantly shaped by medical and scientific perspectives, to the neglect of their wider social, economic and political contexts. These medically-minded studies have tended to present broad, sweeping narratives of health policy's explicit successes or failures, often focusing on extraordinary periods of epidemic disease viewed from a national context. This approach is problematic, particularly in studies of public health practice prior to 1800. Before the rise of modern scientific medicine, public health policies were more often influenced by shared social, cultural, economic and religious values which favoured maintaining hierarchy, stability and concern for 'the common good'. These values have frequently been overlooked by modern researchers. This has yielded pessimistic assessments of contemporary sanitation, implying that local authorities did not care about or prioritise the health of populations. Overly medicalised perspectives have further restricted historians' investigation and use of source material, their interpretation of multifaceted and sometimes contested cultural practices such as fasting, and their examination of habitual - and not just extraordinary - health actions. These perspectives have encouraged a focus on reactive - rather than preventative - measures. This thesis contributes to a growing body of research that expands our restrictive understandings of pre-modern public health. It focuses on how public health practices were regulated, monitored and expanded in later Tudor and early Stuart London, with a particular focus on consumption and food-selling. Acknowledging the fundamental public health value of maintaining urban foodways, it investigates how contemporaries sought to manage consumption, food production waste, and vending practices in the early modern City's wards and parishes. It delineates the practical and political distinctions between food and medicine, broadly investigates the activities, reputations of and correlations between London's guild and itinerant food vendors and licensed and irregular medical practitioners, traces the directions in which different kinds of public health policy filtered up or down, and explores how policies were enacted at a national and local level. Finally, it compares and contrasts habitual and extraordinary public health regulations, with a particular focus on how perceptions of and actual food shortages, paired with the omnipresent threat of disease, impacted broader aspects of civic life

    South Yorkshire low carbon energy supply chains: hydrogen sector summary

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    Bioinformatic characterization of a triacylglycerol lipase produced by Aspergillus flavus isolated from the decaying seed of Cucumeropsis mannii

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    Lipases are enzymes of industrial importance responsible for the hydrolysis of ester bonds of triglycerides. A lipolytic fungus was isolated and subsequently identified based on the ITS sequence analysis as putative Aspergillus flavus with accession number LC424503. The gene coding for extracellular triacylglycerol lipase was isolated from Aspergillus flavus species, sequenced, and characterised using bioinformatics tools. An open reading frame of 420 amino acid sequence was obtained and designated as Aspergillus flavus lipase (AFL) sequence. Alignment of the amino acid sequence with other lipases revealed the presence GHSLG sequence which is the lipase consensus sequence Gly-X1-Ser-X2-Gly indicating that it a classical lipase. A catalytic active site lid domain composed of TYITDTIIDLS amino acids sequence was also revealed. This lid protects the active site, control the catalytic activity and substrate selectivity in lipases. The 3-Dimensional structural model shared 34.08% sequence identity with a lipase from Yarrowia lipolytica covering 272 amino acid residues of the template model. A search of the lipase engineering database using AFL sequence revealed that it belongs to the class GX-lipase, superfamily abH23 and homologous family abH23.02, molecular weight and isoelectric point values of 46.95‚ÄČKDa and 5.7, respectively. N-glycosylation sites were predicted at residues 164, 236 and 333, with potentials of 0.7250, 0.7037 and 0.7048, respectively. O-glycosylation sites were predicted at residues 355, 358, 360 and 366. A signal sequence of 37 amino acids was revealed at the N-terminal of the polypeptide. This is a short peptide sequence that marks a protein for transport across the cell membrane and indicates that AFL is an extracellular lipase. The findings on the structural and molecular properties of Aspergillus flavus lipase in this work will be crucial in future studies aiming at engineering the enzyme for biotechnology applications

    Structural and Attitudinal Barriers to Bicycle Ownership and Cycle-Based Transport in Gauteng, South Africa

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    Policies that aim to facilitate and promote non-motorised transport (NMT), and in particular cycling, have been developed by many high-income countries facing increasingly congested roads and saturated public transport systems. Such policies are also emerging in many low- and middle-income settings where high rates of urbanisation have led to similar problems with motorised transport. The aim of the present study was to better understand the potential structural and attitudinal barriers to cycle-based transport in one such context: South Africa‚Äôs Gauteng Province, the industrial powerhouse of sub-Saharan Africa that has recently made a firm commitment to NMT. The study focussed on demographic and socioeconomic variation in bicycle and car ownership, and related this to: (1) the reported use of motorised and non-motorised transport (both private and public); and (2) perceived ‚Äėproblems‚Äô with cycling. The analyses drew on interviews with key respondents from n‚ÄČ=‚ÄČ27,490 households conducted in 2013 as part of the third Quality of Life survey undertaken by the Gauteng City Regional Observatory. The survey contained items on three outcomes of interest: household vehicle ownership (bicycles and cars); modes of transport used for the ‚Äútrips‚ÄĚ most often made; and respondents‚Äô ‚Äúsingle biggest problem with‚Ķ cycling‚ÄĚ. Respondent- and household-level demographic and socioeconomic determinants of these outcomes were examined using descriptive and multivariable statistical analyses, the latter after adjustment for measured potential confounders identified using a theoretical causal path diagram (in the form of a directed acyclic graph). Of the n‚ÄČ=‚ÄČ26,469 households providing complete data on all of the variables examined in the present study, only n‚ÄČ=‚ÄČ8722 (32.9%) owned a car and fewer still (n‚ÄČ=‚ÄČ2244; 8.4%) owned a bicycle. The ownership of these assets was commonest amongst wealthier, economically active households; and those that owned a car had over five times the odds of also owning a bicycle, even after adjustment for potential confounding (OR 5.17; 95% CI 4.58, 5.85). Moreover, of household respondents who reported making ‚Äėtrips‚Äô during the preceding month (n‚ÄČ=‚ÄČ18,209), over two-thirds of those whose households owned a car (70.1%) reported private car-based transport for such trips, while only 3.2% of those owning a bicycle reported cycling. Amongst the specific responses given to the item requesting the ‚Äúsingle biggest problem with‚Ķ cycling‚ÄĚ by far the commonest was ‚ÄúDon‚Äôt know how to cycle‚ÄĚ (32.2%), less than half as many citing ‚ÄúVehicle accident risk‚ÄĚ (15.9%), and fewer still: ‚ÄúDestination is too far‚ÄĚ (13.9%); ‚ÄúCrime‚ÄĚ (10.3%); ‚ÄúToo much effort‚ÄĚ (9.2%); or ‚ÄúLack of good paths‚ÄĚ (4.6%). While the first of these reasons was commonest amongst poorer households, concerns about risk and effort were both most common amongst better educated, economically active and wealthier/better serviced households. In contrast, concerns over (cycle) paths were only common amongst those owning bicycles. The low prevalence of household bicycle ownership, and the disproportionate number of households owning bicycles that also owned cars, might explain the very small proportion of the ‚Äėthe trips most often made‚Äô that involved cycle-based transport (0.3%), and the preferential use of cars amongst households owning both bicycles and cars. Low levels of bicycle ownership might also explain why so many respondents cited ‚ÄúDon‚Äôt know how‚ÄĚ as the ‚Äúsingle biggest problem with‚Ķ cycling‚ÄĚ; although risk and effort were also substantial concerns (presumably for many who did, and some who did not, know how to cycle); the lack of suitable cycle lanes being only primarily a concern for those who actually owned bicycles. Structural and attitudinal barriers to cycle-based transport limit the use of cycle-based transport in Gauteng, not only amongst the vast majority of household respondents who lack the means to cycle (and the means to learn how), but also amongst those dissuaded from learning to cycle, purchasing a bicycle and/or using a bicycle they own by: the risks and effort involved; the lack of suitable cycle paths; and/or because they also own a car and prefer to drive than cycle
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