Oncogenesis- kaleidoscopic and multi-level reality

Oncogenesis is an extremely complex phenomenon. The mechanisms by which cancer is induced is only partially known. Consequently, therapeutic targets may be uncertain and results are often unsatisfactory. The purpose of this paper is to develop a trans-level and multiple transdisciplinary perspective describing the kaleidoscopic reality of oncogenesis. This manner of understanding oncogenesis as a complex process characterized by a non-linear dynamic, far from equilibrium and with unpredictable evolution, transcends the classical perspective and requires a paradigm shift. This approach is also facilitated by recent studies that focus on group phenomena, with emerging behaviors in a continuous phase transition. Biological systems, and obviously the human organism, express this type of behavior with critical self-organizing valences in the context of a genome - mesotope (environment) - phenotype interaction. For example, nature has transposed in the ecosystem, among other things, the performance pattern of its mineral history represented by the dynamic energy-matter-information unit (the principle of invariance). And multi-cell biological systems in the phylogenetic tree crown have multiple directed aerobic metabolisms in accordance with specific functions. Cancers, in turn, have a hybrid (anaerobic and aerobic) and unidirectional metabolism whose only and ultimate reason is the survival of the malignant cell. Understanding the transdisciplinary reality of oncogenesis offers novel development paths for new therapeutic strategies compared to current ones which have relatively limited efficiency

Mechanics reveals the biological trigger in wrinkly fingers

The final publication is available at Springer via http://dx.doi.org/10.1007/s10439-016-1764-6Fingertips wrinkle due to long exposure to water. The biological reason for this morphological change is unclear and still not fully understood. There are two main hypotheses for the underlying mechanism of fingertip wrinkling: the ‘shrink’ model (in which the wrinkling is driven by the contraction of the lower layers of skin, associated with the shrinking of the underlying vasculature), and the ‘swell’ model (in which the wrinkling is driven by the swelling of the upper layers of the skin, associated with osmosis). In reality, contraction of the lower layers of the skin and swelling of the upper layers will happen simultaneously. However, the relative importance of these two mechanisms to drive fingertip wrinkling also remains unclear. Simulating the swelling in the upper layers of skin alone, which is associated with neurological disorders, we found that wrinkles appeared above an increase of volume of ˜10%.˜10%. Therefore, the upper layers can not exceed this swelling level in order to not contradict in vivo observations in patients with such neurological disorders. Simulating the contraction of the lower layers of the skin alone, we found that the volume have to decrease a ˜20%˜20% to observe wrinkles. Furthermore, we found that the combined effect of both mechanisms leads to pronounced wrinkles even at low levels of swelling and contraction when individually they do not. This latter results indicates that the collaborative effect of both hypothesis are needed to induce wrinkles in the fingertips. Our results demonstrate how models from continuum mechanics can be successfully applied to testing hypotheses for the mechanisms that underly fingertip wrinkling, and how these effects can be quantified.Peer ReviewedPostprint (published version

COMPARATIVE LAW AND THE PROCESS OF DE-JURIDIFICATION: THE JOINT-EMPLOYMENT LAW CASE IN LABOUR LAW

The process of de-juridification is, in some respects, ambiguous and paradoxical. While in certain areas, we see a proliferation of detailed legislative regulations, in others, we detect tendencies pointing in the opposite direction. One of the most interesting cases is that of labor law, where both tendencies emerge. Recent reforms in many European countries show a trend towards a relaxation of rules, inspired by the aim to stimulate growth in employment. In this context, the newly-introduced concept of \u201cjoint employment\u201d plays a pivotal role. The process of de-juridification clearly invests labor law, in particular within enterprise networks, where arrangements under joint employment seem to give the parties of a commercial contract the highest standard of contractual freedom. This social phenomenon is not therefore regulated by detailed legislative provisions, but simply through non-specific norms inspired by general goals. In considering several recent reforms of labor law in European countries, in this paper, we aim to determine the real level of de-juridification currently present within traditionally rigid legislative system

How Long can Left and Right Handed Life Forms Coexist?

Reaction-diffusion equations based on a polymerization model are solved to simulate the spreading of hypothetic left and right handed life forms on the Earth's surface. The equations exhibit front-like behavior as is familiar from the theory of the spreading of epidemics. It is shown that the relevant time scale for achieving global homochirality is not, however, the time scale of front propagation, but the much longer global diffusion time. The process can be sped up by turbulence and large scale flows. It is speculated that, if the deep layers of the early ocean were sufficiently quiescent, there may have been the possibility of competing early life forms with opposite handedness.Comment: submitted to Int. J. Astrobiol., 15 pages, 10 figs. submitted to Int. J. Astrobiol., 15 pages, 10 fig

Oscillatory secular modes: The thermal micropulses

Stars in the narrow mass range of about 2.5 and 3.5 solar masses can develop a thermally unstable He-burning shell during its ignition phase. We study, from the point of view secular stability theory, these so called thermal micropulses and we investigate their properties; the thermal pulses constitute a convenient conceptual laboratory to look thoroughly into the physical properties of a helium-burning shell during the whole thermally pulsing episode. Linear stability analyses were performed on a large number of 3 solar-mass star models at around the end of their core helium-burning and the beginning of the double-shell burning phase. The stellar models were not assumed to be in thermal equilibrium. The thermal mircopulses, and we conjecture all other thermal pulse episodes encountered by shell-burning stars, can be understood as the nonlinear finite-amplitude realization of an oscillatory secular instability that prevails during the whole thermal pulsing episode. Hence, the cyclic nature of the thermal pulses can be traced back to a linear instability concept.Comment: To be published - essentially footnote-free - in Astronomy & Astrophysic

Learning algorithms for adaptive digital filtering

In this thesis, we consider the problem of parameter optimisation in adaptive digital filtering. Adaptive digital filtering can be accomplished using both Finite Impulse Response (FIR) filters and Infinite Impulse Response Filters (IIR) filters. Adaptive FIR filtering algorithms are well established. However, the potential computational advantages of IIR filters has led to an increase in research on adaptive IIR filtering algorithms. These algorithms are studied in detail in this thesis and the limitations of current adaptive IIR filtering algorithms are identified. New approaches to adaptive IIR filtering using intelligent learning algorithms are proposed. These include Stochastic Learning Automata, Evolutionary Algorithms and Annealing Algorithms. Each of these techniques are used for the filtering problem and simulation results are presented showing the performance of the algorithms for adaptive IIR filtering. The relative merits and demerits of the different schemes are discussed. Two practical applications of adaptive IIR filtering are simulated and results of using the new adaptive strategies are presented. Other than the new approaches used, two new hybrid schemes are proposed based on concepts from genetic algorithms and annealing. It is shown with the help of simulation studies, that these hybrid schemes provide a superior performance to the exclusive use of any one scheme

JCMT POL-2 and ALMA polarimetric observations of 6000-100 au scales in the protostar B335: linking magnetic field and gas kinematics in observations and MHD simulations

We present our analysis of the magnetic field structures from 6000 au to 100 au scales in the Class 0 protostar B335 inferred from our JCMT POL-2 observations and the ALMA archival polarimetric data. To interpret the observational results, we perform a series of (non-)ideal MHD simulations of the collapse of a rotating non-turbulent dense core, whose initial conditions are adopted to be the same as observed in B335, and generate synthetic polarization maps. The comparison of our JCMT and simulation results suggests that the magnetic field on a 6000 au scale in B335 is pinched and well aligned with the bipolar outflow along the east-west direction. Among all our simulations, the ALMA polarimetric results are best explained with weak magnetic field models having an initial mass-to-flux ratio of 9.6. However, we find that with the weak magnetic field, the rotational velocity on a 100 au scale and the disk size in our simulations are larger than the observational estimates by a factor of several. An independent comparison of our simulations and the gas kinematics in B335 observed with the SMA and ALMA favors strong magnetic field models with an initial mass-to-flux ratio smaller than 4.8. We discuss two possibilities resulting in the different magnetic field strengths inferred from the polarimetric and molecular-line observations, (1) overestimated rotational-to-gravitational energy in B335 and (2) additional contributions in the polarized intensity due to scattering on a 100 au scale.Comment: Accepted by Ap