212 research outputs found
Graph edit distance from spectral seriation
This paper is concerned with computing graph edit distance. One of the criticisms that can be leveled at existing methods for computing graph edit distance is that they lack some of the formality and rigor of the computation of string edit distance. Hence, our aim is to convert graphs to string sequences so that string matching techniques can be used. To do this, we use a graph spectral seriation method to convert the adjacency matrix into a string or sequence order. We show how the serial ordering can be established using the leading eigenvector of the graph adjacency matrix. We pose the problem of graph-matching as a maximum a posteriori probability (MAP) alignment of the seriation sequences for pairs of graphs. This treatment leads to an expression in which the edit cost is the negative logarithm of the a posteriori sequence alignment probability. We compute the edit distance by finding the sequence of string edit operations which minimizes the cost of the path traversing the edit lattice. The edit costs are determined by the components of the leading eigenvectors of the adjacency matrix and by the edge densities of the graphs being matched. We demonstrate the utility of the edit distance on a number of graph clustering problems
A graph-spectral approach to shape-from-shading
In this paper, we explore how graph-spectral methods can be used to develop a new shape-from-shading algorithm. We characterize the field of surface normals using a weight matrix whose elements are computed from the sectional curvature between different image locations and penalize large changes in surface normal direction. Modeling the blocks of the weight matrix as distinct surface patches, we use a graph seriation method to find a surface integration path that maximizes the sum of curvature-dependent weights and that can be used for the purposes of height reconstruction. To smooth the reconstructed surface, we fit quadrics to the height data for each patch. The smoothed surface normal directions are updated ensuring compliance with Lambert's law. The processes of height recovery and surface normal adjustment are interleaved and iterated until a stable surface is obtained. We provide results on synthetic and real-world imagery
Toward a multilevel representation of protein molecules: comparative approaches to the aggregation/folding propensity problem
This paper builds upon the fundamental work of Niwa et al. [34], which
provides the unique possibility to analyze the relative aggregation/folding
propensity of the elements of the entire Escherichia coli (E. coli) proteome in
a cell-free standardized microenvironment. The hardness of the problem comes
from the superposition between the driving forces of intra- and inter-molecule
interactions and it is mirrored by the evidences of shift from folding to
aggregation phenotypes by single-point mutations [10]. Here we apply several
state-of-the-art classification methods coming from the field of structural
pattern recognition, with the aim to compare different representations of the
same proteins gathered from the Niwa et al. data base; such representations
include sequences and labeled (contact) graphs enriched with chemico-physical
attributes. By this comparison, we are able to identify also some interesting
general properties of proteins. Notably, (i) we suggest a threshold around 250
residues discriminating "easily foldable" from "hardly foldable" molecules
consistent with other independent experiments, and (ii) we highlight the
relevance of contact graph spectra for folding behavior discrimination and
characterization of the E. coli solubility data. The soundness of the
experimental results presented in this paper is proved by the statistically
relevant relationships discovered among the chemico-physical description of
proteins and the developed cost matrix of substitution used in the various
discrimination systems.Comment: 17 pages, 3 figures, 46 reference
Convex Relaxations for Permutation Problems
Seriation seeks to reconstruct a linear order between variables using
unsorted, pairwise similarity information. It has direct applications in
archeology and shotgun gene sequencing for example. We write seriation as an
optimization problem by proving the equivalence between the seriation and
combinatorial 2-SUM problems on similarity matrices (2-SUM is a quadratic
minimization problem over permutations). The seriation problem can be solved
exactly by a spectral algorithm in the noiseless case and we derive several
convex relaxations for 2-SUM to improve the robustness of seriation solutions
in noisy settings. These convex relaxations also allow us to impose structural
constraints on the solution, hence solve semi-supervised seriation problems. We
derive new approximation bounds for some of these relaxations and present
numerical experiments on archeological data, Markov chains and DNA assembly
from shotgun gene sequencing data.Comment: Final journal version, a few typos and references fixe
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