8,858 research outputs found
Connecting the Dots: Towards Continuous Time Hamiltonian Monte Carlo
Continuous time Hamiltonian Monte Carlo is introduced, as a powerful
alternative to Markov chain Monte Carlo methods for continuous target
distributions. The method is constructed in two steps: First Hamiltonian
dynamics are chosen as the deterministic dynamics in a continuous time
piecewise deterministic Markov process. Under very mild restrictions, such a
process will have the desired target distribution as an invariant distribution.
Secondly, the numerical implementation of such processes, based on adaptive
numerical integration of second order ordinary differential equations is
considered. The numerical implementation yields an approximate, yet highly
robust algorithm that, unlike conventional Hamiltonian Monte Carlo, enables the
exploitation of the complete Hamiltonian trajectories (hence the title). The
proposed algorithm may yield large speedups and improvements in stability
relative to relevant benchmarks, while incurring numerical errors that are
negligible relative to the overall Monte Carlo errors
Techniques for the Fast Simulation of Models of Highly dependable Systems
With the ever-increasing complexity and requirements of highly dependable systems, their evaluation during design and operation is becoming more crucial. Realistic models of such systems are often not amenable to analysis using conventional analytic or numerical methods. Therefore, analysts and designers turn to simulation to evaluate these models. However, accurate estimation of dependability measures of these models requires that the simulation frequently observes system failures, which are rare events in highly dependable systems. This renders ordinary Simulation impractical for evaluating such systems. To overcome this problem, simulation techniques based on importance sampling have been developed, and are very effective in certain settings. When importance sampling works well, simulation run lengths can be reduced by several orders of magnitude when estimating transient as well as steady-state dependability measures. This paper reviews some of the importance-sampling techniques that have been developed in recent years to estimate dependability measures efficiently in Markov and nonMarkov models of highly dependable system
Patterns of Scalable Bayesian Inference
Datasets are growing not just in size but in complexity, creating a demand
for rich models and quantification of uncertainty. Bayesian methods are an
excellent fit for this demand, but scaling Bayesian inference is a challenge.
In response to this challenge, there has been considerable recent work based on
varying assumptions about model structure, underlying computational resources,
and the importance of asymptotic correctness. As a result, there is a zoo of
ideas with few clear overarching principles.
In this paper, we seek to identify unifying principles, patterns, and
intuitions for scaling Bayesian inference. We review existing work on utilizing
modern computing resources with both MCMC and variational approximation
techniques. From this taxonomy of ideas, we characterize the general principles
that have proven successful for designing scalable inference procedures and
comment on the path forward
A relative entropy rate method for path space sensitivity analysis of stationary complex stochastic dynamics
We propose a new sensitivity analysis methodology for complex stochastic
dynamics based on the Relative Entropy Rate. The method becomes computationally
feasible at the stationary regime of the process and involves the calculation
of suitable observables in path space for the Relative Entropy Rate and the
corresponding Fisher Information Matrix. The stationary regime is crucial for
stochastic dynamics and here allows us to address the sensitivity analysis of
complex systems, including examples of processes with complex landscapes that
exhibit metastability, non-reversible systems from a statistical mechanics
perspective, and high-dimensional, spatially distributed models. All these
systems exhibit, typically non-gaussian stationary probability distributions,
while in the case of high-dimensionality, histograms are impossible to
construct directly. Our proposed methods bypass these challenges relying on the
direct Monte Carlo simulation of rigorously derived observables for the
Relative Entropy Rate and Fisher Information in path space rather than on the
stationary probability distribution itself. We demonstrate the capabilities of
the proposed methodology by focusing here on two classes of problems: (a)
Langevin particle systems with either reversible (gradient) or non-reversible
(non-gradient) forcing, highlighting the ability of the method to carry out
sensitivity analysis in non-equilibrium systems; and, (b) spatially extended
Kinetic Monte Carlo models, showing that the method can handle high-dimensional
problems
Hybrid Pathwise Sensitivity Methods for Discrete Stochastic Models of Chemical Reaction Systems
Stochastic models are often used to help understand the behavior of
intracellular biochemical processes. The most common such models are continuous
time Markov chains (CTMCs). Parametric sensitivities, which are derivatives of
expectations of model output quantities with respect to model parameters, are
useful in this setting for a variety of applications. In this paper, we
introduce a class of hybrid pathwise differentiation methods for the numerical
estimation of parametric sensitivities. The new hybrid methods combine elements
from the three main classes of procedures for sensitivity estimation, and have
a number of desirable qualities. First, the new methods are unbiased for a
broad class of problems. Second, the methods are applicable to nearly any
physically relevant biochemical CTMC model. Third, and as we demonstrate on
several numerical examples, the new methods are quite efficient, particularly
if one wishes to estimate the full gradient of parametric sensitivities. The
methods are rather intuitive and utilize the multilevel Monte Carlo philosophy
of splitting an expectation into separate parts and handling each in an
efficient manner.Comment: 30 pages. The numerical example section has been extensively
rewritte
- …