33,529 research outputs found
A synthesis of logic and bio-inspired techniques in the design of dependable systems
Much of the development of model-based design and dependability analysis in the design of dependable systems, including software intensive systems, can be attributed to the application of advances in formal logic and its application to fault forecasting and verification of systems. In parallel, work on bio-inspired technologies has shown potential for the evolutionary design of engineering systems via automated exploration of potentially large design spaces. We have not yet seen the emergence of a design paradigm that effectively combines these two techniques, schematically founded on the two pillars of formal logic and biology, from the early stages of, and throughout, the design lifecycle. Such a design paradigm would apply these techniques synergistically and systematically to enable optimal refinement of new designs which can be driven effectively by dependability requirements. The paper sketches such a model-centric paradigm for the design of dependable systems, presented in the scope of the HiP-HOPS tool and technique, that brings these technologies together to realise their combined potential benefits. The paper begins by identifying current challenges in model-based safety assessment and then overviews the use of meta-heuristics at various stages of the design lifecycle covering topics that span from allocation of dependability requirements, through dependability analysis, to multi-objective optimisation of system architectures and maintenance schedules
Synthetic biology and microdevices : a powerful combination
Recent developments demonstrate that the combination of microbiology with micro-and nanoelectronics is a successful approach to develop new miniaturized sensing devices and other technologies. In the last decade, there has been a shift from the optimization of the abiotic components, for example, the chip, to the improvement of the processing capabilities of cells through genetic engineering. The synthetic biology approach will not only give rise to systems with new functionalities, but will also improve the robustness and speed of their response towards applied signals. To this end, the development of new genetic circuits has to be guided by computational design methods that enable to tune and optimize the circuit response. As the successful design of genetic circuits is highly dependent on the quality and reliability of its composing elements, intense characterization of standard biological parts will be crucial for an efficient rational design process in the development of new genetic circuits. Microengineered devices can thereby offer a new analytical approach for the study of complex biological parts and systems. By summarizing the recent techniques in creating new synthetic circuits and in integrating biology with microdevices, this review aims at emphasizing the power of combining synthetic biology with microfluidics and microelectronics
Automated Fixing of Programs with Contracts
This paper describes AutoFix, an automatic debugging technique that can fix
faults in general-purpose software. To provide high-quality fix suggestions and
to enable automation of the whole debugging process, AutoFix relies on the
presence of simple specification elements in the form of contracts (such as
pre- and postconditions). Using contracts enhances the precision of dynamic
analysis techniques for fault detection and localization, and for validating
fixes. The only required user input to the AutoFix supporting tool is then a
faulty program annotated with contracts; the tool produces a collection of
validated fixes for the fault ranked according to an estimate of their
suitability.
In an extensive experimental evaluation, we applied AutoFix to over 200
faults in four code bases of different maturity and quality (of implementation
and of contracts). AutoFix successfully fixed 42% of the faults, producing, in
the majority of cases, corrections of quality comparable to those competent
programmers would write; the used computational resources were modest, with an
average time per fix below 20 minutes on commodity hardware. These figures
compare favorably to the state of the art in automated program fixing, and
demonstrate that the AutoFix approach is successfully applicable to reduce the
debugging burden in real-world scenarios.Comment: Minor changes after proofreadin
"Going back to our roots": second generation biocomputing
Researchers in the field of biocomputing have, for many years, successfully
"harvested and exploited" the natural world for inspiration in developing
systems that are robust, adaptable and capable of generating novel and even
"creative" solutions to human-defined problems. However, in this position paper
we argue that the time has now come for a reassessment of how we exploit
biology to generate new computational systems. Previous solutions (the "first
generation" of biocomputing techniques), whilst reasonably effective, are crude
analogues of actual biological systems. We believe that a new, inherently
inter-disciplinary approach is needed for the development of the emerging
"second generation" of bio-inspired methods. This new modus operandi will
require much closer interaction between the engineering and life sciences
communities, as well as a bidirectional flow of concepts, applications and
expertise. We support our argument by examining, in this new light, three
existing areas of biocomputing (genetic programming, artificial immune systems
and evolvable hardware), as well as an emerging area (natural genetic
engineering) which may provide useful pointers as to the way forward.Comment: Submitted to the International Journal of Unconventional Computin
A synthesis of logic and biology in the design of dependable systems
The technologies of model-based design and dependability analysis in the design of dependable systems, including software intensive systems, have advanced in recent years. Much of this development can be attributed to the application of advances in formal logic and its application to fault forecasting and verification of systems. In parallel, work on bio-inspired technologies has shown potential for the evolutionary design of engineering systems via automated exploration of potentially large design spaces. We have not yet seen the emergence of a design paradigm that combines effectively and throughout the design lifecycle these two techniques which are schematically founded on the two pillars of formal logic and biology. Such a design paradigm would apply these techniques synergistically and systematically from the early stages of design to enable optimal refinement of new designs which can be driven effectively by dependability requirements. The paper sketches such a model-centric paradigm for the design of dependable systems that brings these technologies together to realise their combined potential benefits
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