13,243 research outputs found
Robust Temporally Coherent Laplacian Protrusion Segmentation of 3D Articulated Bodies
In motion analysis and understanding it is important to be able to fit a
suitable model or structure to the temporal series of observed data, in order
to describe motion patterns in a compact way, and to discriminate between them.
In an unsupervised context, i.e., no prior model of the moving object(s) is
available, such a structure has to be learned from the data in a bottom-up
fashion. In recent times, volumetric approaches in which the motion is captured
from a number of cameras and a voxel-set representation of the body is built
from the camera views, have gained ground due to attractive features such as
inherent view-invariance and robustness to occlusions. Automatic, unsupervised
segmentation of moving bodies along entire sequences, in a temporally-coherent
and robust way, has the potential to provide a means of constructing a
bottom-up model of the moving body, and track motion cues that may be later
exploited for motion classification. Spectral methods such as locally linear
embedding (LLE) can be useful in this context, as they preserve "protrusions",
i.e., high-curvature regions of the 3D volume, of articulated shapes, while
improving their separation in a lower dimensional space, making them in this
way easier to cluster. In this paper we therefore propose a spectral approach
to unsupervised and temporally-coherent body-protrusion segmentation along time
sequences. Volumetric shapes are clustered in an embedding space, clusters are
propagated in time to ensure coherence, and merged or split to accommodate
changes in the body's topology. Experiments on both synthetic and real
sequences of dense voxel-set data are shown. This supports the ability of the
proposed method to cluster body-parts consistently over time in a totally
unsupervised fashion, its robustness to sampling density and shape quality, and
its potential for bottom-up model constructionComment: 31 pages, 26 figure
Identifying Ligand Binding Conformations of the β2-Adrenergic Receptor by Using Its Agonists as Computational Probes
Recently available G-protein coupled receptor (GPCR) structures and biophysical studies suggest that the difference between the effects of various agonists and antagonists cannot be explained by single structures alone, but rather that the conformational ensembles of the proteins need to be considered. Here we use an elastic network model-guided molecular dynamics simulation protocol to generate an ensemble of conformers of a prototypical GPCR, β2-adrenergic receptor (β2AR). The resulting conformers are clustered into groups based on the conformations of the ligand binding site, and distinct conformers from each group are assessed for their binding to known agonists of β2AR. We show that the select ligands bind preferentially to different predicted conformers of β2AR, and identify a role of β2AR extracellular region as an allosteric binding site for larger drugs such as salmeterol. Thus, drugs and ligands can be used as "computational probes" to systematically identify protein conformers with likely biological significance. © 2012 Isin et al
Data-Driven Shape Analysis and Processing
Data-driven methods play an increasingly important role in discovering
geometric, structural, and semantic relationships between 3D shapes in
collections, and applying this analysis to support intelligent modeling,
editing, and visualization of geometric data. In contrast to traditional
approaches, a key feature of data-driven approaches is that they aggregate
information from a collection of shapes to improve the analysis and processing
of individual shapes. In addition, they are able to learn models that reason
about properties and relationships of shapes without relying on hard-coded
rules or explicitly programmed instructions. We provide an overview of the main
concepts and components of these techniques, and discuss their application to
shape classification, segmentation, matching, reconstruction, modeling and
exploration, as well as scene analysis and synthesis, through reviewing the
literature and relating the existing works with both qualitative and numerical
comparisons. We conclude our report with ideas that can inspire future research
in data-driven shape analysis and processing.Comment: 10 pages, 19 figure
Taming a non-convex landscape with dynamical long-range order: memcomputing Ising benchmarks
Recent work on quantum annealing has emphasized the role of collective
behavior in solving optimization problems. By enabling transitions of clusters
of variables, such solvers are able to navigate their state space and locate
solutions more efficiently despite having only local connections between
elements. However, collective behavior is not exclusive to quantum annealers,
and classical solvers that display collective dynamics should also possess an
advantage in navigating a non-convex landscape. Here, we give evidence that a
benchmark derived from quantum annealing studies is solvable in polynomial time
using digital memcomputing machines, which utilize a collection of dynamical
components with memory to represent the structure of the underlying
optimization problem. To illustrate the role of memory and clarify the
structure of these solvers we propose a simple model of these machines that
demonstrates the emergence of long-range order. This model, when applied to
finding the ground state of the Ising frustrated-loop benchmarks, undergoes a
transient phase of avalanches which can span the entire lattice and
demonstrates a connection between long-range behavior and their probability of
success. These results establish the advantages of computational approaches
based on collective dynamics of continuous dynamical systems
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