A lean man with nonalcoholic fatty liver disease

ArticleCLINICAL GASTROENTEROLOGY AND HEPATOLOGY. 5(3): XXXII (2007)journal articl

Hepatitis C Virus, Splenic Vein Thrombosis, and Lymphoma

ArticleCLINICAL GASTROENTEROLOGY AND HEPATOLOGY 7(2): 24(2009)journal articl

Hepatitis B virus core and core-related antigen quantitation in Chinese patients with chronic genotype B and C hepatitis B virus infection

The definitive version is available at www.blackwell-synergy.com.ArticleJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. 20(11): 1726-1730 (2005)journal articl

Hepatitis B virus core and core-related antigen quantitation in Chinese patients with chronic genotype B and C hepatitis B virus infection

The definitive version is available at www.blackwell-synergy.com.ArticleJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY. 20(11): 1726-1730 (2005)journal articl

Gastroenterology and Hepatology Experts\u27 Views about the Current Information Retrieval Systems and Determining the Characteristics of the Optimal System from Their Point of View

Objective: The ideal goal of any information system is to supply and deliver the information that users need. The aim of this study is to determine gastroenterology and hepatology experts\u27 views about the current information retrieval systems and determining the characteristics of the optimal system from their point of view. Methods: This is qualitative research that has been done phenomenologically. The study population 14 gastroenterology and hepatology experts. The data collection tool was a free interview in a non-structured way. Colaizzi\u27s descriptive phenomenological method was used to collect data. Results: The problems were classified into 3 categories, 15 general themes, and 31 sub-themes. The optimal information retrieval systems were classified into 4 categories, 12 general themes, and 41 sub-themes. Conclusions: The success of information retrieval systems, especially in the field of medical sciences, depends on considering various dimensions that not paying attention to them can lead to dissatisfaction of end-users of the system and ultimately the failure of the retrieval system. Therefore, it is suggested that information retrieval system design be done by developers under the characteristics of the optimal information retrieval system by gastroenterology and hepatology expert

Evaluation of rapid diagnostic tests for assessment of hepatitis B in resource-limited settings

Chronic Hepatitis B (HBV) is the most important cause of liver disease worldwide. There is a need for low-cost tests to aid in diagnosis and management of HBV infection in resource-limited settings. We evaluated the utility of several rapid diagnostic tests (RDT) in three different continents (Europe, South America, Africa). The HBsAg RDT showed optimal sensitivity and specificity. The anti-HBeAb RDT showed acceptable sensitivity and excellent specificity. Our results suggest that these RDTs could be used for screening and management of HBV.Fil: Leathers, James S.. Uc Davis School Of Medicine; Estados UnidosFil: Pisano, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; ArgentinaFil: Ré, Viviana Elizabeth. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología Dr. J. M. Vanella; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Van Oord, Gertine. Erasmus MC. Department of Gastroenterology and Hepatology; Países BajosFil: Sultan, Amir. Addis Ababa University; EtiopíaFil: Boonstra, Andre. Erasmus MC. Department of Gastroenterology and Hepatology; Países BajosFil: Debes, Jose D.. University of Minnesota; Estados Unidos. Erasmus MC. Department of Gastroenterology and Hepatology; Países Bajo

Functional bowel disease : a challenging frontier in gastroenterology

The last 30 years have seen incredible advances in the science and practice of gastroenterology and hepatology. In the 1970s, the fiberoptic endoscopic revolution facilitated the visualization of the mucosa of a large segment of the gastrointestinal tract and afforded the opportunity for specialized studies using histological and biochemical analyses. The impact of fiberoptic endoscopy on surveillance or screening for cancer of the colon will be more apparent in the next millennium. Novel pharmacological approaches have had a dramatic impact on gastroenterology.peer-reviewe

Conceptual framework of information retrieval system in the field of gastroenterology and hepatology

Background and aims: Optimal information retrieval is one of the components of achieving evidence-based medicine. This study aimed to present the Conceptual framework of information retrieval system in the field of Gastroenterology and hepatology. Methods: Based on the previous two studies, the characteristics of the optimal information retrieval system from the perspective of gastroenterologists and hepatologists and the most important approaches and technologies used in the design of information retrieval systems in medical sciences have been used in designing the proposed conceptual framework. Results: The conceptual framework of the information retrieval system in the gastroenterology and hepatology was presented in 4 sections and the technical and content features were presented in each section. Conclusions: Considering the comparison of this research with other researches in the field of frameworks and conceptual models of retrieval systems, special needs of users and using methods of personalization of information as well as conceptual mapping of resources have been the most important differences with other researches

Animal models of NASH: getting both pathology and metabolic context right

Non-alcoholic fatty liver disease (NAFLD) is the most common cause of referral to liver clinics, and its progressive form, non-alcoholic steatohepatitis (NASH), can lead to cirrhosis and end-stage liver disease. The main risk factors for NAFLD/NASH are the metabolic abnormalities commonly observed in metabolic syndrome: insulin resistance, visceral obesity, dyslipidemia and altered adipokine profile. At present, the causes of progression from NAFLD to NASH remain poorly defined, and research in this area has been limited by the availability of suitable animal models of this disease. In the past, the main models used to investigate the pathogenesis of steatohepatitis have either failed to reproduce the full spectrum of liver pathology that characterizes human NASH, or the liver pathology has developed in a metabolic context that is not representative of the human condition. In the last few years, a number of models have been described in which the full spectrum of liver pathology develops in an appropriate metabolic context. In general, the underlying cause of metabolic defects in these models is chronic caloric overconsumption, also known as overnutrition. Overnutrition has been achieved in a number of different ways, including forced feeding, administration of high-fat diets, the use of genetically hyperphagic animals, or a combination of these approaches. The purpose of the present review is to critique the liver pathology and metabolic abnormalities present in currently available animal models of NASH, with particular focus on models described in approximately the last 5 years.This research was funded through a grant. - Research in the authors' laboratory is supported by program grant 358398 from the Australian National Health and Medical Research Council (NHMRC)