Enhanced co-solubilities of Ca and Si in YAG (Y3Al5O12)

General garnet structure (Ia3-d) is a forgiving host and can accommodate cations of varying sizes and valence states. Studies on highly yttrium doped alumina ceramics with Ca and Si contamination indicated that YAG precipitates in the ceramic had a propensity to allow simultaneous incorporation of small amounts of Ca and Si impurities in their structure. In this study, using chemical synthesis techniques it was shown that YAG can accommodate up to approximately 8 cation % Ca+2 and Si+4 (i.e. Ca+2/Y+3 and Si+4/Y+3) if they are incorporated together. Equilibrium conditions are established by calcining samples at 900 C for 2 hours and cooling the samples to room temperature in the furnace. Disappearing-phase method and energy dispersive X-ray spectroscopy (EDS) were used to determine solubility and co-solubility limits. Beyond the solubility limit phase separation occurred and three crystalline yttrium aluminate phases (YAG, YAP (yttrium aluminate perovskite, YAlO3), YAM (yttrium aluminate monoclinic, Y4Al2O9)) were observed. It is believed that the excess Ca and Si above co-solubility limit precipitate out in the form of an x-ray amorphous anorthite-like glass in the system

Scientists in the MIST: Simplifying Interface Design for End Users

We are building a Malleable Interactive Software Toolkit (MIST), a tool set and infrastructure to simplify the design and construction of dynamically-reconfigurable (malleable) interactive software. Malleable software offers the end-user powerful tools to reshape their interactive environment on the fly. We aim to make the construction of such software straightforward, and to make reconfiguration of the resulting systems approachable and manageable to an educated, but non-specialist, user. To do so, we draw on a diverse body of existing research on alternative approaches to user interface (UI) and interactive software construction, including declarative UI languages, constraint-based programming and UI management, reflection and data-driven programming, and visual programming techniques

Metamorphic and metasomatic evolution of the Western Domain of the Karagwe-Ankole Belt (Central Africa)

The tectonometamorphic evolution of the Western Domain of the Karagwe-Ankole Belt, containing widespread granite-related W-Nb-Ta-Sn mineralization in pegmatites and hydrothermal quartz veins of Early Neoproterozoic age, is largely unknown. This study aims to characterize the Meso- and Neoproterozoic metamorphism and metasomatism in the Karagwe-Ankole Belt, to reconstruct the temperature evolution and to investigate its temporal relation to deformation and the widespread granite magmatism and mineralization. A quantitative geothermometric study was conducted on metasiltstones and amphibolites, and applies thin section petrography, garnet-biotite and chlorite geothermometry on samples collected in the representative KibuyeGitarama-Gatumba area in West Rwanda. The presence of garnet, staurolite and kyanite in metasiltstones, and hornblende and andesine-labradorite feldspar in amphibolites indicates prograde Barrovian metamorphism up to syn-to post-deformational (D1 or D2) lower amphibolite facies (up to 630 degrees C). This peak metamorphism was followed by post-D2 greenschist facies metamorphism (c. 525 degrees C-440 degrees C; garnet, biotite, chlorite, muscovite in metasiltstone), probably related to the East African Orogeny as part of the Gondwana assembly. A geothermometric evolution with high temperature conditions ( > 500 degrees C) at least from the flare-up of Early Neoproterozoic tin granites and their metasomatic haloes onwards for most of the Neoproterozoic is proposed, in close correspondence with the geodynamic evolution of the neighboring terranes. Additionally, this high temperature regime is an important factor to be taken into account when interpreting thermal diffusion-sensitive geochronological data

Update on the Nonprofit Sustainability Initiative

The hope is that the NSI will help to further normalize the dialogue and activity around mergers and collaborations in the sector. The NSI's definition of success is: "By the end of the active NSI effort, Strategic Restructuring will be normalized in LA County's nonprofit ecosystem. This ecosystem understands, supports, and engages in SR as a tool for enhanced impact and sustainability." Part of the NSI's measure of success is whether we have helped to create an environment where nonprofits are more comfortable discussing strategic partnerships with their boards and with funders, where funders are more receptive to funding this type of work, and nonprofits have the tools and professional support needed to effectively engage in the work. The funders and the evaluation team believe that attitudes and perceptions around mergers and strategic partnerships within the local nonprofit and philanthropic sector have begun to shift since the launch of the initiative. However, the funders also recognize that beyond the life of the NSI, there may continue to be a need for education in the sector on the range of strategic partnership possibilities as well as training for consultants on facilitation of strategic restructuring and partnership work. Discussions are taking place among the funders now around what entity/entities might be best to carry that work forward.This project has brought together funders and nonprofits in Los Angeles to focus on long-term sustainability issues in the nonprofit sector in a systematic way. The NSI continues to garner attention from nonprofits and funders throughout the country and is already being looked at as a model to support strategic restructuring within the nonprofitsector

Epithelial ingrowth following laser in situ keratomileusis (LASIK): prevalence, risk factors, management and visual outcomes

The number of laser in situ keratomileusis (LASIK) procedures is continuing to rise. Since its first application for correcting simple refractive errors over 25 years ago, the role of LASIK has extended to treat other conditions, including postkeratoplasty astigmatism/ametropia, postcataract surgery refractive error and presbyopia, among others. The long-term effectiveness, predictability and safety have been well established by many large studies. However, due to the creation of a potential interface between the flap and the underlying stroma, interface complications such as infectious keratitis, diffuse lamellar keratitis and epithelial ingrowth may occur. Post-LASIK epithelial ingrowth (PLEI) is an uncommon complication that usually arises during the early postoperative period. The reported incidence of PLEI ranged from 0%–3.9% in primary treatment to 10%–20% in retreatment cases. It can cause a wide spectrum of clinical presentations, ranging from asymptomatic interface changes to severe visual impairment and flap melt requiring keratoplasty. PLEI can usually be treated with mechanical debridement of the affected interface; however, additional interventions, such as alcohol, mitomycin C, fibrin glue, ocular hydrogel sealant, neodymium:yttriumaluminum garnet laser and amniotic membrane graft, may be required for recurrent or refractory cases. The aims of this review are to determine the prevalence and risk factors of PLEI; to describe its pathogenesis and clinical features and to summarise the therapeutic armamentarium and the visual outcome of PLEI

The North Star and the Atlantic 1848

This article explores the coverage of the 1848 uprisings in Europe by the North Star, a black newspaper edited by Frederick Douglass

Laser augmented by brachytherapy versus laser alone in the palliation of adenocarcinoma of the oesophagus and cardia: a randomised study

Background: Many patients with advanced malignant dysphagia are not suitable for definitive treatment. The best option for palliation of dysphagia varies between patients. This paper looks at a simple technique for enhancing laser recanalisation. Aim: To assess the value of adjunctive brachytherapy in prolonging palliation of malignant dysphagia by endoscopic laser therapy. Patients: Twenty two patients with advanced malignant dysphagia due to adenocarcinoma of the oesophagus or gastric cardia, unsuitable for surgery or radical chemoradiotherapy. Methods: Patients able to eat a soft diet after laser recanalisation were randomised to no further therapy or a single treatment with brachytherapy (10 Gy). Results were judged on the quality and duration of dysphagia palliation, need for subsequent intervention, complications, and survival. Results: The median dysphagia score for all patients two weeks after initial treatment was 1 (some solids). The median dysphagia palliated interval from the end of initial treatment to recurrent dysphagia or death increased from five weeks (control group) to 19 weeks (brachytherapy group). Three patients had some odynophagia for up to six weeks after brachytherapy. There was no other treatment related morbidity or mortality. Further intervention was required in 10 of 11 control patients (median five further procedures) compared with 7/11 brachytherapy patients (median two further procedures). There was no difference in survival (median 20 weeks (control), 26 weeks (brachytherapy)). Conclusions: Laser therapy followed by brachytherapy is a safe, straightforward, and effective option for palliating advanced malignant dysphagia, which is complementary to stent insertion