Multiplex giant magnetoresistive biosensor microarrays identify interferon-associated autoantibodies in systemic lupus erythematosus.

High titer, class-switched autoantibodies are a hallmark of systemic lupus erythematosus (SLE). Dysregulation of the interferon (IFN) pathway is observed in individuals with active SLE, although the association of specific autoantibodies with chemokine score, a combined measurement of three IFN-regulated chemokines, is not known. To identify autoantibodies associated with chemokine score, we developed giant magnetoresistive (GMR) biosensor microarrays, which allow the parallel measurement of multiple serum antibodies to autoantigens and peptides. We used the microarrays to analyze serum samples from SLE patients and found individuals with high chemokine scores had significantly greater reactivity to 13 autoantigens than individuals with low chemokine scores. Our findings demonstrate that multiple autoantibodies, including antibodies to U1-70K and modified histone H2B tails, are associated with IFN dysregulation in SLE. Further, they show the microarrays are capable of identifying autoantibodies associated with relevant clinical manifestations of SLE, with potential for use as biomarkers in clinical practice

Magnon-polaron and Spin-polaron Signatures in the Specific Heat and Electrical Resistivity of La0.6Y0.1Ca0.3MnO3La_{0.6}Y_{0.1}Ca_{0.3}MnO_3 in Zero Magnetic Field, and the Effect of Mn−O−MnMn-O-Mn Bond Environment

$La_{0.6}Y_{0.1}Ca_{0.3}MnO_{3}$, an $ABO_{3}$ perovskite manganite oxide, exhibits a non trivial behavior in the vicinity of the sharp peak found in the resistivity $\rho$ as a function of temperature $T$ in zero magnetic field. The various features seen on $d\rho/dT$ are discussed in terms of competing phase transitions. They are related to the $Mn-O-Mn$ bond environment depending on the content of the $A$ crystallographic site. A Ginzburg-Landau type theory is presented for incorporating concurrent phase transitions. The specific heat $C$ of such a compound is also examined from 50 till 200 K. A log-log analysis indicates different regimes. In the low temperature conducting ferromagnetic phase, a collective magnon signature ($C \simeq T^{3/2}$) is found as for what are called magnon-polaron excitations. A $C \simeq T^{2/3}$ law is found at high temperature and discussed in terms of the fractal dimension of the conducting network of the weakly conducting (so-called insulating) phase and Orbach estimate of the excitation spectral behaviors. The need of considering both independent spin scattering and collective spin scattering is thus emphasized. The report indicates a remarkable agreement for the Fisher-Langer formula, i.e. $C$ $\sim$ $d\rho/dT$ at second order phase transitions. Within the Attfield model, we find an inverse square root relationship between the critical temperature(s) and the total local $Mn-O-Mn$ strain.Comment: 19 pages, 5 figures; to be published in Phys Rev

Giant Magnetoresistive Biosensors for Time-Domain Magnetorelaxometry: A Theoretical Investigation and Progress Toward an Immunoassay.

Magnetorelaxometry (MRX) is a promising new biosensing technique for point-of-care diagnostics. Historically, magnetic sensors have been primarily used to monitor the stray field of magnetic nanoparticles bound to analytes of interest for immunoassays and flow cytometers. In MRX, the magnetic nanoparticles (MNPs) are first magnetized and then the temporal response is monitored after removing the magnetic field. This new sensing modality is insensitive to the magnetic field homogeneity making it more amenable to low-power portable applications. In this work, we systematically investigated time-domain MRX by measuring the signal dependence on the applied field, magnetization time, and magnetic core size. The extracted characteristic times varied for different magnetic MNPs, exhibiting unique magnetic signatures. We also measured the signal contribution based on the MNP location and correlated the coverage with measured signal amplitude. Lastly, we demonstrated, for the first time, a GMR-based time-domain MRX bioassay. This approach validates the feasibility of immunoassays using GMR-based MRX and provides an alternative platform for point-of-care diagnostics

Coexistence of glassy antiferromagnetism and giant magnetoresistance (GMR) in Fe/Cr multilayer structures

Using temperature-dependent magnetoresistance and magnetization measurements on Fe/Cr multilayers that exhibit pronounced giant magnetoresistance (GMR), we have found evidence for the presence of a glassy antiferromagnetic (GAF) phase. This phase reflects the influence of interlayer exchange coupling (IEC) at low temperature (T < 140K) and is characterized by a field-independent glassy transition temperature, Tg, together with irreversible behavior having logarithmic time dependence below a "de Almeida and Thouless" (AT) critical field line. At room temperature, where the GMR effect is still robust, IEC plays only a minor role, and it is the random potential variations acting on the magnetic domains that are responsible for the antiparallel interlayer domain alignment.Comment: 5 pages, 4 figure

Tidal Tails Test the Equivalence Principle in the Dark Sector

Satellite galaxies currently undergoing tidal disruption offer a unique opportunity to constrain an effective violation of the equivalence principle in the dark sector. Theories in which cold dark matter (CDM) couples to a light scalar field naturally lead to a long-range force between dark matter particles. An inverse-square-law force of this kind would manifest itself as a violation of the equivalence principle in the dynamics of CDM compared to baryons in the form of gas or stars. In a previous paper, we showed that an attractive force would displace stars outwards from the bottom of the satellite's gravitational potential well, leading to a higher fraction of stars being disrupted from the tidal bulge further from the Galactic center. Since stars disrupted from the far (near) side of the satellite go on to form the trailing (leading) tidal stream, an attractive dark-matter force will produce a relative enhancement of the trailing stream compared to the leading stream. This distinctive signature of a dark-matter force might be detected through detailed observations of the tidal tails of a disrupting satellite, such as those recently performed by the Two-Micron All-Sky Survey (2MASS) and Sloan Digital Sky Survey (SDSS) on the Sagittarius (Sgr) dwarf galaxy. Here we show that this signature is robust to changes in our models for both the satellite and Milky Way, suggesting that we might hope to search for a dark-matter force in the tidal features of other recently discovered satellite galaxies in addition to the Sgr dwarf.Comment: 29 pages, 13 figures, final version published in PR

The distance to the Orion Nebula

We have used the Very Long Baseline Array to measure the trigonometric parallax of several member stars of the Orion Nebula Cluster showing non-thermal radio emission. We have determined the distance to the cluster to be 414 +/- 7 pc. Our distance determination allows for an improved calibration of luminosities and ages of young stars. We have also measured the proper motions of four cluster stars which, when accurate radial velocities are measured, will put strong constraints on the origin of the cluster.Comment: 13 pages, 3 figures, to appear in Astronomy & Astrophyisc