1,912 research outputs found
An Intelligent Decision Support System for Leukaemia Diagnosis using Microscopic Blood Images
This research proposes an intelligent decision support system for acute lymphoblastic leukaemia
diagnosis from microscopic blood images. A novel clustering algorithm with stimulating discriminant
measures (SDM) of both within- and between-cluster scatter variances is proposed to produce robust
segmentation of nucleus and cytoplasm of lymphocytes/lymphoblasts. Specifically, the proposed
between-cluster evaluation is formulated based on the trade-off of several between-cluster measures
of well-known feature extraction methods. The SDM measures are used in conjuction with Genetic
Algorithm for clustering nucleus, cytoplasm, and background regions. Subsequently, a total of eighty
features consisting of shape, texture, and colour information of the nucleus and cytoplasm subimages
are extracted. A number of classifiers (multi-layer perceptron, Support Vector Machine (SVM)
and Dempster-Shafer ensemble) are employed for lymphocyte/lymphoblast classification. Evaluated
with the ALL-IDB2 database, the proposed SDM-based clustering overcomes the shortcomings of
Fuzzy C-means which focuses purely on within-cluster scatter variance. It also outperforms Linear
Discriminant Analysis and Fuzzy Compactness and Separation for nucleus-cytoplasm separation.
The overall system achieves superior recognition rates of 96.72% and 96.67% accuracies using
bootstrapping and 10-fold cross validation with Dempster-Shafer and SVM, respectively. The results
also compare favourably with those reported in the literature, indicating the usefulness of the
proposed SDM-based clustering method
Application of Linear Discriminant Analysis in Dimensionality Reduction for Hand Motion Classification
The classification of upper-limb movements based on surface electromyography (EMG) signals is an important issue in the control of assistive devices and rehabilitation systems. Increasing the number of EMG channels and features in order to increase the number of control commands can yield a high dimensional feature vector. To cope with the accuracy and computation problems associated with high dimensionality, it is commonplace to apply a processing step that transforms the data to a space of significantly lower dimensions with only a limited loss of useful information. Linear discriminant analysis (LDA) has been successfully applied as an EMG feature projection method. Recently, a number of extended LDA-based algorithms have been proposed, which are more competitive in terms of both classification accuracy and computational costs/times with classical LDA. This paper presents the findings of a comparative study of classical LDA and five extended LDA methods. From a quantitative comparison based on seven multi-feature sets, three extended LDA-based algorithms, consisting of uncorrelated LDA, orthogonal LDA and orthogonal fuzzy neighborhood discriminant analysis, produce better class separability when compared with a baseline system (without feature projection), principle component analysis (PCA), and classical LDA. Based on a 7-dimension time domain and time-scale feature vectors, these methods achieved respectively 95.2% and 93.2% classification accuracy by using a linear discriminant classifier
Early hospital mortality prediction using vital signals
Early hospital mortality prediction is critical as intensivists strive to
make efficient medical decisions about the severely ill patients staying in
intensive care units. As a result, various methods have been developed to
address this problem based on clinical records. However, some of the laboratory
test results are time-consuming and need to be processed. In this paper, we
propose a novel method to predict mortality using features extracted from the
heart signals of patients within the first hour of ICU admission. In order to
predict the risk, quantitative features have been computed based on the heart
rate signals of ICU patients. Each signal is described in terms of 12
statistical and signal-based features. The extracted features are fed into
eight classifiers: decision tree, linear discriminant, logistic regression,
support vector machine (SVM), random forest, boosted trees, Gaussian SVM, and
K-nearest neighborhood (K-NN). To derive insight into the performance of the
proposed method, several experiments have been conducted using the well-known
clinical dataset named Medical Information Mart for Intensive Care III
(MIMIC-III). The experimental results demonstrate the capability of the
proposed method in terms of precision, recall, F1-score, and area under the
receiver operating characteristic curve (AUC). The decision tree classifier
satisfies both accuracy and interpretability better than the other classifiers,
producing an F1-score and AUC equal to 0.91 and 0.93, respectively. It
indicates that heart rate signals can be used for predicting mortality in
patients in the ICU, achieving a comparable performance with existing
predictions that rely on high dimensional features from clinical records which
need to be processed and may contain missing information.Comment: 11 pages, 5 figures, preprint of accepted paper in IEEE&ACM CHASE
2018 and published in Smart Health journa
Automated design of robust discriminant analysis classifier for foot pressure lesions using kinematic data
In the recent years, the use of motion tracking systems for acquisition of functional biomechanical gait data, has received increasing interest due to the richness and accuracy of the measured kinematic information. However, costs frequently restrict the number of subjects employed, and this makes the dimensionality of the collected data far higher than the available samples. This paper applies discriminant analysis algorithms to the classification of patients with different types of foot lesions, in order to establish an association between foot motion and lesion formation. With primary attention to small sample size situations, we compare different types of Bayesian classifiers and evaluate their performance with various dimensionality reduction techniques for feature extraction, as well as search methods for selection of raw kinematic variables. Finally, we propose a novel integrated method which fine-tunes the classifier parameters and selects the most relevant kinematic variables simultaneously. Performance comparisons are using robust resampling techniques such as Bootstrapand k-fold cross-validation. Results from experimentations with lesion subjects suffering from pathological plantar hyperkeratosis, show that the proposed method can lead tocorrect classification rates with less than 10% of the original features
Multiple Data-Dependent Kernel Fisher Discriminant Analysis for Face Recognition
Kernel Fisher discriminant analysis (KFDA) method has demonstrated its success in extracting facial features for face recognition. Compared to linear techniques, it can better describe the complex and nonlinear variations of face images. However, a single kernel is not always suitable for the applications of face recognition which contain data from multiple, heterogeneous sources, such as face images under huge variations of pose, illumination, and facial expression. To improve the performance of KFDA in face recognition, a novel algorithm named multiple data-dependent kernel Fisher discriminant analysis (MDKFDA) is proposed in this paper. The constructed multiple data-dependent kernel (MDK) is a combination of several base kernels with a data-dependent kernel constraint on their weights. By solving the optimization equation based on Fisher criterion and maximizing the margin criterion, the parameter optimization of data-dependent kernel and multiple base kernels is achieved. Experimental results on the three face databases validate the effectiveness of the proposed algorithm
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