Functional and structural brain differences associated with mirror-touch synaesthesia

Observing touch is known to activate regions of the somatosensory cortex but the interpretation of this finding is controversial (e.g. does it reflect the simulated action of touching or the simulated reception of touch?). For most people, observing touch is not linked to reported experiences of feeling touch but in some people it is (mirror-touch synaesthetes). We conducted an fMRI study in which participants (mirror-touch synaesthetes, controls) watched movies of stimuli (face, dummy, object) being touched or approached. In addition we examined whether mirror touch synaesthesia is associated with local changes of grey and white matter volume in the brain using VBM (voxel-based morphometry). Both synaesthetes and controls activated the somatosensory system (primary and secondary somatosensory cortices, SI and SII) when viewing touch, and the same regions were activated (by a separate localiser) when feeling touch — i.e. there is a mirror system for touch. However, when comparing the two groups, we found evidence that SII seems to play a particular important role in mirror-touch synaesthesia: in synaesthetes, but not in controls, posterior SII was active for watching touch to a face (in addition to SI and posterior temporal lobe); activity in SII correlated with subjective intensity measures of mirror-touch synaesthesia (taken outside the scanner), and we observed an increase in grey matter volume within the SII of the synaesthetes' brains. In addition, the synaesthetes showed hypo-activity when watching touch to a dummy in posterior SII. We conclude that the secondary somatosensory cortex has a key role in this form of synaesthesia

Do synaesthesia and mental imagery tap into similar cross-modal processes?

Synaesthesia has previously been linked with imagery abilities, although an understanding of a causal role for mental imagery in broader synaesthetic experiences remains elusive. This can be partly attributed to our relatively poor understanding of imagery in sensory domains beyond vision. Investigations into the neural and behavioural underpinnings of mental imagery have nevertheless identified an important role for imagery in perception, particularly in mediating cross-modal interactions. However, the phenomenology of synaesthesia gives rise to the assumption that associated cross-modal interactions may be encapsulated and specific to synaesthesia. As such, evidence for a link between imagery and perception may not generalize to synaesthesia. Here, we present results that challenge this idea: first, we found enhanced somatosensory imagery evoked by visual stimuli of body parts in mirror-touch synaesthetes, relative to other synaesthetes or controls. Moreover, this enhanced imagery generalized to tactile object properties not directly linked to their synaesthetic associations. Second, we report evidence that concurrent experience evoked in grapheme-colour synaesthesia was sufficient to trigger visual-to-tactile correspondences that are common to all. Together, these findings show that enhanced mental imagery is a consistent hallmark of synaesthesia, and suggest the intriguing possibility that imagery may facilitate the cross-modal interactions that underpin synaesthesic experiences. This article is part of a discussion meeting issue 'Bridging senses: novel insights from synaesthesia'

Mirror-touch synaesthesia: the role of shared representations in social cognition

Synaesthesia is a condition in which one property of a stimulus results in conscious experiences of an additional attribute. In mirror-touch synaesthesia, the synaesthete experiences a tactile sensation on their own body simply when observing touch to another person. This thesis investigates the prevalence, neurocognitive mechanisms, and consequences of mirror-touch synaesthesia. Firstly, the prevalence and neurocognitive mechanisms of synaesthesia were assessed. This revealed that mirrortouch synaesthesia has a prevalence rate of 1.6%, a finding which places mirror-touch synaesthesia as one of the most common variants of synaesthesia. It also indicated a number of characteristics of the condition, which led to the generation of a neurocognitive model of mirror-touch synaesthesia. An investigation into the perceptual consequences of synaesthesia revealed that the presence of synaesthesia is linked with heightened sensory perception - mirror-touch synaesthetes showed heightened tactile perception and grapheme-colour synaesthetes showed heightened colour perception. Given that mirror-touch synaesthesia has been shown to be linked to heightened sensorimotor simulation mechanisms, the impact of facilitated sensorimotor activity on social cognition was then examined. This revealed that mirror-touch synaesthetes show heightened emotional sensitivity compared with control participants. To compliment this, two transcranial magnetic stimulation (TMS) studies were then conducted to assess the impact of suppressing sensorimotor activity on the expression recognition abilities of healthy adults. Consistent with the findings of superior emotion sensitivity in mirror-touch synaesthesia (where there is facilitated sensorimotor activity), suppressing sensorimotor resources resulted in impaired expression recognition across modalities. The findings of the thesis are discussed in relation to neurocognitive models of synaesthesia and of social cognition

The role of the right tempoparietal junction in the elicitation of vicarious experiences and detection accuracy while observing pain and touch

This study investigated the effects of observing pain and touch in others upon vicarious somatosensory experiences and the detection of subtle somatosensory stimuli. Furthermore, transcranial direct current stimulation (tDCS) was used to assess the role of the right temporoparietal junction (rTPJ), as this brain region has been suggested to be involved in perspective taking and self-other distinction. Undergraduates (N = 22) viewed videos depicting hands being touched, hands being pricked, and control scenes (same approaching movement as in the other video categories but without the painful/touching object), while experiencing vibrotactile stimuli themselves on the left, right, or both hands. Participants reported the location at which they felt a somatosensory stimulus. Vibrotactile stimuli and visual scenes were applied in a congruent or incongruent way. During three separate testing sessions, excitability of the rTPJ was modulated with tDCS (cathodal, anodal, or sham). We calculated the proportion of correct responses and false alarms (i.e., number of trials in which a vicarious somatosensory experience was reported congruent to the site of the visual information). Pain-related scenes facilitated the correct detection of tactile stimuli and augmented the number of vicarious somatosensory experiences compared with observing touch or control videos. Stimulation of the rTPJ had no reliable influence upon detection accuracy or the number of vicarious errors. This study indicates that the observation of pain-related scenes compared to the observation of touch or control videos increases the likelihood that a somatosensory stimulus is detected. Contrary to our expectations, the rTPJ did not modulate detection accuracy

Sharing Social Touch in the Primary Somatosensory Cortex

SummaryTouch has an emotional and communicative meaning, and it plays a crucial role in social perception and empathy. The intuitive link between others’ somatosensations and our sense of touch becomes ostensible in mirror-touch synesthesia, a condition in which the view of a touch on another person’s body elicits conscious tactile sensations on the observer’s own body [1]. This peculiar phenomenon may implicate normal social mirror mechanisms [2]. Here, we show that mirror-touch interference effects, synesthesia-like sensations, and even phantom touches can be induced in nonsynesthetes by priming the primary somatosensory cortex (SI) directly or indirectly via the posterior parietal cortex. These results were obtained by means of facilitatory paired-pulse transcranial magnetic stimulation (ppTMS) contingent upon the observation of touch. For these vicarious effects, the SI is engaged at 150 ms from the onset of the visual touch. Intriguingly, individual differences in empathic abilities, assessed with the Interpersonal Reactivity Index [3], drive the activity of the SI when nonsynesthetes witness others’ tactile sensations. This evidence implies that, under normal conditions, touch observation activates the SI below the threshold for perceptual awareness [4]; through the visual-dependent tuning of SI activity by ppTMS, what is seen becomes felt, namely, mirror-touch synesthesia. On a broader perspective, the visual responsivity of the SI may allow an automatic and unconscious transference of the sensation that another person is experiencing onto oneself, and, in turn, the empathic sharing of somatosensations [2]

What can synaesthesia tell us about our minds?

Synaesthesia is considered here as a cognitive phenomenon in the context of developmental, neuropathological and linguistic perspectives. Developmental synaesthesia seems to arise as an effect of interplay between genotype and phenotype, during the implicit learning process in childhood, in those individuals who possess an inborn susceptibility to it. Some connections between synaesthesia and extraordinary experiences, brain restructuration and pain, are examined. Acquired types of synaesthesia may be related to sensory deprivation. The somatosensory cortex may be significant for cognitive synaesthesia, with especial importance placed on a mirror system. It is suggested here that synaesthesia might play a compensatory role during the sensorimotor stage of development. Linguistic-colour synaesthesia seems to be an abstract type of association that may characterize people with a hypersensitive colour perceptual system. In the present view synaesthesia may be seen as an effect of some deficiency that concerns double integrative processes

A systematic study of personification in synaesthesia: Behavioural and neuroimaging studies

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel UniversityIn synaesthetic personification, personality traits and other human characteristics are attributed to linguistic sequences and objects. Such non-perceptual concurrents are different from those found in most frequently studied types of synaesthesia, in which the eliciting stimuli induce sensory experiences. Here, subjective reports from synaesthetes were analysed and the cognitive and neural mechanisms underlying personification were investigated. Specifically, the neural bases of personification were examined using functional MRI in order to establish whether brain regions implicated in social cognition are involved in implementing personification. Additional behavioural tests were used to determine whether personification of inanimate objects is automatic in synaesthesia. Subjective reports describing general characteristics of synaesthetic personification were collected using a semi-structured questionnaire. A Stroop-like paradigm was developed in order to examine the automaticity of object personification, similarly to the previous investigations. Synaesthetes were significantly slower in responding to incongruent than to congruent stimuli. This difference was not found in the control group. The functional neuroimaging investigations demonstrated that brain regions involved in synaesthetic personification of graphemes and objects partially overlap with brain areas activated in normal social cognition, including the temporo-parietal junction, precuneus and posterior cingulate cortex. Activations were observed in areas known to be correlated with mentalising, reflecting the social and affective character of concurrents described in subjective reports. Psychological factors linked with personification in previous studies were also assessed in personifiers, using empathy, mentalising and loneliness scales. Neither heightened empathy nor mentalising were found to be necessary for personification, but personifying synaesthetes in the study felt lonelier than the general population, and this was more pronounced in those who personified more. These results demonstrate that personification shares many defining characteristics with classical forms of synaesthesia. Ascribing humanlike characteristics to graphemes and objects is a spontaneous and automatic process, inducer-concurrent pairings are consistent over time and the phenomenological character of concurrents is reflected in functional neuroanatomy. Furthermore, the neuroimaging findings are consistent with the suggestions that synaesthetes have a lower threshold for activation brain regions implicated in self-projection and mentalising, which may facilitate the personification processes in synaesthesia.Brunel University - Isambard Scholarshi

Atypical bodily self-awareness in vicarious pain responders

Vicarious perception refers to the ability to co-represent the experiences of others. Prior research has shown considerable inter-individual variability in vicarious perception of pain, with some experiencing conscious sensations of pain on their own body when viewing another person in pain (conscious vicarious perception / mirror-pain synaesthesia). Self-Other Theory proposes that this conscious vicarious perception may result from impairments in self-other distinction and maintaining a coherent sense of bodily self. In support of this, individuals who experience conscious vicarious perception are more susceptible to illusions of body ownership and agency. However, little work has assessed whether trait differences in bodily self-awareness are associated with conscious vicarious pain. Here we addressed this gap by examining individual difference factors related to awareness of the body, in conscious vicarious pain responders. Increased self-reported depersonalisation and interoceptive sensibility was found for conscious vicarious pain responders compared with non-responders, in addition to more internally-oriented thinking (associated with lower alexithymia). There were no significant differences in trait anxiety. Results indicate that maintaining a stable sense of the bodily self may be important for vicarious perception of pain, and that vicarious perception might also be enhanced by attention towards internal bodily states

Perceptual abnormalities in amputees: phantom pain, mirror-touch synaesthesia and referred tactile sensations

It is often reported that after amputation people experience "a constant or inconstant... sensory ghost... faintly felt at time, but ready to be called up to [their] perception" (Mitchell, 1866). Perceptual abnormalities have been highlighted in amputees, such as sensations in the phantom when being stroked elsewhere (Ramachandran et al., 1992) or when observing someone in pain (Giummarra and Bradshaw, 2008). This thesis explored the perceptual changes that occur following amputation whist focusing on pain, vision and touch. A sample of over 100 amputees were recruited through the National Health Service. Despite finding no difference in phantom pain based on physical amputation details or nonpainful perceptual phenomena, results from Paper 1 indicated that phantom pain may be more intense, with sensations occurring more frequently, in amputees whose pain was triggerinduced. The survey in Paper 2 identified a group of amputees who in losing a limb acquired mirror-touch synaesthesia. Higher levels of empathy found in mirror-touch amputees might mean that some people are predisposed to develop synaesthesia, but that it takes sensory loss to bring dormant cross-sensory interactions into consciousness. Although the mirror-system may reach supra-threshold levels in some amputees, the experiments in Paper 3 suggested a relatively intact mirror-system in amputees overall. Specifically, in a task of apparent biological motion, amputees showed a similar, although weaker, pattern of results to normalbodied participants. The results of Paper 4 showed that tactile spatial acuity on the face was also largely not affected by amputation, as no difference was found between the sides ipsilateral and contralateral to the stump. In Paper 5 cross-modal cuing was used to investigate whether referred tactile sensations could prime a visually presented target in space occupied by the phantom limb. We conclude that perception is only moderately affected in most amputees, but that in some the sensory loss causes normally sub-threshold processing to enhance into conscious awareness