Factors related to fatigue in systemic lupus erythematosus : a cohort cross-sectional study

Background Fatigue is the most prevalent symptom in Systemic Lupus Erythematosus (SLE) as it is present in up to 90% of patients; it is considered to be the most disabling symptom in around half of the patients [1,2]. Its aetiology is multi-factorial and there is conflicting evidence on the relationship between fatigue and SLE disease activity, and between fatigue and vitamin D deficiency. The Ad Hoc Committee on Systemic Lupus Erythematosus Response Criteria for Fatigue recommended the Fatigue Severity Scale (FSS) for the measurement of fatigue in SLE [2,3].peer-reviewe

High temperature fatigue characteristics of P/M and hot-forged W-Re and TZM for X-ray target of CT scanner

The fatigue strengths at 1000 °C of layered W-Re/TZM, bulk W-Re and bulk TZM for x-ray target materials were successfully evaluated under load-controlled four-point bending by introducing a fatigue failure criterion as twotimes increase of initial compliance. The obtained fatigue strengths at 1000 °C for layered W-Re/TZM and bulk WRe were similar and 280 MPa and 290 MPa at 106 cycles, respectively, while that of bulk TZM was 200 MPa. During fatigue loading at 1000 °C, dominant fatigue damage would be multiple intergranular crack nucleation and propagation, which would induce the increase of compliance. The reasonability of the fatigue failure criterion was confirmed by the fatigue process observations and the results of room temperature fatigue tests of the specimens tested at 1000 °C up to the cycles corresponding to the fatigue failure criterion

Influence of anodizing process on fatigue life of a machined aluminium alloy

In order to investigate the coupled effects of machining and anodizing processes on fatigue life of alloy 7010-T7451, a series of rotating bending fatigue tests were conducted at 60Hz. In the as machined condition, test results showed that fatigue life is surface roughness dependent and that fatigue life decreases with an increase in surface roughness and this effect is found to be more pronounced in high cycle fatigue where major portion of fatigue life is consumed in nucleating the cracks. Effects of pretreatments, like degreasing and pickling employed prior to anodizing, on fatigue life of the given alloy were also studied. Results demonstrated that degreasing showed no change in fatigue life while pickling had negative impact on fatigue life of specimens. The small decrease in fatigue life of anodized specimens as compare to pickled specimens is attributed to brittle and microcracking of the coating. Scanning electron microscopic (SEM) examination revealed multi-site crack initiation for the pickled and anodized specimens. SEM examination showed that pickling solution attacked the grain boundaries and intermetallic inclusions present on the surface resulting in pits formation. These pits are of primary concern with respect to accelerated fatigue crack nucleation and subsequent anodized coating formation

Fatigue performance of thermal spray coatings on carbon steel: a review

This paper contributes to a review of the research of the fatigue behaviour of thermal spray coatings on carbon steel. Previous studies provide the experimental characterization of the fatigue resistance of coated carbon steel. Different coating powders were deposited to a different type of carbon steels. Also, S-N curves were drawn from axial- and rotating bending fatigue test to determine the fatigue strength or fatigue limit of the samples. Thermal spray coatings showed great improvement to the work hardening effect but worsen the fatigue life due to the inclusion of oxide and pores, the presence of stress concentrators, and high microcrack density. Moreover, the effects of the surrounding environment have also resulted in pros and cons towards the fatigue strength. An improvement, however, can be done with the shot peening treatment, which significantly increases the compressive residual stress at interfaces of coating/substrate. The high compressive residual stress could delay the crack nucleation, thus increasing the fatigue life of the coated part

THE RELATIONSHIP BETWEEN MUSCULOSKELETAL STRENGTH, PHYSIOLOGICAL CHARACTERISTICS, AND KNEE KINESTHESIA FOLLOWING FATIGUING EXERCISE

Fatiguing exercise may result in impaired functional joint stability and increased risk of unintentional injury. While there are several musculoskeletal and physiological characteristics related to fatigue onset, their relationship with proprioceptive changes following fatigue has not been examined. The purpose of this study was to establish the relationship between musculoskeletal and physiological characteristics and changes in proprioception, measured by threshold to detect passive motion (TTDPM), following fatiguing exercise. Twenty, physically active females participated (age: 28.65 ± 5.6 years, height: 165.6 ± 4.3 cm, weight: 61.8 ± 8.0 kg, BMI: 22.5± 2.3 kg/m2, BF: 23.3 ± 5.4%). During Visit 1, subjects completed an exercise history and 24-hour dietary questionnaire, and body composition, TTDPM familiarization, isokinetic knee strength, and maximal oxygen uptake/lactate threshold assessments. During Visit 2, subjects completed TTDPM and isometric knee strength testing prior to and following a fatiguing exercise protocol. Wilcoxon signed rank tests determined TTDPM and isometric knee strength changes from pre- to post- fatigue. Spearman’s rho correlation coefficients determined the relationship between strength and physiological variables with pre- to post-fatigue changes in TTDPM and with pre-fatigue and post-fatigue TTDPM in extension and flexion (α=0.05). No significant differences were demonstrated from pre-fatigue to post-fatigue TTDPM despite a significant decrease in isometric knee flexion strength (P<0.01) and flexion/extension ratio (P<0.05) following fatigue. No significant correlations were observed between strength or physiological variables and changes in TTDPM from pre- to post-fatigue in extension or flexion. Flexion/extension ratio was significantly correlated with pre-fatigue TTDPM in extension (r=-0.231, P<0.05). Peak oxygen uptake was significantly correlated with pre-fatigue (r=-0.500, P<0.01) and post-fatigue (r=-0.520, P<0.05) TTDPM in extension. No significant relationships were demonstrated between musculoskeletal and physiological characteristics and changes in TTDPM following fatigue. The results suggest that highly trained individuals may have better proprioception, and that the high fitness level of subjects in this investigation may have contributed to absence of TTDPM deficits following fatigue despite reaching a high level of perceptual and physiological fatigue. Future studies should consider various subject populations, other musculoskeletal strength characteristics, and different modalities of proprioception to determine the most important contributions to proprioceptive changes following fatigue

Postural destabilization induced by trunk extensor muscles fatigue is suppressed by use of a plantar pressure-based electro-tactile biofeedback

Separate studies have reported that postural control during quiet standing could be (1) impaired with muscle fatigue localized at the lower back, and (2) improved through the use of plantar pressure-based electro-tactile biofeedback, under normal neuromuscular state. The aim of this experiment was to investigate whether this biofeedback could reduce postural destabilization induced by trunk extensor muscles. Ten healthy adults were asked to stand as immobile as possible in four experimental conditions: (1) no fatigue/no biofeedback, (2) no fatigue/biofeedback, (3) fatigue/no biofeedback and (4) fatigue/biofeedback. Muscular fatigue was achieved by performing trunk repetitive extensions until maximal exhaustion. The underlying principle of the biofeedback consisted of providing supplementary information related to foot sole pressure distribution through electro-tactile stimulation of the tongue. Centre of foot pressure (CoP) displacements were recorded using a force platform. Results showed (1) increased CoP displacements along the antero-posterior axis in the fatigue than no fatigue condition in the absence of biofeedback and (2) no significant difference between the no fatigue and fatigue conditions in the presence of biofeedback. This suggests that subjects were able to efficiently integrate an artificial plantar pressure information delivered through electro-tactile stimulation of the tongue that allowed them to suppress the destabilizing effect induced by trunk extensor muscles fatigue

Obtaining the fatigue laws of bituminous mixtures from a strain sweep test: effect of temperature and aging

Fatigue is associated with the deterioration caused by applying repeated loads, and is affected by temperature or aging. Generally, time sweep tests are used to simulate fatigue, in order to obtain the fatigue laws. However, this requires too much time, often preventing its use. A method to estimate the fatigue laws from a strain sweep test is presented. The test was performed on a semi-dense mixture with different types of binder (unconditioned or aged) tested at different temperatures. This test is able to estimate fatigue laws more quickly, allowing the effect of different factors on the mixtures' fatigue life to be studied.Peer ReviewedPostprint (author's final draft

A mission synthesis algorithm for editing variable amplitude fatigue signals

This paper presents a wavelet-based fatigue data editing algorithm, known as Wavelet Bump Extraction (WBE), to summarise long record of fatigue loadings. The key point of this algorithm is to produce a shorter time history (mission signal) that retains the majority of the original fatigue damage whilst preserving cycle sequence information. In WBE, features or bumps are identified in characteristic frequency bands using the Daubechies’ wavelet transform. Comparison of the fatigue life between the original and mission signals was performed to validate the algorithm. The fatigue life was predicted using a variable amplitude fatigue damage model and the results showed a good correlation between the damage caused by the original and mission signals. Finally, the findings suggest that WBE is a suitable approach for producing a shortened mission signal for accelerated fatigue testing

Muscle fatigue degrades force sense at the ankle joint

To investigate the effects of muscle fatigue on force sense at the ankle joint, 10 young healthy adults were asked to perform an isometric contra-lateral force ankle-matching task in two experimental conditions of: (1) no-fatigue and (2) fatigue of the plantar-flexor muscles. Measures of the overall accuracy and the variability of the force matching performances were determined using the absolute error and the variable error, respectively. Results showed less accurate and less consistent force matching performances in the fatigue than no fatigue condition, as indicated by decreased absolute and variable errors, respectively. The present findings evidence that muscle fatigue degrades force sense at the ankle joint