Stress and deformation of optimally shaped silicon microneedles for transdermal drug delivery

In this study, we demonstrated the fabrication of the concave conic shape microneedle with the aid of COMSOL Multiphysics simulation. The stress and buckling of the microneedle structure were simulated by applying various loads ranging from 50 to 800 g perpendiculars to the tip in order to predict the occurrence of microneedles structure deformation. The simulation study indicated that the surface buckling deformation does not occur to the microneedle structure with the increment of the load. The microneedles with dimensions of height and diameter tip ranging from 60 to 100 μm and 1 to 4 μm, respectively had been fabricated via an etching process in a mixture of hydrofluoric acid, nitric acid, and acetic acid. Three optimized microneedles but different in the structures were fabricated via the acidic etching process. The reproducibility of three different microneedle structures was 15, 20, and 60%, respectively. Stress and buckling analyses of the fabricated microneedles were further carried out on the rat skin. The obtained experimental results show promising applications for the deep dermis, stratum corneum to epidermis layer penetration

Analysis of Fade Dynamic at Ku-Band in Malaysia

This work investigates fade dynamics of satellite communication systems in equatorial heavy rain region based on a one year of Ku-band propagation measurement campaign carried out in Universiti Teknologi Malaysia (UTM), Johor, Malaysia. First order statistics of rain attenuation are deduced and the results are found to be in good agreement with those obtained from other beacon measurements gathered within the same area (Kuala Lumpur). Moreover, the fade duration and slope statistics of the satellite signal variations are also carefully derived and subsequently compared with the ITU-R recommendation model. Such information is useful for the system operator and radio communication engineer for the design of appropriate fade mitigation techniques as well as the quality of service that could be offered to the user (according to the time interval for a typical day). Further evaluation on the performances of several ITU-R models in the heavy rain region are needed based on the measurement database available of this climatic region

Variance In Fade-time Of A Gamma-gamma Distributed Irradiance Signal

Free-space optical communications are predominantly hindered by optical turbulence, an effect caused by temperature and pressure variations within the atmosphere. The result is an optical wave interfering with itself due to multipath propagation via tiny refractive-index fluctuations across the wave-front. Optical communication systems are affected when the channel conditions induce fading in the irradiance signal that is received at the detector. The nature of optical interference imparted by the atmosphere is a random process and therefore the received irradiance signal is often characterized by an appropriate probability density function (PDF). Data collected during past free-space optical experiments in the atmosphere support the gammagamma distribution as a practical PDF model for received irradiance fluctuations, although the irradiance fluctuations do occasionally tend towards a lognormal distribution. Utilization of the gamma-gamma irradiance PDF allows for calculation of statistical moments of the irradiance threshold level-crossing distribution. Presented analysis focuses on the results of the gamma-gamma irradiance PDF. Previously, expressions were developed for the expected number of gamma-gamma distributed irradiance threshold level-crossings. Expressions for the mean square number of gamma-gamma distributed irradiance threshold level-crossings are derived and presented. The derived expressions lead to the mean and variance of signal fade time. Outcomes of the derived expressions are presented in relation to free-space optical communication system performance. iii Comparisons are made between the theoretical analysis and experimental data taken at the Innovative Science and Technology Facility (ISTEF) located at the Kennedy Space Center in Cape Canaveral, Florida. The strength of the atmospheric turbulence is often characterized by three measurable parameters: the refractive index structure constant �� 2 , the inner scale �0 , and the outer scale �0 . The optical path (�~1��) was instrumented such that direct comparisons could be drawn between the measured atmospheric turbulence parameters and the parameters of the gamma-gamma irradiance model. Variance of fade time data were found to agree well for smaller apertures where effects of aperture averaging are not present and in cases where scintillation is weak to moderate. It is suggested that a more appropriate PDF, with a heavier focus on aperture averaging, may be applied in future studies of these fade statistics

Proceedings of the Seventeenth NASA Propagation Experimenters Meeting (NAPEX 17) and the Advanced Communications Technology Satellite (ACTS) Propagation Studies Miniworkshop

The NASA Propagation Experimenters Meeting (NAPEX) is convened annually to discuss studies made on radio wave propagation by investors from domestic and international organizations. NAPEX 17 was held on 15 June 1993. The meeting was organized into two technical sessions. The first session was dedicated to slant path propagation studies and experiments. The second session focused on propagation studies for mobile and personal communications. Preceding NAPEX 17, the Advanced Communications Technology Satellite (ACTS) Propagation Studies Miniworkshop was held on 14 June 1993 to review ACTS propagation activities with emphasis on ACTS experiments status and data collection, processing, and exchange

Driven Tunneling: Chaos and Decoherence

Chaotic tunneling in a driven double-well system is investigated in absence as well as in the presence of dissipation. As the constitutive mechanism of chaos-assisted tunneling, we focus on the dynamics in the vicinity of three-level crossings in the quasienergy spectrum. The coherent quantum dynamics near the crossing is described satisfactorily by a three-state model. It fails, however, for the corresponding dissipative dynamics, because incoherent transitions due to the interaction with the environment indirectly couple the three states in the crossing to the remaining quasienergy states. The asymptotic state of the driven dissipative quantum dynamics partially resembles the, possibly strange, attractor of the corresponding damped driven classical dynamics, but also exhibits characteristic quantum effects.Comment: 32 pages, 35 figures, lamuphys.st