RELEAF: An Algorithm for Learning and Exploiting Relevance

Recommender systems, medical diagnosis, network security, etc., require on-going learning and decision-making in real time. These -- and many others -- represent perfect examples of the opportunities and difficulties presented by Big Data: the available information often arrives from a variety of sources and has diverse features so that learning from all the sources may be valuable but integrating what is learned is subject to the curse of dimensionality. This paper develops and analyzes algorithms that allow efficient learning and decision-making while avoiding the curse of dimensionality. We formalize the information available to the learner/decision-maker at a particular time as a context vector which the learner should consider when taking actions. In general the context vector is very high dimensional, but in many settings, the most relevant information is embedded into only a few relevant dimensions. If these relevant dimensions were known in advance, the problem would be simple -- but they are not. Moreover, the relevant dimensions may be different for different actions. Our algorithm learns the relevant dimensions for each action, and makes decisions based in what it has learned. Formally, we build on the structure of a contextual multi-armed bandit by adding and exploiting a relevance relation. We prove a general regret bound for our algorithm whose time order depends only on the maximum number of relevant dimensions among all the actions, which in the special case where the relevance relation is single-valued (a function), reduces to $\tilde{O}(T^{2(\sqrt{2}-1)})$; in the absence of a relevance relation, the best known contextual bandit algorithms achieve regret $\tilde{O}(T^{(D+1)/(D+2)})$, where $D$ is the full dimension of the context vector.Comment: to appear in IEEE Journal of Selected Topics in Signal Processing, 201

Machine Learning and Integrative Analysis of Biomedical Big Data.

Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues

Fast Robust PCA on Graphs

Mining useful clusters from high dimensional data has received significant attention of the computer vision and pattern recognition community in the recent years. Linear and non-linear dimensionality reduction has played an important role to overcome the curse of dimensionality. However, often such methods are accompanied with three different problems: high computational complexity (usually associated with the nuclear norm minimization), non-convexity (for matrix factorization methods) and susceptibility to gross corruptions in the data. In this paper we propose a principal component analysis (PCA) based solution that overcomes these three issues and approximates a low-rank recovery method for high dimensional datasets. We target the low-rank recovery by enforcing two types of graph smoothness assumptions, one on the data samples and the other on the features by designing a convex optimization problem. The resulting algorithm is fast, efficient and scalable for huge datasets with O(nlog(n)) computational complexity in the number of data samples. It is also robust to gross corruptions in the dataset as well as to the model parameters. Clustering experiments on 7 benchmark datasets with different types of corruptions and background separation experiments on 3 video datasets show that our proposed model outperforms 10 state-of-the-art dimensionality reduction models. Our theoretical analysis proves that the proposed model is able to recover approximate low-rank representations with a bounded error for clusterable data

Statistics in the Big Data era

It is estimated that about 90% of the currently available data have been produced over the last two years. Of these, only 0.5% is effectively analysed and used. However, this data can be a great wealth, the oil of 21st century, when analysed with the right approach. In this article, we illustrate some specificities of these data and the great interest that they can represent in many fields. Then we consider some challenges to statistical analysis that emerge from their analysis, suggesting some strategies