Scalable and Declarative Information Extraction in a Parallel Data Analytics System

Informationsextraktions (IE) auf sehr großen Datenmengen erfordert hochkomplexe, skalierbare und anpassungsfähige Systeme. Obwohl zahlreiche IE-Algorithmen existieren, ist die nahtlose und erweiterbare Kombination dieser Werkzeuge in einem skalierbaren System immer noch eine große Herausforderung. In dieser Arbeit wird ein anfragebasiertes IE-System für eine parallelen Datenanalyseplattform vorgestellt, das für konkrete Anwendungsdomänen konfigurierbar ist und für Textsammlungen im Terabyte-Bereich skaliert. Zunächst werden konfigurierbare Operatoren für grundlegende IE- und Web-Analytics-Aufgaben definiert, mit denen komplexe IE-Aufgaben in Form von deklarativen Anfragen ausgedrückt werden können. Alle Operatoren werden hinsichtlich ihrer Eigenschaften charakterisiert um das Potenzial und die Bedeutung der Optimierung nicht-relationaler, benutzerdefinierter Operatoren (UDFs) für Data Flows hervorzuheben. Anschließend wird der Stand der Technik in der Optimierung nicht-relationaler Data Flows untersucht und herausgearbeitet, dass eine umfassende Optimierung von UDFs immer noch eine Herausforderung ist. Darauf aufbauend wird ein erweiterbarer, logischer Optimierer (SOFA) vorgestellt, der die Semantik von UDFs mit in die Optimierung mit einbezieht. SOFA analysiert eine kompakte Menge von Operator-Eigenschaften und kombiniert eine automatisierte Analyse mit manuellen UDF-Annotationen, um die umfassende Optimierung von Data Flows zu ermöglichen. SOFA ist in der Lage, beliebige Data Flows aus unterschiedlichen Anwendungsbereichen logisch zu optimieren, was zu erheblichen Laufzeitverbesserungen im Vergleich mit anderen Techniken führt. Als Viertes wird die Anwendbarkeit des vorgestellten Systems auf Korpora im Terabyte-Bereich untersucht und systematisch die Skalierbarkeit und Robustheit der eingesetzten Methoden und Werkzeuge beurteilt um schließlich die kritischsten Herausforderungen beim Aufbau eines IE-Systems für sehr große Datenmenge zu charakterisieren.Information extraction (IE) on very large data sets requires highly complex, scalable, and adaptive systems. Although numerous IE algorithms exist, their seamless and extensible combination in a scalable system still is a major challenge. This work presents a query-based IE system for a parallel data analysis platform, which is configurable for specific application domains and scales for terabyte-sized text collections. First, configurable operators are defined for basic IE and Web Analytics tasks, which can be used to express complex IE tasks in the form of declarative queries. All operators are characterized in terms of their properties to highlight the potential and importance of optimizing non-relational, user-defined operators (UDFs) for dataflows. Subsequently, we survey the state of the art in optimizing non-relational dataflows and highlight that a comprehensive optimization of UDFs is still a challenge. Based on this observation, an extensible, logical optimizer (SOFA) is introduced, which incorporates the semantics of UDFs into the optimization process. SOFA analyzes a compact set of operator properties and combines automated analysis with manual UDF annotations to enable a comprehensive optimization of data flows. SOFA is able to logically optimize arbitrary data flows from different application areas, resulting in significant runtime improvements compared to other techniques. Finally, the applicability of the presented system to terabyte-sized corpora is investigated. Hereby, we systematically evaluate scalability and robustness of the employed methods and tools in order to pinpoint the most critical challenges in building an IE system for very large data sets

User-centered semantic dataset retrieval

Finding relevant research data is an increasingly important but time-consuming task in daily research practice. Several studies report on difficulties in dataset search, e.g., scholars retrieve only partial pertinent data, and important information can not be displayed in the user interface. Overcoming these problems has motivated a number of research efforts in computer science, such as text mining and semantic search. In particular, the emergence of the Semantic Web opens a variety of novel research perspectives. Motivated by these challenges, the overall aim of this work is to analyze the current obstacles in dataset search and to propose and develop a novel semantic dataset search. The studied domain is biodiversity research, a domain that explores the diversity of life, habitats and ecosystems. This thesis has three main contributions: (1) We evaluate the current situation in dataset search in a user study, and we compare a semantic search with a classical keyword search to explore the suitability of semantic web technologies for dataset search. (2) We generate a question corpus and develop an information model to figure out on what scientific topics scholars in biodiversity research are interested in. Moreover, we also analyze the gap between current metadata and scholarly search interests, and we explore whether metadata and user interests match. (3) We propose and develop an improved dataset search based on three components: (A) a text mining pipeline, enriching metadata and queries with semantic categories and URIs, (B) a retrieval component with a semantic index over categories and URIs and (C) a user interface that enables a search within categories and a search including further hierarchical relations. Following user centered design principles, we ensure user involvement in various user studies during the development process

A Knowledge-based Integrative Modeling Approach for <em>In-Silico</em> Identification of Mechanistic Targets in Neurodegeneration with Focus on Alzheimer’s Disease

Dementia is the progressive decline in cognitive function due to damage or disease in the body beyond what might be expected from normal aging. Based on neuropathological and clinical criteria, dementia includes a spectrum of diseases, namely Alzheimer's dementia, Parkinson's dementia, Lewy Body disease, Alzheimer's dementia with Parkinson's, Pick's disease, Semantic dementia, and large and small vessel disease. It is thought that these disorders result from a combination of genetic and environmental risk factors. Despite accumulating knowledge that has been gained about pathophysiological and clinical characteristics of the disease, no coherent and integrative picture of molecular mechanisms underlying neurodegeneration in Alzheimer’s disease is available. Existing drugs only offer symptomatic relief to the patients and lack any efficient disease-modifying effects. The present research proposes a knowledge-based rationale towards integrative modeling of disease mechanism for identifying potential candidate targets and biomarkers in Alzheimer’s disease. Integrative disease modeling is an emerging knowledge-based paradigm in translational research that exploits the power of computational methods to collect, store, integrate, model and interpret accumulated disease information across different biological scales from molecules to phenotypes. It prepares the ground for transitioning from ‘descriptive’ to “mechanistic” representation of disease processes. The proposed approach was used to introduce an integrative framework, which integrates, on one hand, extracted knowledge from the literature using semantically supported text-mining technologies and, on the other hand, primary experimental data such as gene/protein expression or imaging readouts. The aim of such a hybrid integrative modeling approach was not only to provide a consolidated systems view on the disease mechanism as a whole but also to increase specificity and sensitivity of the mechanistic model by providing disease-specific context. This approach was successfully used for correlating clinical manifestations of the disease to their corresponding molecular events and led to the identification and modeling of three important mechanistic components underlying Alzheimer’s dementia, namely the CNS, the immune system and the endocrine components. These models were validated using a novel in-silico validation method, namely biomarker-guided pathway analysis and a pathway-based target identification approach was introduced, which resulted in the identification of the MAPK signaling pathway as a potential candidate target at the crossroad of the triad components underlying disease mechanism in Alzheimer’s dementia

Experiences from Developing the Domain-Specific Entity Search Engine GeneView

Abstract:.GeneView is a semantic search engine for the Life Sciences. Unlike traditional search engines, GeneView searches indexed documents not only at the textual (syntactic) level, but analyzes texts upon import to recognize and properly handle biomedical entities, relationships between those entities, and the structure of documents. This allows for a number of advanced features required to work effectively with scientific texts, such as precise search despite large numbers of synonyms and homonyms, entity disambiguation, ranking of documents by entity content, linking to structured knowledge about entities, user-friendly highlighting of recognized entities etc. As of now, GeneView indexes approximately ~21,4 million abstracts and ~358.000 full texts with more than 200 Million entities of 11 different types and more than 100,000 relationships of three different types. In this paper, we describe the architecture underlying the system with a focus on the complex pipeline of advanced NLP and information extraction tools necessary for achieving the above functionality. We also discuss open challenges in developing and maintaining a semantic search engine over a large (though not web-scale) corpus. 1