The cultural epigenetics of psychopathology: The missing heritability of complex diseases found?

We extend a cognitive paradigm for gene expression based on the asymptotic limit theorems of information theory to the epigenetic epidemiology of mental disorders. In particular, we recognize the fundamental role culture plays in human biology, another heritage mechanism parallel to, and interacting with, the more familiar genetic and epigenetic systems. We do this via a model through which culture acts as another tunable epigenetic catalyst that both directs developmental trajectories, and becomes convoluted with individual ontology, via a mutually-interacting crosstalk mediated by a social interaction that is itself culturally driven. We call for the incorporation of embedding culture as an essential component of the epigenetic regulation of human mental development and its dysfunctions, bringing what is perhaps the central reality of human biology into the center of biological psychiatry. Current US work on gene-environment interactions in psychiatry must be extended to a model of gene-environment-culture interaction to avoid becoming victim of an extreme American individualism that threatens to create paradigms particular to that culture and that are, indeed, peculiar in the context of the world's cultures. The cultural and epigenetic systems of heritage may well provide the 'missing' heritability of complex diseases now under so much intense discussion

Introduction to Microservice API Patterns (MAP)

The Microservice API Patterns (MAP) language and supporting website premiered under this name at Microservices 2019. MAP distills proven, platform- and technology-independent solutions to recurring (micro-)service design and interface specification problems such as finding well-fitting service granularities, rightsizing message representations, and managing the evolution of APIs and their implementations. In this paper, we motivate the need for such a pattern language, outline the language organization and present two exemplary patterns describing alternative options for representing nested data. We also identify future research and development directions

Political Text Scaling Meets Computational Semantics

During the last fifteen years, automatic text scaling has become one of the key tools of the Text as Data community in political science. Prominent text scaling algorithms, however, rely on the assumption that latent positions can be captured just by leveraging the information about word frequencies in documents under study. We challenge this traditional view and present a new, semantically aware text scaling algorithm, SemScale, which combines recent developments in the area of computational linguistics with unsupervised graph-based clustering. We conduct an extensive quantitative analysis over a collection of speeches from the European Parliament in five different languages and from two different legislative terms, and show that a scaling approach relying on semantic document representations is often better at capturing known underlying political dimensions than the established frequency-based (i.e., symbolic) scaling method. We further validate our findings through a series of experiments focused on text preprocessing and feature selection, document representation, scaling of party manifestos, and a supervised extension of our algorithm. To catalyze further research on this new branch of text scaling methods, we release a Python implementation of SemScale with all included data sets and evaluation procedures.Comment: Updated version - accepted for Transactions on Data Science (TDS

Biologically inspired distributed machine cognition: a new formal approach to hyperparallel computation

The irresistable march toward multiple-core chip technology presents currently intractable pdrogramming challenges. High level mental processes in many animals, and their analogs for social structures, appear similarly massively parallel, and recent mathematical models addressing them may be adaptable to the multi-core programming problem

Dysfunctions of highly parallel real-time machines as 'developmental disorders': Security concerns and a Caveat Emptor

A cognitive paradigm for gene expression in developmental biology that is based on rigorous application of the asymptotic limit theorems of information theory can be adapted to highly parallel real-time computing. The coming Brave New World of massively parallel 'autonomic' and 'Self-X' machines driven by the explosion of multiple core and molecular computing technologies will not be spared patterns of canonical and idiosyncratic failure analogous to the developmental disorders affecting organisms that have had the relentless benefit of a billion years of evolutionary pruning. This paper provides a warning both to potential users of these machines and, given that many such disorders can be induced by external agents, to those concerned with larger scale matters of homeland security

Institutional Cognition

We generalize a recent mathematical analysis of Bernard Baars' model of human consciousness to explore analogous, but far more complicated, phenomena of institutional cognition. Individual consciousness is limited to a single, tunable, giant component of interacting cogntivie modules, instantiating a Global Workspace. Human institutions, by contrast, seem able to multitask, supporting several such giant components simultaneously, although their behavior remains constrained to a topology generated by cultural context and by the path-dependence inherent to organizational history. Surprisingly, such multitasking, while clearly limiting the phenomenon of inattentional blindness, does not eliminate it. This suggests that organizations (or machines) explicitly designed along these principles, while highly efficient at certain sets of tasks, would still be subject to analogs of the subtle failure patterns explored in Wallace (2005b, 2006). We compare and contrast our results with recent work on collective efficacy and collective consciousness

Culture and generalized inattentional blindness

A recent mathematical treatment of Baars' Global Workspace consciousness model, much in the spirit of Dretske's communication theory analysis of high level mental function, is used to study the effects of embedding cultural heritage on a generalized form of inattentional blindness. Culture should express itself quite distinctly in this basic psychophysical phenomenon, acting across a variety of sensory and other modalities, because the limited syntactic and grammatical 'bandpass' of the topological rate distortion manifold characterizing conscious attention is itself strongly sculpted by the constraints of cultural context

Topic Identification for Speech without ASR

Modern topic identification (topic ID) systems for speech use automatic speech recognition (ASR) to produce speech transcripts, and perform supervised classification on such ASR outputs. However, under resource-limited conditions, the manually transcribed speech required to develop standard ASR systems can be severely limited or unavailable. In this paper, we investigate alternative unsupervised solutions to obtaining tokenizations of speech in terms of a vocabulary of automatically discovered word-like or phoneme-like units, without depending on the supervised training of ASR systems. Moreover, using automatic phoneme-like tokenizations, we demonstrate that a convolutional neural network based framework for learning spoken document representations provides competitive performance compared to a standard bag-of-words representation, as evidenced by comprehensive topic ID evaluations on both single-label and multi-label classification tasks.Comment: 5 pages, 2 figures; accepted for publication at Interspeech 201

Hunter-gatherers in a howling wilderness: Neoliberal capitalism as a language that speaks itself

The 'self-referential' character of evolutionary process noted by Goldenfeld and Woese (2010) can be restated in the context of a generalized Darwinian theory applied to economic process through a 'language' model: The underlying inherited and learned culture of the firm, the short-time cognitive response of the firm to patterns of threat and opportunity that is sculpted by that culture, and the embedding socioeconomic environment, are represented as interacting information sources constrained by the asymptotic limit theorems of information theory. If unregulated, the larger, compound, source that characterizes high probability evolutionary paths of this composite then becomes, literally, a self-dynamic language that speaks itself. Such a structure is, for those enmeshed in it, more akin to a primitive hunter-gatherer society at the mercy of internal ecological dynamics than to, say, a neolithic agricultural community in which a highly ordered, deliberately adapted, ecosystem is consciously farmed so as to match its productivity to human needs