Eight-Channel Head Array and Control System for Parallel Transmit/Receive Magnetic Resonance Imaging

Interest in magnetic resonance imaging (MRI) at high fields strengths (3 Tesla and above) is driven by the associated improvements in signal-to-noise ratio and spectral resolution. In practice, however, technical challenges prevent these benefits from being straightforwardly realized. High fields are associated with an increase in frequency and a decrease in the radiofrequency (RF) wavelength. The shortened wavelength causes potential inhomogeneity in the transmit field of the RF coil, resulting in non-uniform excitations. Susceptibility effects are also more pronounced at high field strengths, and can cause local distortions in the field and create areas of signal dropout. Parallel transmit is one method in development to address these challenges at high fields. Parallel transmit involves using multiple independently driven channels with RF pulses varying in amplitude, phase, and pulse envelope to create desired transmit excitations. Parallel transmit has been implemented to create homogenous transmit patterns and compensate for magnetic susceptibility effects, but despite its proven usefulness, the technology has yet to receive widespread adoption. Few parallel transmit systems exist and little work has been done in the pre-clinical realm. Studies demonstrating the clinical benefits of parallel transmit constitute a gap in the current body of work. This works presents an approach to a parallel transmit array and control system that can be easily and safely integrated on a clinical whole-body scanner. The transmit array was designed for use with ultra-low output impedance amplifiers and demonstrates an array design with a simplified decoupling network augmented by amplifier decoupling in both transmit and receive. The control system was programmed in LabVIEW using off-the-shelf hardware to manage pulse playback, correct transmit chain non-linearities, monitor on-coil waveforms, and drive the transmit hardware. The transmit array was shown with well-isolated patterns, and parallel transmit capability was demonstrated. This work progressed the translation of experimental parallel transmit technology to pre-clinical use

Design of Radio-Frequency Arrays for Ultra-High Field MRI

Magnetic Resonance Imaging (MRI) is an indispensable, non-invasive diagnostic tool for the assessment of disease and function. As an investigational device, MRI has found routine use in both basic science research and medicine for both human and non-human subjects. Due to the potential increase in spatial resolution, signal-to-noise ratio (SNR), and the ability to exploit novel tissue contrasts, the main magnetic field strength of human MRI scanners has steadily increased since inception. Beginning in the early 1980’s, 0.15 T human MRI scanners have steadily risen in main magnetic field strength with ultra-high field (UHF) 8 T MRI systems deemed to be insignificant risk by the FDA (as of 2016). However, at UHF the electromagnetic fields describing the collective behaviour of spin dynamics in human tissue assume ‘wave-like’ behaviour due to an increase in the processional frequency of nuclei at UHF. At these frequencies, the electromagnetic interactions transition from purely near-field interactions to a mixture of near- and far-field mechanisms. Due to this, the transmission field at UHF can produce areas of localized power deposition – leading to tissue heating – as well as tissue-independent contrast in the reconstructed images. Correcting for these difficulties is typically achieved via multi-channel radio-frequency (RF) arrays. This technology allows multiple transmitting elements to synthesize a more uniform field that can selectively minimize areas of local power deposition and remove transmission field weighting from the final reconstructed image. This thesis provides several advancements in the design and construction of these arrays. First, in Chapter 2 a general framework for modeling the electromagnetic interactions occurring inside an RF array is adopted from multiply-coupled waveguide filters and applied to a subset of decoupling problems encountered when constructing RF arrays. It is demonstrated that using classic filter synthesis, RF arrays of arbitrary size and geometry can be decoupled via coupling matrix synthesis. Secondly, in Chapters 3 and 4 this framework is extended for designing distributed filters for simple decoupling of RF arrays and removing the iterative tuning portion of utilizing decoupling circuits when constructing RF arrays. Lastly, in Chapter 5 the coupling matrix synthesis framework is applied to the construction of a conformal transmit/receive RF array that is shape optimized to minimize power deposition in the human head during any routine MRI examination

Forced Current Excitation in Selectable Field of View Coils for 7T MRI and MRS

High field magnetic resonance imaging (MRI) provides improved signal-to-noise ratio (SNR) which can be translated to higher image resolution or reduced scan time. 7 Tesla (T) breast imaging and 7 T spine imaging are of clinical value, but they are challenging for several reasons: A bilateral breast coil requires the use of closely-spaced elements that are subject to severe mutual coupling which leads to uncontrollable current distribution and non-uniform field pattern; A spine coil at 7T requires a large field of view (FOV) in the z direction and good RF penetration into the human body. Additionally, the ability to switch FOV without the use of expensive high power RF amplifiers is desired in both applications. This capability would allow reconfigurable power distribution and avoid unnecessary heat deposition into human body. Forced-Current Excitation (FCE) is a transmission line-based method that maintains equal current distribution across an array, alleviating mutual coupling effects and allowing current/field replication across a large FOV. At the same time, the nature of this method enables selectable FOV with the inclusion of PIN diodes and a controller. In this doctoral work, the theory of FCE is explained in detail, along with its benefits and drawbacks. Electromagnetic simulation considerations of FCE-driven coils are also discussed. Two FCE-driven coils were designed and implemented: a switchable bilateral/unilateral 7T breast coil, and a segmented dipole for spine imaging at 7T with reconfigurable length. For the breast coil, shielded loop elements were used to form a volume coil, whereas for the spine coil, a segmented dipole was chosen as the final design due to improved RF penetration. Electromagnetic simulations were performed to assist the design of the two coils as well as to predict the SAR (specific absorption rate) generated in the phantom. The coils were evaluated on bench and through MRI experiments in different configurations to validate the design. The switchable breast coil provides uniform excitation in both unilateral and bilateral mode. In unilateral mode, the signal in the contralateral breast is successfully suppressed and higher power is concentrated into the breast of interest; The segmented dipole was compared to a regular dipole with the same length used for 7T spine imaging. The segmented dipole shows a large FOV in the long mode. In the short mode, the residual signal from other part of the dipole is successfully suppressed. The ability to switch FOV and reconfigure the power distribution improves the B1 generated with unit specific absorption rate towards the edge of the dipole, compared to the regular dipole

Forced Current Excitation in Selectable Field of View Coils for 7T MRI and MRS

High field magnetic resonance imaging (MRI) provides improved signal-to-noise ratio (SNR) which can be translated to higher image resolution or reduced scan time. 7 Tesla (T) breast imaging and 7 T spine imaging are of clinical value, but they are challenging for several reasons: A bilateral breast coil requires the use of closely-spaced elements that are subject to severe mutual coupling which leads to uncontrollable current distribution and non-uniform field pattern; A spine coil at 7T requires a large field of view (FOV) in the z direction and good RF penetration into the human body. Additionally, the ability to switch FOV without the use of expensive high power RF amplifiers is desired in both applications. This capability would allow reconfigurable power distribution and avoid unnecessary heat deposition into human body. Forced-Current Excitation (FCE) is a transmission line-based method that maintains equal current distribution across an array, alleviating mutual coupling effects and allowing current/field replication across a large FOV. At the same time, the nature of this method enables selectable FOV with the inclusion of PIN diodes and a controller. In this doctoral work, the theory of FCE is explained in detail, along with its benefits and drawbacks. Electromagnetic simulation considerations of FCE-driven coils are also discussed. Two FCE-driven coils were designed and implemented: a switchable bilateral/unilateral 7T breast coil, and a segmented dipole for spine imaging at 7T with reconfigurable length. For the breast coil, shielded loop elements were used to form a volume coil, whereas for the spine coil, a segmented dipole was chosen as the final design due to improved RF penetration. Electromagnetic simulations were performed to assist the design of the two coils as well as to predict the SAR (specific absorption rate) generated in the phantom. The coils were evaluated on bench and through MRI experiments in different configurations to validate the design. The switchable breast coil provides uniform excitation in both unilateral and bilateral mode. In unilateral mode, the signal in the contralateral breast is successfully suppressed and higher power is concentrated into the breast of interest; The segmented dipole was compared to a regular dipole with the same length used for 7T spine imaging. The segmented dipole shows a large FOV in the long mode. In the short mode, the residual signal from other part of the dipole is successfully suppressed. The ability to switch FOV and reconfigure the power distribution improves the B1 generated with unit specific absorption rate towards the edge of the dipole, compared to the regular dipole

Isolating Power Amplifiers for Parallel Transmit MRI

A radio frequency parallel transmitter was developed for magnetic resonance imaging. Eight channels of vector modulation and isolating power amplifiers were constructed so that the performance of different amplifier architectures could be investigated. An eight channel system was implemented and tested using both quantitative bench measurements and imaging experiments. The imaging experiments were performed on three separate MR systems at 3T, 4.7T, and 7T at different sites using both B1 shimming and fast modulation techniques. The modulation system implemented is based on vector modulators in order to simplify integration with existing MRI systems. Current Source and Low Output Impedance amplifiers were built and compared in terms of theory of operation, their ability to isolate array coils, and the amount of power they can deliver to a coil. The current source amplifiers function by introducing a high impedance in series with the coil which is series resonant. In contrast, the low output impedance amplifiers present a low impedance to the coil which has a matching network that forms a parallel resonant tank. Both are able to provide isolation, with the current source amplifiers producing in excess of 30dB of isolation and low output impedance amplifiers providing approximately 12.5dB in practical situations. The current source amplifiers can only produce approximately 10A (or between 150W and 300W) of output power because they are not power matched. In contrast, the low output impedance amplifiers can produce roughly 1kW (the device rating) because they are power matched. Ultimately, there is no single best architecture of power amplifiers at this time. Standard amplifiers are useful when only one or two transmit channels are needed and broad-bandedness is valuable. Current source amplifiers are best suited to situations where very high channel counts are needed because of their high isolation. Low output impedance amplifiers are most useful with moderate channel counts because they provide some isolation at moderately high powers

Transmit field pattern control for high field magnetic resonance imaging with integrated RF current sources

The primary design criterion for RF transmit coils for MRI is uniform transverse magnetic (B1) field. Currently, most high frequency transmit coils are designed as periodic, symmetric structures that are resonant at the imaging frequency, as determined by the static magnetic (B0) field strength. These coils are excited by one or more voltage sources. The distribution of currents on the coil elements or rungs is determined by the symmetry of the coil structure. At field strengths of 3T and above, electric properties such as the dielectric constant and conductivity of the load lead to B1 field inhomogeneity due to wavelength effects and perturbation of the coil current distribution from the ideal. The B1 field homogeneity under such conditions may be optimized by adjusting the amplitudes and phases of the currents on the rungs. However, such adjustments require independent control of current amplitudes and phases on each rung of the resonant coil. Due to both the strong coupling among the rungs of a resonant coil and the sensitivity to loading, such independent control would not be possible and B1 homogeneity optimization would involve a time consuming and impractical iterative procedure in the absence of exact knowledge of interactions among coil elements and between the coil and load. This dissertation is based on the work done towards the design and development of a RF current source that drives high amplitude RF current through an integrated array element. The arrangement is referred to as a current element. Independent control of current amplitude and phase on the current elements is demonstrated. A non-resonant coil structure consisting of current elements is implemented and B1 field pattern control is demonstrated. It is therefore demonstrated that this technology would enable effective B1 field optimization in the presence of lossy dielectric loads at high field strengths

A Novel Power-Efficient Wireless Multi-channel Recording System for the Telemonitoring of Electroencephalography (EEG)

This research introduces the development of a novel EEG recording system that is modular, batteryless, and wireless (untethered) with the supporting theoretical foundation in wireless communications and related design elements and circuitry. Its modular construct overcomes the EEG scaling problem and makes it easier for reconfiguring the hardware design in terms of the number and placement of electrodes and type of standard EEG system contemplated for use. In this development, portability, lightweight, and applicability to other clinical applications that rely on EEG data are sought. Due to printer tolerance, the 3D printed cap consists of 61 electrode placements. This recording capacity can however extend from 21 (as in the international 10-20 systems) up to 61 EEG channels at sample rates ranging from 250 to 1000 Hz and the transfer of the raw EEG signal using a standard allocated frequency as a data carrier. The main objectives of this dissertation are to (1) eliminate the need for heavy mounted batteries, (2) overcome the requirement for bulky power systems, and (3) avoid the use of data cables to untether the EEG system from the subject for a more practical and less restrictive setting. Unpredictability and temporal variations of the EEG input make developing a battery-free and cable-free EEG reading device challenging. Professional high-quality and high-resolution analog front ends are required to capture non-stationary EEG signals at microvolt levels. The primary components of the proposed setup are the wireless power transmission unit, which consists of a power amplifier, highly efficient resonant-inductive link, rectification, regulation, and power management units, as well as the analog front end, which consists of an analog to digital converter, pre-amplification unit, filtering unit, host microprocessor, and the wireless communication unit. These must all be compatible with the rest of the system and must use the least amount of power possible while minimizing the presence of noise and the attenuation of the recorded signal A highly efficient resonant-inductive coupling link is developed to decrease power transmission dissipation. Magnetized materials were utilized to steer electromagnetic flux and decrease route and medium loss while transmitting the required energy with low dissipation. Signal pre-amplification is handled by the front-end active electrodes. Standard bio-amplifier design approaches are combined to accomplish this purpose, and a thorough investigation of the optimum ADC, microcontroller, and transceiver units has been carried out. We can minimize overall system weight and power consumption by employing battery-less and cable-free EEG readout system designs, consequently giving patients more comfort and freedom of movement. Similarly, the solutions are designed to match the performance of medical-grade equipment. The captured electrical impulses using the proposed setup can be stored for various uses, including classification, prediction, 3D source localization, and for monitoring and diagnosing different brain disorders. All the proposed designs and supporting mathematical derivations were validated through empirical and software-simulated experiments. Many of the proposed designs, including the 3D head cap, the wireless power transmission unit, and the pre-amplification unit, are already fabricated, and the schematic circuits and simulation results were based on Spice, Altium, and high-frequency structure simulator (HFSS) software. The fully integrated head cap to be fabricated would require embedding the active electrodes into the 3D headset and applying current technological advances to miniaturize some of the design elements developed in this dissertation

Practical design of multi-channel MOSFETRF transmission system for 7 T animal MR imaging

In this work, we developed and tested a multi-channel radio frequency (RF) transmission system with compact metal-oxide semiconductor field effect transistor (MOSFET) amplifiers for parallel excitation in 7 T animal MRI scanner. The system is composed of a multi-channel RF controller and four independent RF power amplifiers. Each power amplifier contains two amplification stages. The design was validated by simulation and bench test. The power gain for the amplifier is 18.7 dB at 300 MHz, demonstrating the sufficient amplification capability of the transmission system for small animal parallel excitation applications at 7 T. This compact RF power amplifier can be potentially used for on-coil amplification in multichannel RF array system

Loop radiofrequency coils for clinical magnetic resonance imaging at 7 TESLA

To date, the 7 T magnetic resonance imaging (MRI) scanner remains a pure research system and there is still a long way ahead till full clinical integration. Key challenges are the absence of a body transmit radiofrequency (RF) coil as well as of dedicated RF coils in general, short RF wavelengths of the excitation field in the order of the dimensions of a human body leading to signal inhomogeneities, and severe limitations with respect to the specific absorption rate. They all result in a strong need for RF engineering and sequence optimization to explore the potential of MRI at 7 T, and to pave the way for its future clinical application. In this thesis, high-resolution MRI with a rather small field-of-view (FOV) in the head and neck region (parotid gland/duct and carotid arteries), and of the musculoskeletal system as well as with a very large FOV in the abdomen (spine) were presented. Therefore, a variety of RF coils were used: from a commercially available single-loop coil to novel, specially developed phased array coils each consisting of eight loop elements. Methods to thoroughly characterize and test the developed RF coils were presented, including numerical simulations, bench and MRI measurements. Characterization with respect to performance for parallel acquisition techniques and an extensive compliance testing for patient safety were described in detail. All aspects of the engineering part, from design to optimization, and finally, to the in vivo application in volunteers and patients were covered. Since clinical applicability has always been the purpose, optimized imaging protocols along with a discussion on the clinical relevance was included in each study. The presented RF loop coils widely expand the options for clinical research at 7 T and advance the integration of this technology in a clinical setting

Efficient and Linear CMOS Power Amplifier and Front-end Design for Broadband Fully-Integrated 28-GHz 5G Phased Arrays

Demand for data traffic on mobile networks is growing exponentially with time and on a global scale. The emerging fifth-generation (5G) wireless standard is being developed with millimeter-wave (mm-Wave) links as a key technological enabler to address this growth by a 2020 time frame. The wireless industry is currently racing to deploy mm-Wave mobile services, especially in the 28-GHz band. Previous widely-held perceptions of fundamental propagation limitations were overcome using phased arrays. Equally important for success of 5G is the development of low-power, broadband user equipment (UE) radios in commercial-grade technologies. This dissertation demonstrates design methodologies and circuit techniques to tackle the critical challenge of key phased array front-end circuits in low-cost complementary metal oxide semiconductor (CMOS) technology. Two power amplifier (PA) proof-of-concept prototypes are implemented in deeply scaled 28- nm and 40-nm CMOS processes, demonstrating state-of-the-art linearity and efficiency for extremely broadband communication signals. Subsequently, the 40 nm PA design is successfully embedded into a low-power fully-integrated transmit-receive front-end module. The 28 nm PA prototype in this dissertation is the first reported linear, bulk CMOS PA targeting low-power 5G mobile UE integrated phased array transceivers. An optimization methodology is presented to maximizing power added efficiency (PAE) in the PA output stage at a desired error vector magnitude (EVM) and range to address challenging 5G uplink requirements. Then, a source degeneration inductor in the optimized output stage is shown to further enable its embedding into a two-stage transformer-coupled PA. The inductor helps by broadening inter-stage impedance matching bandwidth, and helping to reduce distortion. Designed and fabricated in 1P7M 28 nm bulk CMOS and using a 1 V supply, the PA achieves +4.2 dBm/9% measured Pout/PAE at −25 dBc EVM for a 250 MHz-wide, 64-QAM orthogonal frequency division multiplexing (OFDM) signal with 9.6 dB peak-to-average power ratio (PAPR). The PA also achieves 35.5%/10% PAE for continuous wave signals at saturation/9.6dB back-off from saturation. To the best of the author’s knowledge, these are the highest measured PAE values among published K- and K a-band CMOS PAs to date. To drastically extend the communication bandwidth in 28 GHz-band UE devices, and to explore the potential of CMOS technology for more demanding access point (AP) devices, the second PA is demonstrated in a 40 nm process. This design supports a signal radio frequency bandwidth (RFBW) >3× the state-of-the-art without degrading output power (i.e. range), PAE (i.e. battery life), or EVM (i.e. amplifier fidelity). The three-stage PA uses higher-order, dual-resonance transformer matching networks with bandwidths optimized for wideband linearity. Digital gain control of 9 dB range is integrated for phased array operation. The gain control is a needed functionality, but it is largely absent from reported high-performance mm-Wave PAs in the literature. The PA is fabricated in a 1P6M 40 nm CMOS LP technology with 1.1 V supply, and achieves Pout/PAE of +6.7 dBm/11% for an 8×100 MHz carrier aggregation 64-QAM OFDM signal with 9.7 dB PAPR. This PA therefore is the first to demonstrate the viability of CMOS technology to address even the very challenging 5G AP/downlink signal bandwidth requirement. Finally, leveraging the developed PA design methodologies and circuits, a low power transmit-receive phased array front-end module is fully integrated in 40 nm technology. In transmit-mode, the front-end maintains the excellent performance of the 40 nm PA: achieving +5.5 dBm/9% for the same 8×100 MHz carrier aggregation signal above. In receive-mode, a 5.5 dB noise figure (NF) and a minimum third-order input intercept point (IIP₃) of −13 dBm are achieved. The performance of the implemented CMOS frontend is comparable to state-of-the-art publications and commercial products that were very recently developed in silicon germanium (SiGe) technologies for 5G communication