Combining Context and Knowledge Representations for Chemical-Disease Relation Extraction

Automatically extracting the relationships between chemicals and diseases is significantly important to various areas of biomedical research and health care. Biomedical experts have built many large-scale knowledge bases (KBs) to advance the development of biomedical research. KBs contain huge amounts of structured information about entities and relationships, therefore plays a pivotal role in chemical-disease relation (CDR) extraction. However, previous researches pay less attention to the prior knowledge existing in KBs. This paper proposes a neural network-based attention model (NAM) for CDR extraction, which makes full use of context information in documents and prior knowledge in KBs. For a pair of entities in a document, an attention mechanism is employed to select important context words with respect to the relation representations learned from KBs. Experiments on the BioCreative V CDR dataset show that combining context and knowledge representations through the attention mechanism, could significantly improve the CDR extraction performance while achieve comparable results with state-of-the-art systems.Comment: Published on IEEE/ACM Transactions on Computational Biology and Bioinformatics, 11 pages, 5 figure

Site-Specific Rules Extraction in Precision Agriculture

El incremento sostenible en la producción alimentaria para satisfacer las necesidades de una población mundial en aumento es un verdadero reto cuando tenemos en cuenta el impacto constante de plagas y enfermedades en los cultivos. Debido a las importantes pérdidas económicas que se producen, el uso de tratamientos químicos es demasiado alto; causando contaminación del medio ambiente y resistencia a distintos tratamientos. En este contexto, la comunidad agrícola divisa la aplicación de tratamientos más específicos para cada lugar, así como la validación automática con la conformidad legal. Sin embargo, la especificación de estos tratamientos se encuentra en regulaciones expresadas en lenguaje natural. Por este motivo, traducir regulaciones a una representación procesable por máquinas está tomando cada vez más importancia en la agricultura de precisión.Actualmente, los requisitos para traducir las regulaciones en reglas formales están lejos de ser cumplidos; y con el rápido desarrollo de la ciencia agrícola, la verificación manual de la conformidad legal se torna inabordable.En esta tesis, el objetivo es construir y evaluar un sistema de extracción de reglas para destilar de manera efectiva la información relevante de las regulaciones y transformar las reglas de lenguaje natural a un formato estructurado que pueda ser procesado por máquinas. Para ello, hemos separado la extracción de reglas en dos pasos. El primero es construir una ontología del dominio; un modelo para describir los desórdenes que producen las enfermedades en los cultivos y sus tratamientos. El segundo paso es extraer información para poblar la ontología. Puesto que usamos técnicas de aprendizaje automático, implementamos la metodología MATTER para realizar el proceso de anotación de regulaciones. Una vez creado el corpus, construimos un clasificador de categorías de reglas que discierne entre obligaciones y prohibiciones; y un sistema para la extracción de restricciones en reglas, que reconoce información relevante para retener el isomorfismo con la regulación original. Para estos componentes, empleamos, entre otra técnicas de aprendizaje profundo, redes neuronales convolucionales y “Long Short- Term Memory”. Además, utilizamos como baselines algoritmos más tradicionales como “support-vector machines” y “random forests”.Como resultado, presentamos la ontología PCT-O, que ha sido alineada con otras ontologías como NCBI, PubChem, ChEBI y Wikipedia. El modelo puede ser utilizado para la identificación de desórdenes, el análisis de conflictos entre tratamientos y la comparación entre legislaciones de distintos países. Con respecto a los sistemas de extracción, evaluamos empíricamente el comportamiento con distintas métricas, pero la métrica F1 es utilizada para seleccionar los mejores sistemas. En el caso del clasificador de categorías de reglas, el mejor sistema obtiene un macro F1 de 92,77% y un F1 binario de 85,71%. Este sistema usa una red “bidirectional long short-term memory” con “word embeddings” como entrada. En relación al extractor de restricciones de reglas, el mejor sistema obtiene un micro F1 de 88,3%. Este extractor utiliza como entrada una combinación de “character embeddings” junto a “word embeddings” y una red neuronal “bidirectional long short-term memory”.<br /

Knowledge-based Biomedical Data Science 2019

Knowledge-based biomedical data science (KBDS) involves the design and implementation of computer systems that act as if they knew about biomedicine. Such systems depend on formally represented knowledge in computer systems, often in the form of knowledge graphs. Here we survey the progress in the last year in systems that use formally represented knowledge to address data science problems in both clinical and biological domains, as well as on approaches for creating knowledge graphs. Major themes include the relationships between knowledge graphs and machine learning, the use of natural language processing, and the expansion of knowledge-based approaches to novel domains, such as Chinese Traditional Medicine and biodiversity.Comment: Manuscript 43 pages with 3 tables; Supplemental material 43 pages with 3 table

Concept graphs: Applications to biomedical text categorization and concept extraction

As science advances, the underlying literature grows rapidly providing valuable knowledge mines for researchers and practitioners. The text content that makes up these knowledge collections is often unstructured and, thus, extracting relevant or novel information could be nontrivial and costly. In addition, human knowledge and expertise are being transformed into structured digital information in the form of vocabulary databases and ontologies. These knowledge bases hold substantial hierarchical and semantic relationships of common domain concepts. Consequently, automating learning tasks could be reinforced with those knowledge bases through constructing human-like representations of knowledge. This allows developing algorithms that simulate the human reasoning tasks of content perception, concept identification, and classification. This study explores the representation of text documents using concept graphs that are constructed with the help of a domain ontology. In particular, the target data sets are collections of biomedical text documents, and the domain ontology is a collection of predefined biomedical concepts and relationships among them. The proposed representation preserves those relationships and allows using the structural features of graphs in text mining and learning algorithms. Those features emphasize the significance of the underlying relationship information that exists in the text content behind the interrelated topics and concepts of a text document. The experiments presented in this study include text categorization and concept extraction applied on biomedical data sets. The experimental results demonstrate how the relationships extracted from text and captured in graph structures can be used to improve the performance of the aforementioned applications. The discussed techniques can be used in creating and maintaining digital libraries through enhancing indexing, retrieval, and management of documents as well as in a broad range of domain-specific applications such as drug discovery, hypothesis generation, and the analysis of molecular structures in chemoinformatics

CREATE: Concept Representation and Extraction from Heterogeneous Evidence

Traditional information retrieval methodology is guided by document retrieval paradigm, where relevant documents are returned in response to user queries. This paradigm faces serious drawback if the desired result is not explicitly present in a single document. The problem becomes more obvious when a user tries to obtain complete information about a real world entity, such as person, company, location etc. In such cases, various facts about the target entity or concept need to be gathered from multiple document sources. In this work, we present a method to extract information about a target entity based on the concept retrieval paradigm that focuses on extracting and blending information related to a concept from multiple sources if necessary. The paradigm is built around a generic notion of concept which is defined as any item that can be thought of as a topic of interest. Concepts may correspond to any real world entity such as restaurant, person, city, organization, etc, or any abstract item such as news topic, event, theory, etc. Web is a heterogeneous collection of data in different forms such as facts, news, opinions etc. We propose different models for different forms of data, all of which work towards the same goal of concept centric retrieval. We motivate our work based on studies about current trends and demands for information seeking. The framework helps in understanding the intent of content, i.e. opinion versus fact. Our work has been conducted on free text data in English. Nevertheless, our framework can be easily transferred to other languages

GNTeam at 2018 n2c2:Feature-augmented BiLSTM-CRF for drug-related entity recognition in hospital discharge summaries

Monitoring the administration of drugs and adverse drug reactions are key parts of pharmacovigilance. In this paper, we explore the extraction of drug mentions and drug-related information (reason for taking a drug, route, frequency, dosage, strength, form, duration, and adverse events) from hospital discharge summaries through deep learning that relies on various representations for clinical named entity recognition. This work was officially part of the 2018 n2c2 shared task, and we use the data supplied as part of the task. We developed two deep learning architecture based on recurrent neural networks and pre-trained language models. We also explore the effect of augmenting word representations with semantic features for clinical named entity recognition. Our feature-augmented BiLSTM-CRF model performed with F1-score of 92.67% and ranked 4th for entity extraction sub-task among submitted systems to n2c2 challenge. The recurrent neural networks that use the pre-trained domain-specific word embeddings and a CRF layer for label optimization perform drug, adverse event and related entities extraction with micro-averaged F1-score of over 91%. The augmentation of word vectors with semantic features extracted using available clinical NLP toolkits can further improve the performance. Word embeddings that are pre-trained on a large unannotated corpus of relevant documents and further fine-tuned to the task perform rather well. However, the augmentation of word embeddings with semantic features can help improve the performance (primarily by boosting precision) of drug-related named entity recognition from electronic health records

Automatic extraction of concepts from texts and applications

The extraction of relevant terms from texts is an extensively researched task in Text- Mining. Relevant terms have been applied in areas such as Information Retrieval or document clustering and classification. However, relevance has a rather fuzzy nature since the classification of some terms as relevant or not relevant is not consensual. For instance, while words such as "president" and "republic" are generally considered relevant by human evaluators, and words like "the" and "or" are not, terms such as "read" and "finish" gather no consensus about their semantic and informativeness. Concepts, on the other hand, have a less fuzzy nature. Therefore, instead of deciding on the relevance of a term during the extraction phase, as most extractors do, I propose to first extract, from texts, what I have called generic concepts (all concepts) and postpone the decision about relevance for downstream applications, accordingly to their needs. For instance, a keyword extractor may assume that the most relevant keywords are the most frequent concepts on the documents. Moreover, most statistical extractors are incapable of extracting single-word and multi-word expressions using the same methodology. These factors led to the development of the ConceptExtractor, a statistical and language-independent methodology which is explained in Part I of this thesis. In Part II, I will show that the automatic extraction of concepts has great applicability. For instance, for the extraction of keywords from documents, using the Tf-Idf metric only on concepts yields better results than using Tf-Idf without concepts, specially for multi-words. In addition, since concepts can be semantically related to other concepts, this allows us to build implicit document descriptors. These applications led to published work. Finally, I will present some work that, although not published yet, is briefly discussed in this document.Fundação para a Ciência e a Tecnologia - SFRH/BD/61543/200