Hepatitis C virus related cirrhosis decreased as indication to liver transplantation since the introduction of direct-acting antivirals: A single-center study

AIM: To evaluate waiting list (WL) registration and liver transplantation (LT) rates in patients with hepatitis C virus (HCV)-related cirrhosis since the introduction of direct-acting antivirals (DAAs). METHODS: All adult patients with cirrhosis listed for LT at Padua University Hospital between 2006-2017 were retrospectively collected using a prospectively-updated database; patients with HCV-related cirrhosis were divided by indication for LT [dec-HCV vs HCV/ hepatocellular carcinoma (HCC)] and into two interval times (2006-2013 and 2014-2017) according to the introduction of DAAs. For each patient, indications to LT, severity of liver dysfunction and the outcome in the WL were assessed and compared between the two different time periods. For patients receiving DAA-based regimens, the achievement of viral eradication and the outcome were also evaluated. RESULTS: One thousand one hundred and ninty-four [male (M)/female (F): 925/269] patients were included. Considering the whole cohort, HCV-related cirrhosis was the main etiology at the time of WL registration (490/1194 patients, 41%). HCV-related cirrhosis significantly decreased as indication to WL registration after DAA introduction (from 43.3% in 2006-2013 to 37.2% in 2014-2017, P = 0.05), especially amongst dec-HCV (from 24.2% in 2006-2013 to 15.9% in 2014-2017, P = 0.007). Even HCV remained the most common indication to LT over time (289/666, 43.4%), there was a trend towards a decrease after DAAs introduction (from 46.3% in 2006-2013 to 39% in 2014-2017, P = 0.06). HCV patients (M/F: 43/11, mean age: 57.7 \ub1 8 years) who achieved viral eradication in the WL had better transplant-free survival (log-rank test P = 0.02) and delisting rate (P = 0.002) than untreated HCV patients. CONCLUSION: Introduction of DAAs significantly reduced WL registrations for HCV related cirrhosis, especially in the setting of decompensated cirrhosis

Whatever Happened to Military Good Order and Discipline?

Discipline is often called “the soul of an army.” If this is so, the United States military seems to be experiencing a spiritual crisis. Article 134 of the Uniform Code of Military Justice (UCMJ) allows commanders to punish acts prejudicial to “good order and discipline,” but the reach of this provision has been increasingly limited in recent years. Appellate courts have repeatedly overturned convictions of conduct charged as prejudicial to good order and discipline, and in recent years, the military’s high court has issued a series of decisions limiting the reach of the UCMJ’s “general article.” Congress has also recently acted to dramatically scale back the scope of Article 134. The result is that while military leaders might talk about the criticality of maintaining good order and discipline, commanders’ authority to actually punish behavior that detracts from good order and discipline is increasingly constrained. This Article ties the developments regarding Article 134 to a larger issue: the difficulty the military has demonstrated in defining what “good order and discipline” actually means. The term lacks an agreed-upon definition, and the military has not explored how changes in society and the military mission affect the term’s meaning. In a series of policy reforms in recent decades, military leaders have generally cited “good order and discipline” as a basis for their opposition without defining the term or substantively exploring this concept. These reforms were ultimately enacted over military leaders’ objections without any apparent impact on good order and discipline. As a result, Congress and the media have grown increasingly wary of the good order and discipline term, diminishing its rhetorical weight. The military must take a more orderly, disciplined approach to defining this term, and this Article proposes a definition as a first step toward igniting this discussion

Transforming Military Justice: The 2022 and 2023 National Defense Authorization Acts

For the past decade there have been numerous and significant changes to the Uniform Code of Military Justice (UCMJ), the statutory basis for the military justice system. Although the Military Justice Act of 2016 made major changes to the UCMJ, the calls for change continued. One of the most-often heard calls for reform over the last decade has suggested removing commanders from the military justice system. Some have argued that a command-centric military justice system was outdated, and it was time to make the system look more like the federal criminal procedure system. Other critics have advocated for a military justice system that looks more like those of our allied nations. In large part, those calls for reform were driven by the seemingly intractable problem of sexual assaults in the military. While there were other proposed changes to the UCMJ, calls for reducing the role of the commander took the lead

Transforming Military Justice: The 2022 and 2023 National Defense Authorization Acts

For the past decade there have been numerous and significant changes to the Uniform Code of Military Justice (UCMJ), the statutory basis for the military justice system. Although the Military Justice Act of 2016 made major changes to the UCMJ, the calls for change continued. One of the most-often heard calls for reform over the last decade has suggested removing commanders from the military justice system. Some have argued that a command-centric military justice system was outdated, and it was time to make the system look more like the federal criminal procedure system. Other critics have advocated for a military justice system that looks more like those of our allied nations. In large part, those calls for reform were driven by the seemingly intractable problem of sexual assaults in the military. While there were other proposed changes to the UCMJ, calls for reducing the role of the commander took the lead

Advances in Polar Materials for Lithium-Sulfur Batteries

Lithium-sulfur batteries are regarded as promising candidates for energy storage devices due to their high theoretical energy density. Various approaches are proposed to break through the obstacles that are preventing Li-S batteries from realizing practical application. Recently, the importance of the strong chemical interaction between polar materials and polysulfides is recognized by researchers to improve the performance of Li-S batteries, especially with respect to the shuttle effect. Polar materials, unlike nonpolar materials, exhibit strong interactions with polysulfides without any modification or doping because of their intrinsic polarity, absorbing the polar polysulfides and thus suppressing the notorious shuttle effect. The recent advances on polar materials for Li-S batteries are reviewed here, especially the chemical polar-polar interaction effects toward immobilizing dissolved polysulfides, and the relationship between the intrinsic properties of the polar materials and the electrochemical performance of the Li-S batteries are discussed. Polar materials, including polar inorganics in the cathode and polar organics as binder for the Li-S batteries are respectively described. Finally, future directions and prospects for the polar materials used in Li-S batteries are also proposed

Nanoporous Materials and Their Applications

This book is a special collection of articles dedicated to the preparation and characterization of nanoporous materials, such as zeolitic-type materials, mesoporous silica (SBA-15, MCM-41, and KIT-6), mesoporous metallic oxides, metal–organic framework structures (MOFs), and pillared clays, and their applications in adsorption, catalysis, and separation processes. This book presents a global vision of researchers from international universities, research centers, and industries working with nanoporous materials and shares the latest results on the synthesis and characterization of such materials, which have given rise to the special interest in their applications in basic and industrial processes

Modern Military Justice: Cases and Materials

This textbook is about the modern military justice system of the United States. It covers court-martial procedures, substantive criminal law, and nonjudicial punishment under the Uniform Code of Military Justice, in addition to the Military Extraterritorial Jurisdiction Act, which gives federal courts jurisdiction over certain acts committed abroad. The Third Edition includes several recent cases and updates that address the significant changes made in the 2019 Manual for Courts-Martial, the Military Justice Act of 2016, and other recent legislation

Waveform Design for 5G and beyond Systems

5G traffic has very diverse requirements with respect to data rate, delay, and reliability. The concept of using multiple OFDM numerologies adopted in the 5G NR standard will likely meet these multiple requirements to some extent. However, the traffic is radically accruing different characteristics and requirements when compared with the initial stage of 5G, which focused mainly on high-speed multimedia data applications. For instance, applications such as vehicular communications and robotics control require a highly reliable and ultra-low delay. In addition, various emerging M2M applications have sparse traffic with a small amount of data to be delivered. The state-of-the-art OFDM technique has some limitations when addressing the aforementioned requirements at the same time. Meanwhile, numerous waveform alternatives, such as FBMC, GFDM, and UFMC, have been explored. They also have their own pros and cons due to their intrinsic waveform properties. Hence, it is the opportune moment to come up with modification/variations/combinations to the aforementioned techniques or a new waveform design for 5G systems and beyond. The aim of this Special Issue is to provide the latest research and advances in the field of waveform design for 5G systems and beyond

Development of Polyethylenimine (PEI)-impregnated mesoporous carbon spheres for low-concentration CO2 capture

A novel low-concentration CO2 capture material (PEI/MCS) was developed by loading polyethylenimine (PEI) over mesoporous carbon spheres (MCS) with high porosity. The effects of pore structure, PEI loading, capture temperature, and promoters on CO2 capture of PEI/MCS were studied. The MCS with perfect spherical morphology was successfully synthesized by a hard-template assisted reverse emulsion method. The pore structure of MCS was adjusted by tuning the ratio of silica to carbon (Si/C) in the precursors. With increasing the Si/C from 0.8 to 1.1, the pore volume of MCS increased from 1.25 to 2.68 cm3/g. The optimal PEI loadings depending on the pore volume of MCS were 45, 62.5, and 65 wt.% for MCS-0.8, MCS-1.1, and MCS-1.5, respectively. The highest CO2 capture capacity (3.22 mmol/g) was achieved on 62.5PEI/MCS-1.1 at CO2 partial pressure of 0.05 bar (5 vol.%, a typical concentration of the tail gas from natural gas power plant and natural gas processing plant) and temperature of 75 °C, outperforming most of the solid amine sorbents reported at similar condition. However, the cycling stability of PEI/MCS is poor at the capture-regeneration temperature of 75 °C. The promoters Span 80 and 1,2-epoxybutane did not show remarkable effect on the cycling stability of PEI/MCS at 75 °C. Decreasing the capture-regeneration temperature can significantly improve the stability of PEI/MCS and there is almost no CO2 capacity loss (regeneration >99.5 %) when the temperature decreased to 50 °C. As a result of high CO2 capacity and excellent regenerability and stability, PEI /MCS will be one of the ideal candidates for CO2 capture in the future.acceptedVersio