Variational models for color image correction inspired by visual perception and neuroscience

Reproducing the perception of a real-world scene on a display device is a very challenging task which requires the understanding of the camera processing pipeline, the display process, and the way the human visual system processes the light it captures. Mathematical models based on psychophysical and physiological laws on color vision, named Retinex, provide efficient tools to handle degradations produced during the camera processing pipeline like the reduction of the contrast. In particular, Batard and Bertalmío [J Math. Imag. Vis. 60(6), 849-881 (2018)] described some psy-chophysical laws on brightness perception as covariant derivatives, included them into a variational model, and observed that the quality of the color image correction is correlated with the accuracy of the vision model it includes. Based on this observation, we postulate that this model can be improved by including more accurate data on vision with a special attention on visual neuro-science here. Then, inspired by the presence of neurons responding to different visual attributes in the area V1 of the visual cortex as orientation, color or movement, to name a few, and horizontal connections modeling the interactions between those neurons, we construct two variational models to process both local (edges, textures) and global (contrast) features. This is an improvement with respect to the model of Batard and Bertalmío as the latter can not process local and global features independently and simultaneously. Finally, we conduct experiments on color images which corroborate the improvement provided by the new models

Combining local regularity estimation and total variation optimization for scale-free texture segmentation

Texture segmentation constitutes a standard image processing task, crucial to many applications. The present contribution focuses on the particular subset of scale-free textures and its originality resides in the combination of three key ingredients: First, texture characterization relies on the concept of local regularity ; Second, estimation of local regularity is based on new multiscale quantities referred to as wavelet leaders ; Third, segmentation from local regularity faces a fundamental bias variance trade-off: In nature, local regularity estimation shows high variability that impairs the detection of changes, while a posteriori smoothing of regularity estimates precludes from locating correctly changes. Instead, the present contribution proposes several variational problem formulations based on total variation and proximal resolutions that effectively circumvent this trade-off. Estimation and segmentation performance for the proposed procedures are quantified and compared on synthetic as well as on real-world textures

Contributions of Continuous Max-Flow Theory to Medical Image Processing

Discrete graph cuts and continuous max-flow theory have created a paradigm shift in many areas of medical image processing. As previous methods limited themselves to analytically solvable optimization problems or guaranteed only local optimizability to increasingly complex and non-convex functionals, current methods based now rely on describing an optimization problem in a series of general yet simple functionals with a global, but non-analytic, solution algorithms. This has been increasingly spurred on by the availability of these general-purpose algorithms in an open-source context. Thus, graph-cuts and max-flow have changed every aspect of medical image processing from reconstruction to enhancement to segmentation and registration. To wax philosophical, continuous max-flow theory in particular has the potential to bring a high degree of mathematical elegance to the field, bridging the conceptual gap between the discrete and continuous domains in which we describe different imaging problems, properties and processes. In Chapter 1, we use the notion of infinitely dense and infinitely densely connected graphs to transfer between the discrete and continuous domains, which has a certain sense of mathematical pedantry to it, but the resulting variational energy equations have a sense of elegance and charm. As any application of the principle of duality, the variational equations have an enigmatic side that can only be decoded with time and patience. The goal of this thesis is to show the contributions of max-flow theory through image enhancement and segmentation, increasing incorporation of topological considerations and increasing the role played by user knowledge and interactivity. These methods will be rigorously grounded in calculus of variations, guaranteeing fuzzy optimality and providing multiple solution approaches to addressing each individual problem

Decomposition Ascribed Synergistic Learning for Unified Image Restoration

Learning to restore multiple image degradations within a single model is quite beneficial for real-world applications. Nevertheless, existing works typically concentrate on regarding each degradation independently, while their relationship has been less exploited to ensure the synergistic learning. To this end, we revisit the diverse degradations through the lens of singular value decomposition, with the observation that the decomposed singular vectors and singular values naturally undertake the different types of degradation information, dividing various restoration tasks into two groups,\ie, singular vector dominated and singular value dominated. The above analysis renders a more unified perspective to ascribe the diverse degradations, compared to previous task-level independent learning. The dedicated optimization of degraded singular vectors and singular values inherently utilizes the potential relationship among diverse restoration tasks, attributing to the Decomposition Ascribed Synergistic Learning (DASL). Specifically, DASL comprises two effective operators, namely, Singular VEctor Operator (SVEO) and Singular VAlue Operator (SVAO), to favor the decomposed optimization, which can be lightly integrated into existing convolutional image restoration backbone. Moreover, the congruous decomposition loss has been devised for auxiliary. Extensive experiments on blended five image restoration tasks demonstrate the effectiveness of our method, including image deraining, image dehazing, image denoising, image deblurring, and low-light image enhancement.Comment: 13 page

Dense Corresspondence Estimation for Image Interpolation

We evaluate the current state-of-the-art in dense correspondence estimation for the use in multi-image interpolation algorithms. The evaluation is carried out on three real-world scenes and one synthetic scene, each featuring varying challenges for dense correspondence estimation. The primary focus of our study is on the perceptual quality of the interpolation sequences created from the estimated flow fields. Perceptual plausibility is assessed by means of a psychophysical userstudy. Our results show that current state-of-the-art in dense correspondence estimation does not produce visually plausible interpolations.In diesem Bericht evaluieren wir den gegenwärtigen Stand der Technik in dichter Korrespondenzschätzung hinsichtlich der Eignung für die Nutzung in Algorithmen zur Zwischenbildsynthese. Die Auswertung erfolgt auf drei realen und einer synthetischen Szene mit variierenden Herausforderungen für Algorithmen zur Korrespondenzschätzung. Mittels einer perzeptuellen Benutzerstudie werten wir die wahrgenommene Qualität der interpolierten Bildsequenzen aus. Unsere Ergebnisse zeigen dass der gegenwärtige Stand der Technik in dichter Korrespondezschätzung nicht für die Zwischenbildsynthese geeignet ist

Meaningful Matches in Stereovision

This paper introduces a statistical method to decide whether two blocks in a pair of of images match reliably. The method ensures that the selected block matches are unlikely to have occurred "just by chance." The new approach is based on the definition of a simple but faithful statistical "background model" for image blocks learned from the image itself. A theorem guarantees that under this model not more than a fixed number of wrong matches occurs (on average) for the whole image. This fixed number (the number of false alarms) is the only method parameter. Furthermore, the number of false alarms associated with each match measures its reliability. This "a contrario" block-matching method, however, cannot rule out false matches due to the presence of periodic objects in the images. But it is successfully complemented by a parameterless "self-similarity threshold." Experimental evidence shows that the proposed method also detects occlusions and incoherent motions due to vehicles and pedestrians in non simultaneous stereo.Comment: IEEE Transactions on Pattern Analysis and Machine Intelligence 99, Preprints (2011) 1-1

Estimating and understanding motion : from diagnostic to robotic surgery

Estimating and understanding motion from an image sequence is a central topic in computer vision. The high interest in this topic is because we are living in a world where many events that occur in the environment are dynamic. This makes motion estimation and understanding a natural component and a key factor in a widespread of applications including object recognition , 3D shape reconstruction, autonomous navigation and medica! diagnosis. Particularly, we focus on the medical domain in which understanding the human body for clinical purposes requires retrieving the organs' complex motion patterns, which is in general a hard problem when using only image data. In this thesis, we cope with this problem by posing the question - How to achieve a realistic motion estimation to offer a better clinical understanding? We focus this thesis on answering this question by using a variational formulation as a basis to understand one of the most complex motions in the human's body, the heart motion, through three different applications: (i) cardiac motion estimation for diagnostic, (ii) force estimation and (iii) motion prediction, both for robotic surgery. Firstly, we focus on a central topic in cardiac imaging that is the estimation of the cardiac motion. The main aim is to offer objective and understandable measures to physicians for helping them in the diagnostic of cardiovascular diseases. We employ ultrafast ultrasound data and tools for imaging motion drawn from diverse areas such as low-rank analysis and variational deformation to perform a realistic cardiac motion estimation. The significance is that by taking low-rank data with carefully chosen penalization, synergies in this complex variational problem can be created. We demonstrate how our proposed solution deals with complex deformations through careful numerical experiments using realistic and simulated data. We then move from diagnostic to robotic surgeries where surgeons perform delicate procedures remotely through robotic manipulators without directly interacting with the patients. As a result, they lack force feedback, which is an important primary sense for increasing surgeon-patient transparency and avoiding injuries and high mental workload. To solve this problem, we follow the conservation principies of continuum mechanics in which it is clear that the change in shape of an elastic object is directly proportional to the force applied. Thus, we create a variational framework to acquire the deformation that the tissues undergo due to an applied force. Then, this information is used in a learning system to find the nonlinear relationship between the given data and the applied force. We carried out experiments with in-vivo and ex-vivo data and combined statistical, graphical and perceptual analyses to demonstrate the strength of our solution. Finally, we explore robotic cardiac surgery, which allows carrying out complex procedures including Off-Pump Coronary Artery Bypass Grafting (OPCABG). This procedure avoids the associated complications of using Cardiopulmonary Bypass (CPB) since the heart is not arrested while performing the surgery on a beating heart. Thus, surgeons have to deal with a dynamic target that compromisetheir dexterity and the surgery's precision. To compensate the heart motion, we propase a solution composed of three elements: an energy function to estimate the 3D heart motion, a specular highlight detection strategy and a prediction approach for increasing the robustness of the solution. We conduct evaluation of our solution using phantom and realistic datasets. We conclude the thesis by reporting our findings on these three applications and highlight the dependency between motion estimation and motion understanding at any dynamic event, particularly in clinical scenarios.L’estimació i comprensió del moviment dins d’una seqüència d’imatges és un tema central en la visió per ordinador, el que genera un gran interès perquè vivim en un entorn ple d’esdeveniments dinàmics. Per aquest motiu és considerat com un component natural i factor clau dins d’un ampli ventall d’aplicacions, el qual inclou el reconeixement d’objectes, la reconstrucció de formes tridimensionals, la navegació autònoma i el diagnòstic de malalties. En particular, ens situem en l’àmbit mèdic en el qual la comprensió del cos humà, amb finalitats clíniques, requereix l’obtenció de patrons complexos de moviment dels òrgans. Aquesta és, en general, una tasca difícil quan s’utilitzen només dades de tipus visual. En aquesta tesi afrontem el problema plantejant-nos la pregunta - Com es pot aconseguir una estimació realista del moviment amb l’objectiu d’oferir una millor comprensió clínica? La tesi se centra en la resposta mitjançant l’ús d’una formulació variacional com a base per entendre un dels moviments més complexos del cos humà, el del cor, a través de tres aplicacions: (i) estimació del moviment cardíac per al diagnòstic, (ii) estimació de forces i (iii) predicció del moviment, orientant-se les dues últimes en cirurgia robòtica. En primer lloc, ens centrem en un tema principal en la imatge cardíaca, que és l’estimació del moviment cardíac. L’objectiu principal és oferir als metges mesures objectives i comprensibles per ajudar-los en el diagnòstic de les malalties cardiovasculars. Fem servir dades d’ultrasons ultraràpids i eines per al moviment d’imatges procedents de diverses àrees, com ara l’anàlisi de baix rang i la deformació variacional, per fer una estimació realista del moviment cardíac. La importància rau en que, en prendre les dades de baix rang amb una penalització acurada, es poden crear sinergies en aquest problema variacional complex. Mitjançant acurats experiments numèrics, amb dades realístiques i simulades, hem demostrat com les nostres propostes solucionen deformacions complexes. Després passem del diagnòstic a la cirurgia robòtica, on els cirurgians realitzen procediments delicats remotament, a través de manipuladors robòtics, sense interactuar directament amb els pacients. Com a conseqüència, no tenen la percepció de la força com a resposta, que és un sentit primari important per augmentar la transparència entre el cirurgià i el pacient, per evitar lesions i per reduir la càrrega de treball mental. Resolem aquest problema seguint els principis de conservació de la mecànica del medi continu, en els quals està clar que el canvi en la forma d’un objecte elàstic és directament proporcional a la força aplicada. Per això hem creat un marc variacional que adquireix la deformació que pateixen els teixits per l’aplicació d’una força. Aquesta informació s’utilitza en un sistema d’aprenentatge, per trobar la relació no lineal entre les dades donades i la força aplicada. Hem dut a terme experiments amb dades in-vivo i ex-vivo i hem combinat l’anàlisi estadístic, gràfic i de percepció que demostren la robustesa de la nostra solució. Finalment, explorem la cirurgia cardíaca robòtica, la qual cosa permet realitzar procediments complexos, incloent la cirurgia coronària sense bomba (off-pump coronary artery bypass grafting o OPCAB). Aquest procediment evita les complicacions associades a l’ús de circulació extracorpòria (Cardiopulmonary Bypass o CPB), ja que el cor no s’atura mentre es realitza la cirurgia. Això comporta que els cirurgians han de tractar amb un objectiu dinàmic que compromet la seva destresa i la precisió de la cirurgia. Per compensar el moviment del cor, proposem una solució composta de tres elements: un funcional d’energia per estimar el moviment tridimensional del cor, una estratègia de detecció de les reflexions especulars i una aproximació basada en mètodes de predicció, per tal d’augmentar la robustesa de la solució. L’avaluació de la nostra solució s’ha dut a terme mitjançant conjunts de dades sintètiques i realistes. La tesi conclou informant dels nostres resultats en aquestes tres aplicacions i posant de relleu la dependència entre l’estimació i la comprensió del moviment en qualsevol esdeveniment dinàmic, especialment en escenaris clínics.Postprint (published version

Natural image processing and synthesis using deep learning

Nous étudions dans cette thèse comment les réseaux de neurones profonds peuvent être utilisés dans différents domaines de la vision artificielle. La vision artificielle est un domaine interdisciplinaire qui traite de la compréhension d’images et de vidéos numériques. Les problèmes de ce domaine ont traditionnellement été adressés avec des méthodes ad-hoc nécessitant beaucoup de réglages manuels. En effet, ces systèmes de vision artificiels comprenaient jusqu’à récemment une série de modules optimisés indépendamment. Cette approche est très raisonnable dans la mesure où, avec peu de données, elle bénéficient autant que possible des connaissances du chercheur. Mais cette avantage peut se révéler être une limitation si certaines données d’entré n’ont pas été considérées dans la conception de l’algorithme. Avec des volumes et une diversité de données toujours plus grands, ainsi que des capacités de calcul plus rapides et économiques, les réseaux de neurones profonds optimisés d’un bout à l’autre sont devenus une alternative attrayante. Nous démontrons leur avantage avec une série d’articles de recherche, chacun d’entre eux trouvant une solution à base de réseaux de neurones profonds à un problème d’analyse ou de synthèse visuelle particulier. Dans le premier article, nous considérons un problème de vision classique: la détection de bords et de contours. Nous partons de l’approche classique et la rendons plus ‘neurale’ en combinant deux étapes, la détection et la description de motifs visuels, en un seul réseau convolutionnel. Cette méthode, qui peut ainsi s’adapter à de nouveaux ensembles de données, s’avère être au moins aussi précis que les méthodes conventionnelles quand il s’agit de domaines qui leur sont favorables, tout en étant beaucoup plus robuste dans des domaines plus générales. Dans le deuxième article, nous construisons une nouvelle architecture pour la manipulation d’images qui utilise l’idée que la majorité des pixels produits peuvent d’être copiés de l’image d’entrée. Cette technique bénéficie de plusieurs avantages majeurs par rapport à l’approche conventionnelle en apprentissage profond. En effet, elle conserve les détails de l’image d’origine, n’introduit pas d’aberrations grâce à la capacité limitée du réseau sous-jacent et simplifie l’apprentissage. Nous démontrons l’efficacité de cette architecture dans le cadre d’une tâche de correction du regard, où notre système produit d’excellents résultats. Dans le troisième article, nous nous éclipsons de la vision artificielle pour étudier le problème plus générale de l’adaptation à de nouveaux domaines. Nous développons un nouvel algorithme d’apprentissage, qui assure l’adaptation avec un objectif auxiliaire à la tâche principale. Nous cherchons ainsi à extraire des motifs qui permettent d’accomplir la tâche mais qui ne permettent pas à un réseau dédié de reconnaître le domaine. Ce réseau est optimisé de manière simultané avec les motifs en question, et a pour tâche de reconnaître le domaine de provenance des motifs. Cette technique est simple à implémenter, et conduit pourtant à l’état de l’art sur toutes les tâches de référence. Enfin, le quatrième article présente un nouveau type de modèle génératif d’images. À l’opposé des approches conventionnels à base de réseaux de neurones convolutionnels, notre système baptisé SPIRAL décrit les images en termes de programmes bas-niveau qui sont exécutés par un logiciel de graphisme ordinaire. Entre autres, ceci permet à l’algorithme de ne pas s’attarder sur les détails de l’image, et de se concentrer plutôt sur sa structure globale. L’espace latent de notre modèle est, par construction, interprétable et permet de manipuler des images de façon prévisible. Nous montrons la capacité et l’agilité de cette approche sur plusieurs bases de données de référence.In the present thesis, we study how deep neural networks can be applied to various tasks in computer vision. Computer vision is an interdisciplinary field that deals with understanding of digital images and video. Traditionally, the problems arising in this domain were tackled using heavily hand-engineered adhoc methods. A typical computer vision system up until recently consisted of a sequence of independent modules which barely talked to each other. Such an approach is quite reasonable in the case of limited data as it takes major advantage of the researcher's domain expertise. This strength turns into a weakness if some of the input scenarios are overlooked in the algorithm design process. With the rapidly increasing volumes and varieties of data and the advent of cheaper and faster computational resources end-to-end deep neural networks have become an appealing alternative to the traditional computer vision pipelines. We demonstrate this in a series of research articles, each of which considers a particular task of either image analysis or synthesis and presenting a solution based on a ``deep'' backbone. In the first article, we deal with a classic low-level vision problem of edge detection. Inspired by a top-performing non-neural approach, we take a step towards building an end-to-end system by combining feature extraction and description in a single convolutional network. The resulting fully data-driven method matches or surpasses the detection quality of the existing conventional approaches in the settings for which they were designed while being significantly more usable in the out-of-domain situations. In our second article, we introduce a custom architecture for image manipulation based on the idea that most of the pixels in the output image can be directly copied from the input. This technique bears several significant advantages over the naive black-box neural approach. It retains the level of detail of the original images, does not introduce artifacts due to insufficient capacity of the underlying neural network and simplifies training process, to name a few. We demonstrate the efficiency of the proposed architecture on the challenging gaze correction task where our system achieves excellent results. In the third article, we slightly diverge from pure computer vision and study a more general problem of domain adaption. There, we introduce a novel training-time algorithm (\ie, adaptation is attained by using an auxilliary objective in addition to the main one). We seek to extract features that maximally confuse a dedicated network called domain classifier while being useful for the task at hand. The domain classifier is learned simultaneosly with the features and attempts to tell whether those features are coming from the source or the target domain. The proposed technique is easy to implement, yet results in superior performance in all the standard benchmarks. Finally, the fourth article presents a new kind of generative model for image data. Unlike conventional neural network based approaches our system dubbed SPIRAL describes images in terms of concise low-level programs executed by off-the-shelf rendering software used by humans to create visual content. Among other things, this allows SPIRAL not to waste its capacity on minutae of datasets and focus more on the global structure. The latent space of our model is easily interpretable by design and provides means for predictable image manipulation. We test our approach on several popular datasets and demonstrate its power and flexibility

MANIFOLD REPRESENTATIONS OF MUSICAL SIGNALS AND GENERATIVE SPACES

Tra i diversi campi di ricerca nell\u2019ambito dell\u2019informatica musicale, la sintesi e la generazione di segnali audio incarna la pluridisciplinalita\u300 di questo settore, nutrendo insieme le pratiche scientifiche e musicale dalla sua creazione. Inerente all\u2019informatica dalla sua creazione, la generazione audio ha ispirato numerosi approcci, evolvendo colle pratiche musicale e gli progressi tecnologici e scientifici. Inoltre, alcuni processi di sintesi permettono anche il processo inverso, denominato analisi, in modo che i parametri di sintesi possono anche essere parzialmente o totalmente estratti dai suoni, dando una rappresentazione alternativa ai segnali analizzati. Per di piu\u300, la recente ascesa dei algoritmi di l\u2019apprendimento automatico ha vivamente interrogato il settore della ricerca scientifica, fornendo potenti data-centered metodi che sollevavano diversi epistemologici interrogativi, nonostante i sui efficacia. Particolarmente, un tipo di metodi di apprendimento automatico, denominati modelli generativi, si concentrano sulla generazione di contenuto originale usando le caratteristiche che hanno estratti dei dati analizzati. In tal caso, questi modelli non hanno soltanto interrogato i precedenti metodi di generazione, ma anche sul modo di integrare questi algoritmi nelle pratiche artistiche. Mentre questi metodi sono progressivamente introdotti nel settore del trattamento delle immagini, la loro applicazione per la sintesi di segnali audio e ancora molto marginale. In questo lavoro, il nostro obiettivo e di proporre un nuovo metodo di audio sintesi basato su questi nuovi tipi di generativi modelli, rafforazti dalle nuove avanzati dell\u2019apprendimento automatico. Al primo posto, facciamo una revisione dei approcci esistenti nei settori dei sistemi generativi e di sintesi sonore, focalizzando sul posto di nostro lavoro rispetto a questi disciplini e che cosa possiamo aspettare di questa collazione. In seguito, studiamo in maniera piu\u300 precisa i modelli generativi, e come possiamo utilizzare questi recenti avanzati per l\u2019apprendimento di complesse distribuzione di suoni, in un modo che sia flessibile e nel flusso creativo del utente. Quindi proponiamo un processo di inferenza / generazione, il quale rifletta i processi di analisi/sintesi che sono molto usati nel settore del trattamento del segnale audio, usando modelli latenti, che sono basati sull\u2019utilizzazione di un spazio continuato di alto livello, che usiamo per controllare la generazione. Studiamo dapprima i risultati preliminari ottenuti con informazione spettrale estratte da diversi tipi di dati, che valutiamo qualitativamente e quantitativamente. Successiva- mente, studiamo come fare per rendere questi metodi piu\u300 adattati ai segnali audio, fronteggiando tre diversi aspetti. Primo, proponiamo due diversi metodi di regolarizzazione di questo generativo spazio che sono specificamente sviluppati per l\u2019audio : una strategia basata sulla traduzione segnali / simboli, e una basata su vincoli percettivi. Poi, proponiamo diversi metodi per fronteggiare il aspetto temporale dei segnali audio, basati sull\u2019estrazione di rappresentazioni multiscala e sulla predizione, che permettono ai generativi spazi ottenuti di anche modellare l\u2019aspetto dinamico di questi segnali. Per finire, cambiamo il nostro approccio scientifico per un punto di visto piu\u301 ispirato dall\u2019idea di ricerca e creazione. Primo, descriviamo l\u2019architettura e il design della nostra libreria open-source, vsacids, sviluppata per permettere a esperti o non-esperti musicisti di provare questi nuovi metodi di sintesi. Poi, proponiamo una prima utilizzazione del nostro modello con la creazione di una performance in real- time, chiamata \ue6go, basata insieme sulla nostra libreria vsacids e sull\u2019uso di une agente di esplorazione, imparando con rinforzo nel corso della composizione. Finalmente, tramo dal lavoro presentato alcuni conclusioni sui diversi modi di migliorare e rinforzare il metodo di sintesi proposto, nonche\u301 eventuale applicazione artistiche.Among the diverse research fields within computer music, synthesis and generation of audio signals epitomize the cross-disciplinarity of this domain, jointly nourishing both scientific and artistic practices since its creation. Inherent in computer music since its genesis, audio generation has inspired numerous approaches, evolving both with musical practices and scientific/technical advances. Moreover, some syn- thesis processes also naturally handle the reverse process, named analysis, such that synthesis parameters can also be partially or totally extracted from actual sounds, and providing an alternative representation of the analyzed audio signals. On top of that, the recent rise of machine learning algorithms earnestly questioned the field of scientific research, bringing powerful data-centred methods that raised several epistemological questions amongst researchers, in spite of their efficiency. Especially, a family of machine learning methods, called generative models, are focused on the generation of original content using features extracted from an existing dataset. In that case, such methods not only questioned previous approaches in generation, but also the way of integrating this methods into existing creative processes. While these new generative frameworks are progressively introduced in the domain of image generation, the application of such generative techniques in audio synthesis is still marginal. In this work, we aim to propose a new audio analysis-synthesis framework based on these modern generative models, enhanced by recent advances in machine learning. We first review existing approaches, both in sound synthesis and in generative machine learning, and focus on how our work inserts itself in both practices and what can be expected from their collation. Subsequently, we focus a little more on generative models, and how modern advances in the domain can be exploited to allow us learning complex sound distributions, while being sufficiently flexible to be integrated in the creative flow of the user. We then propose an inference / generation process, mirroring analysis/synthesis paradigms that are natural in the audio processing domain, using latent models that are based on a continuous higher-level space, that we use to control the generation. We first provide preliminary results of our method applied on spectral information, extracted from several datasets, and evaluate both qualitatively and quantitatively the obtained results. Subsequently, we study how to make these methods more suitable for learning audio data, tackling successively three different aspects. First, we propose two different latent regularization strategies specifically designed for audio, based on and signal / symbol translation and perceptual constraints. Then, we propose different methods to address the inner temporality of musical signals, based on the extraction of multi-scale representations and on prediction, that allow the obtained generative spaces that also model the dynamics of the signal. As a last chapter, we swap our scientific approach to a more research & creation-oriented point of view: first, we describe the architecture and the design of our open-source library, vsacids, aiming to be used by expert and non-expert music makers as an integrated creation tool. Then, we propose an first musical use of our system by the creation of a real-time performance, called aego, based jointly on our framework vsacids and an explorative agent using reinforcement learning to be trained during the performance. Finally, we draw some conclusions on the different manners to improve and reinforce the proposed generation method, as well as possible further creative applications.A\u300 travers les diffe\u301rents domaines de recherche de la musique computationnelle, l\u2019analysie et la ge\u301ne\u301ration de signaux audio sont l\u2019exemple parfait de la trans-disciplinarite\u301 de ce domaine, nourrissant simultane\u301ment les pratiques scientifiques et artistiques depuis leur cre\u301ation. Inte\u301gre\u301e a\u300 la musique computationnelle depuis sa cre\u301ation, la synthe\u300se sonore a inspire\u301 de nombreuses approches musicales et scientifiques, e\u301voluant de pair avec les pratiques musicales et les avance\u301es technologiques et scientifiques de son temps. De plus, certaines me\u301thodes de synthe\u300se sonore permettent aussi le processus inverse, appele\u301 analyse, de sorte que les parame\u300tres de synthe\u300se d\u2019un certain ge\u301ne\u301rateur peuvent e\u302tre en partie ou entie\u300rement obtenus a\u300 partir de sons donne\u301s, pouvant ainsi e\u302tre conside\u301re\u301s comme une repre\u301sentation alternative des signaux analyse\u301s. Paralle\u300lement, l\u2019inte\u301re\u302t croissant souleve\u301 par les algorithmes d\u2019apprentissage automatique a vivement questionne\u301 le monde scientifique, apportant de puissantes me\u301thodes d\u2019analyse de donne\u301es suscitant de nombreux questionnements e\u301piste\u301mologiques chez les chercheurs, en de\u301pit de leur effectivite\u301 pratique. En particulier, une famille de me\u301thodes d\u2019apprentissage automatique, nomme\u301e mode\u300les ge\u301ne\u301ratifs, s\u2019inte\u301ressent a\u300 la ge\u301ne\u301ration de contenus originaux a\u300 partir de caracte\u301ristiques extraites directement des donne\u301es analyse\u301es. Ces me\u301thodes n\u2019interrogent pas seulement les approches pre\u301ce\u301dentes, mais aussi sur l\u2019inte\u301gration de ces nouvelles me\u301thodes dans les processus cre\u301atifs existants. Pourtant, alors que ces nouveaux processus ge\u301ne\u301ratifs sont progressivement inte\u301gre\u301s dans le domaine la ge\u301ne\u301ration d\u2019image, l\u2019application de ces techniques en synthe\u300se audio reste marginale. Dans cette the\u300se, nous proposons une nouvelle me\u301thode d\u2019analyse-synthe\u300se base\u301s sur ces derniers mode\u300les ge\u301ne\u301ratifs, depuis renforce\u301s par les avance\u301es modernes dans le domaine de l\u2019apprentissage automatique. Dans un premier temps, nous examinerons les approches existantes dans le domaine des syste\u300mes ge\u301ne\u301ratifs, sur comment notre travail peut s\u2019inse\u301rer dans les pratiques de synthe\u300se sonore existantes, et que peut-on espe\u301rer de l\u2019hybridation de ces deux approches. Ensuite, nous nous focaliserons plus pre\u301cise\u301ment sur comment les re\u301centes avance\u301es accomplies dans ce domaine dans ce domaine peuvent e\u302tre exploite\u301es pour l\u2019apprentissage de distributions sonores complexes, tout en e\u301tant suffisamment flexibles pour e\u302tre inte\u301gre\u301es dans le processus cre\u301atif de l\u2019utilisateur. Nous proposons donc un processus d\u2019infe\u301rence / g\ue9n\ue9ration, refle\u301tant les paradigmes d\u2019analyse-synthe\u300se existant dans le domaine de ge\u301ne\u301ration audio, base\u301 sur l\u2019usage de mode\u300les latents continus que l\u2019on peut utiliser pour contro\u302ler la ge\u301ne\u301ration. Pour ce faire, nous e\u301tudierons de\u301ja\u300 les re\u301sultats pre\u301liminaires obtenus par cette me\u301thode sur l\u2019apprentissage de distributions spectrales, prises d\u2019ensembles de donne\u301es diversifie\u301s, en adoptant une approche a\u300 la fois quantitative et qualitative. Ensuite, nous proposerons d\u2019ame\u301liorer ces me\u301thodes de manie\u300re spe\u301cifique a\u300 l\u2019audio sur trois aspects distincts. D\u2019abord, nous proposons deux strate\u301gies de re\u301gularisation diffe\u301rentes pour l\u2019analyse de signaux audio : une base\u301e sur la traduction signal/ symbole, ainsi qu\u2019une autre base\u301e sur des contraintes perceptives. Nous passerons par la suite a\u300 la dimension temporelle de ces signaux audio, proposant de nouvelles me\u301thodes base\u301es sur l\u2019extraction de repre\u301sentations temporelles multi-e\u301chelle et sur une ta\u302che supple\u301mentaire de pre\u301diction, permettant la mode\u301lisation de caracte\u301ristiques dynamiques par les espaces ge\u301ne\u301ratifs obtenus. En dernier lieu, nous passerons d\u2019une approche scientifique a\u300 une approche plus oriente\u301e vers un point de vue recherche & cre\u301ation. Premie\u300rement, nous pre\u301senterons notre librairie open-source, vsacids, visant a\u300 e\u302tre employe\u301e par des cre\u301ateurs experts et non-experts comme un outil inte\u301gre\u301. Ensuite, nous proposons une premie\u300re utilisation musicale de notre syste\u300me par la cre\u301ation d\u2019une performance temps re\u301el, nomme\u301e \ue6go, base\u301e a\u300 la fois sur notre librarie et sur un agent d\u2019exploration appris dynamiquement par renforcement au cours de la performance. Enfin, nous tirons les conclusions du travail accompli jusqu\u2019a\u300 maintenant, concernant les possibles ame\u301liorations et de\u301veloppements de la me\u301thode de synthe\u300se propose\u301e, ainsi que sur de possibles applications cre\u301atives