Validation of an automated assay for measurement of bovine plasma ceruloplasmin

Ceruloplasmin (Cp) plays an important role in copper transport and iron metabolism, as well as Cp is also an indicator for the health status of dairy cows. The present study reports the validation of an automated assay to assess the plasma Cp in dairy cows. Plasma Cp levels were determined in 40 Holstein cows and intra- and inter-assay precision, accuracy, detection limit, and clinical validation of the assay were determined. Intra- and inter-assay coefficients of variation were < 2% and < 7%, respectively. The results were linear when serial sample dilutions were tested (r = 0.999, P < 0.001). The detection limit was lower than what could be measured in plasma from healthy cows. Increased plasma Cp levels were found in cows with inflammatory diseases. The method validated in this study is precise, simple, and fast and can be easily adapted to biochemical automated analysers. Furthermore, the promising results obtained with this protein will contribute to a wider use of Cp determination in bovine practice

Multimedia information technology and the annotation of video

The state of the art in multimedia information technology has not progressed to the point where a single solution is available to meet all reasonable needs of documentalists and users of video archives. In general, we do not have an optimistic view of the usability of new technology in this domain, but digitization and digital power can be expected to cause a small revolution in the area of video archiving. The volume of data leads to two views of the future: on the pessimistic side, overload of data will cause lack of annotation capacity, and on the optimistic side, there will be enough data from which to learn selected concepts that can be deployed to support automatic annotation. At the threshold of this interesting era, we make an attempt to describe the state of the art in technology. We sample the progress in text, sound, and image processing, as well as in machine learning

Sentiment and behaviour annotation in a corpus of dialogue summaries

This paper proposes a scheme for sentiment annotation. We show how the task can be made tractable by focusing on one of the many aspects of sentiment: sentiment as it is recorded in behaviour reports of people and their interactions. Together with a number of measures for supporting the reliable application of the scheme, this allows us to obtain sufficient to good agreement scores (in terms of Krippendorf's alpha) on three key dimensions: polarity, evaluated party and type of clause. Evaluation of the scheme is carried out through the annotation of an existing corpus of dialogue summaries (in English and Portuguese) by nine annotators. Our contribution to the field is twofold: (i) a reliable multi-dimensional annotation scheme for sentiment in behaviour reports; and (ii) an annotated corpus that was used for testing the reliability of the scheme and which is made available to the research community

SemPCA-Summarizer: Exploiting Semantic Principal Component Analysis for Automatic Summary Generation

Text summarization is the task of condensing a document keeping the relevant information. This task integrated in wider information systems can help users to access key information without having to read everything, allowing for a higher efficiency. In this research work, we have developed and evaluated a single-document extractive summarization approach, named SemPCA-Summarizer, which reduces the dimension of a document using Principal Component Analysis technique enriched with semantic information. A concept-sentence matrix is built from the textual input document, and then, PCA is used to identify and rank the relevant concepts, which are used for selecting the most important sentences through different heuristics, thus leading to various types of summaries. The results obtained show that the generated summaries are very competitive, both from a quantitative and a qualitative viewpoint, thus indicating that our proposed approach is appropriate for briefly providing key information, and thus helping to cope with a huge amount of information available in a quicker and efficient manner

Bayesian Synthesis: Combining subjective analyses, with an application to ozone data

Bayesian model averaging enables one to combine the disparate predictions of a number of models in a coherent fashion, leading to superior predictive performance. The improvement in performance arises from averaging models that make different predictions. In this work, we tap into perhaps the biggest driver of different predictions---different analysts---in order to gain the full benefits of model averaging. In a standard implementation of our method, several data analysts work independently on portions of a data set, eliciting separate models which are eventually updated and combined through a specific weighting method. We call this modeling procedure Bayesian Synthesis. The methodology helps to alleviate concerns about the sizable gap between the foundational underpinnings of the Bayesian paradigm and the practice of Bayesian statistics. In experimental work we show that human modeling has predictive performance superior to that of many automatic modeling techniques, including AIC, BIC, Smoothing Splines, CART, Bagged CART, Bayes CART, BMA and LARS, and only slightly inferior to that of BART. We also show that Bayesian Synthesis further improves predictive performance. Additionally, we examine the predictive performance of a simple average across analysts, which we dub Convex Synthesis, and find that it also produces an improvement.Comment: Published in at http://dx.doi.org/10.1214/10-AOAS444 the Annals of Applied Statistics (http://www.imstat.org/aoas/) by the Institute of Mathematical Statistics (http://www.imstat.org

EliXR-TIME: A Temporal Knowledge Representation for Clinical Research Eligibility Criteria.

Effective clinical text processing requires accurate extraction and representation of temporal expressions. Multiple temporal information extraction models were developed but a similar need for extracting temporal expressions in eligibility criteria (e.g., for eligibility determination) remains. We identified the temporal knowledge representation requirements of eligibility criteria by reviewing 100 temporal criteria. We developed EliXR-TIME, a frame-based representation designed to support semantic annotation for temporal expressions in eligibility criteria by reusing applicable classes from well-known clinical temporal knowledge representations. We used EliXR-TIME to analyze a training set of 50 new temporal eligibility criteria. We evaluated EliXR-TIME using an additional random sample of 20 eligibility criteria with temporal expressions that have no overlap with the training data, yielding 92.7% (76 / 82) inter-coder agreement on sentence chunking and 72% (72 / 100) agreement on semantic annotation. We conclude that this knowledge representation can facilitate semantic annotation of the temporal expressions in eligibility criteria