7,195 research outputs found
The intrinsic value of HFO features as a biomarker of epileptic activity
High frequency oscillations (HFOs) are a promising biomarker of epileptic
brain tissue and activity. HFOs additionally serve as a prototypical example of
challenges in the analysis of discrete events in high-temporal resolution,
intracranial EEG data. Two primary challenges are 1) dimensionality reduction,
and 2) assessing feasibility of classification. Dimensionality reduction
assumes that the data lie on a manifold with dimension less than that of the
feature space. However, previous HFO analyses have assumed a linear manifold,
global across time, space (i.e. recording electrode/channel), and individual
patients. Instead, we assess both a) whether linear methods are appropriate and
b) the consistency of the manifold across time, space, and patients. We also
estimate bounds on the Bayes classification error to quantify the distinction
between two classes of HFOs (those occurring during seizures and those
occurring due to other processes). This analysis provides the foundation for
future clinical use of HFO features and buides the analysis for other discrete
events, such as individual action potentials or multi-unit activity.Comment: 5 pages, 5 figure
A roadmap to integrate astrocytes into Systems Neuroscience.
Systems neuroscience is still mainly a neuronal field, despite the plethora of evidence supporting the fact that astrocytes modulate local neural circuits, networks, and complex behaviors. In this article, we sought to identify which types of studies are necessary to establish whether astrocytes, beyond their well-documented homeostatic and metabolic functions, perform computations implementing mathematical algorithms that sub-serve coding and higher-brain functions. First, we reviewed Systems-like studies that include astrocytes in order to identify computational operations that these cells may perform, using Ca2+ transients as their encoding language. The analysis suggests that astrocytes may carry out canonical computations in a time scale of subseconds to seconds in sensory processing, neuromodulation, brain state, memory formation, fear, and complex homeostatic reflexes. Next, we propose a list of actions to gain insight into the outstanding question of which variables are encoded by such computations. The application of statistical analyses based on machine learning, such as dimensionality reduction and decoding in the context of complex behaviors, combined with connectomics of astrocyte-neuronal circuits, is, in our view, fundamental undertakings. We also discuss technical and analytical approaches to study neuronal and astrocytic populations simultaneously, and the inclusion of astrocytes in advanced modeling of neural circuits, as well as in theories currently under exploration such as predictive coding and energy-efficient coding. Clarifying the relationship between astrocytic Ca2+ and brain coding may represent a leap forward toward novel approaches in the study of astrocytes in health and disease
Applications of Information Theory to Analysis of Neural Data
Information theory is a practical and theoretical framework developed for the
study of communication over noisy channels. Its probabilistic basis and
capacity to relate statistical structure to function make it ideally suited for
studying information flow in the nervous system. It has a number of useful
properties: it is a general measure sensitive to any relationship, not only
linear effects; it has meaningful units which in many cases allow direct
comparison between different experiments; and it can be used to study how much
information can be gained by observing neural responses in single trials,
rather than in averages over multiple trials. A variety of information
theoretic quantities are commonly used in neuroscience - (see entry
"Definitions of Information-Theoretic Quantities"). In this entry we review
some applications of information theory in neuroscience to study encoding of
information in both single neurons and neuronal populations.Comment: 8 pages, 2 figure
Oscillations, metastability and phase transitions in brain and models of cognition
Neuroscience is being practiced in many different forms and at many different organizational levels of the Nervous System. Which of these levels and associated conceptual frameworks is most informative for elucidating the association of neural processes with processes of Cognition is an empirical question and subject to pragmatic validation. In this essay, I select the framework of Dynamic System Theory. Several investigators have applied in recent years tools and concepts of this theory to interpretation of observational data, and for designing neuronal models of cognitive functions. I will first trace the essentials of conceptual development and hypotheses separately for discerning observational tests and criteria for functional realism and conceptual plausibility of the alternatives they offer. I will then show that the statistical mechanics of phase transitions in brain activity, and some of its models, provides a new and possibly revealing perspective on brain events in cognition
Explanation of Qualia and Self-Awareness Using Elastic Membrane Concept
In this work we show that our self-awareness and perception may be successfully explained using two dimensional holistic structures with closed topology embedded into our brains - elastic membranes. These membranes are able to preserve their structure during conscious processes. Their elastic oscillations may be associated with our perceptions, where the frequency of the oscillations is responsible for the perception of different colors, sounds and other stimuli, while the amplitude of the oscillations is responsible for the feeling of a distance. According to the model the squeezed regions of a membrane correspond to the brain zones involved into awareness and attention. The model may be useful for prediction, explanation and interpretation of various conscious phenomena
Optimal set of EEG features for emotional state classification and trajectory visualization in Parkinson's disease
In addition to classic motor signs and symptoms, individuals with Parkinson's disease (PD) are characterized by emotional deficits. Ongoing brain activity can be recorded by electroencephalograph (EEG) to discover the links between emotional states and brain activity. This study utilized machine-learning algorithms to categorize emotional states in PD patients compared with healthy controls (HC) using EEG. Twenty non-demented PD patients and 20 healthy age-, gender-, and education level-matched controls viewed happiness, sadness, fear, anger, surprise, and disgust emotional stimuli while fourteen-channel EEG was being recorded. Multimodal stimulus (combination of audio and visual) was used to evoke the emotions. To classify the EEG-based emotional states and visualize the changes of emotional states over time, this paper compares four kinds of EEG features for emotional state classification and proposes an approach to track the trajectory of emotion changes with manifold learning. From the experimental results using our EEG data set, we found that (a) bispectrum feature is superior to other three kinds of features, namely power spectrum, wavelet packet and nonlinear dynamical analysis; (b) higher frequency bands (alpha, beta and gamma) play a more important role in emotion activities than lower frequency bands (delta and theta) in both groups and; (c) the trajectory of emotion changes can be visualized by reducing subject-independent features with manifold learning. This provides a promising way of implementing visualization of patient's emotional state in real time and leads to a practical system for noninvasive assessment of the emotional impairments associated with neurological disorders
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