Hadron models and related New Energy issues

The present book covers a wide-range of issues from alternative hadron models to their likely implications in New Energy research, including alternative interpretation of lowenergy reaction (coldfusion) phenomena. The authors explored some new approaches to describe novel phenomena in particle physics. M Pitkanen introduces his nuclear string hypothesis derived from his Topological Geometrodynamics theory, while E. Goldfain discusses a number of nonlinear dynamics methods, including bifurcation, pattern formation (complex GinzburgLandau equation) to describe elementary particle masses. Fu Yuhua discusses a plausible method for prediction of phenomena related to New Energy development. F. Smarandache discusses his unmatter hypothesis, and A. Yefremov et al. discuss Yang-Mills field from Quaternion Space Geometry. Diego Rapoport discusses theoretical link between Torsion fields and Hadronic Mechanic. A.H. Phillips discusses semiconductor nanodevices, while V. and A. Boju discuss Digital Discrete and Combinatorial methods and their likely implications in New Energy research. Pavel Pintr et al. describe planetary orbit distance from modified Schrödinger equation, and M. Pereira discusses his new Hypergeometrical description of Standard Model of elementary particles. The present volume will be suitable for researchers interested in New Energy issues, in particular their link with alternative hadron models and interpretation

MS FT-2-2 7 Orthogonal polynomials and quadrature: Theory, computation, and applications

Quadrature rules find many applications in science and engineering. Their analysis is a classical area of applied mathematics and continues to attract considerable attention. This seminar brings together speakers with expertise in a large variety of quadrature rules. It is the aim of the seminar to provide an overview of recent developments in the analysis of quadrature rules. The computation of error estimates and novel applications also are described

Generalized averaged Gaussian quadrature and applications

A simple numerical method for constructing the optimal generalized averaged Gaussian quadrature formulas will be presented. These formulas exist in many cases in which real positive GaussKronrod formulas do not exist, and can be used as an adequate alternative in order to estimate the error of a Gaussian rule. We also investigate the conditions under which the optimal averaged Gaussian quadrature formulas and their truncated variants are internal

Modeling the influence of DNA lesion on the regulation of gene expression

Nucleic acids are organic macromolecules that result from the polymerization of nucleotides. These molecules are generally considered as the support of the genetic information. Two families of nucleic acids are currently known: DNA and RNA. From a structural point of view, the most popular form is the double helix of DNA. However, other forms exist and among them are the G-quadruplex. This is a folding of the DNA, or RNA, in an area rich in guanines. These form quadruplex of guanines, which are stacked on top of each other and are stabilized by a central cation. G-quadruplex structures are increasingly studied. This is not surprising since their biological role involves the regulation of genetic mechanisms. They are notably involved in the regulation of the cell cycle, but they also play a role in cancer, certain neurological or viral diseases. The aim of this PhD thesis is to study G-quadruplex using theoretical chemistry tools. The three years of work raise very important points for the research on G-quadruplex. First, the modeling of a theoretical G-quadruplex structure can be achieved by sequence homology and validated by calculations of a theoretical circular dichroism spectrum. Consequently, it is possible to use these tools to propose and use a G-quadruplex structure if it is not yet experimentally solved. Then, the work done shows that G-quadruplex form a very stable folding since they are globally conserved even when 8-oxo-guanine or strand breaks lesions are introduced at the quartets. Then, the paper focuses on the interaction between G-quadruplex and proteins. It highlights the important role of G-quadruplex RNA in the infection of the viral pathogen SARS-CoV-2. This RNA promotes the dimerization of the SUD protein of the virus, which in turn is responsible for the disruption of the immune system. Finally, this thesis provides a structural explanation for the specific interaction between the DARPin 2E4 protein and the G-quadruplex of the c-Myc promoter

Magneto-optical tweezers with super-resolution fluorescence microscopy

This thesis describes the design, construction and application of a novel magneto-optical tweezers with super-resolution fluorescence microscopy for manipulation, force/torque measurement and imaging of single biomolecules. The optical tweezers component offers force or position clamping in three dimensions. The 3D-printed magnetic tweezers is designated for rotation in the vertical plane. The separation of rotation from force transduction results in the capability of precise torque measurement. The filamentous biomolecules to be used in the device will lie in a transverse direction in the imaging plane to allow fluorescence imaging with techniques including Blinking assisted Localisation Microscopy (BaLM) and total internal reflection fluorescence microscopy (TIRF). Also included are features such as acousto-optic deflection and multiplexing of laser traps, interferometry based tracking with quadrant photodiode and piezoelectric actuated nanostage for active feedback. These tweezers have been developed to enable direct observation of molecular topological transformation and protein binding event localisation with mechanical perturbation, which traditional tweezers could not achieve

Aeronautical engineering: A continuing bibliography with indexes (supplement 253)

This bibliography lists 637 reports, articles, and other documents introduced into the NASA scientific and technical information system in May, 1990. Subject coverage includes: design, construction and testing of aircraft and aircraft engines; aircraft components, equipment and systems; ground support systems; and theoretical and applied aspects of aerodynamics and general fluid dynamics